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Adarb1
Gene Detail
Symbol

Name
ID
Adarb1
adenosine deaminase, RNA-specific, B1
MGI:891999
Synonyms
1700057H01Rik, ADAR2, D10Bwg0447e, RED1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:77290726-77418270 bp, - strand
From VEGA annotation of GRCm38

  127545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADARB1
Protein SuperFamily: double-stranded RNA-specific adenosine deaminase
Gene Tree: Adarb1

Human
homologs
ADARB1, adenosine deaminase, RNA-specific, B1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 104
neXtProt AC: NX_P78563

Human Synonyms: ADAR2, DRABA2, DRADA2, RED1

Human Chr (Location): 21q22.3; chr21:45074578-45226563 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(3) Targeted(9)
Genomic Mutations involving Adarb1 (3)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutation of this gene results in progressive seizure susceptibility and death within 20 days of age. Mice homozygous for a conditional allele activated in neurons exhibit motor neuron degeneration, motor function abnormalities, and premature death.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Adarb1 interacts with 476 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adenosine to inosine editing, mRNA modification, ...
Component cytoplasm, nucleolus, ...
Function adenosine deaminase activity, double-stranded RNA adenosine deaminase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (180)    Tissues (122)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
RT-PCR 18
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adarb1 ; ZFIN adarb1a, adarb1b    NEW 
Molecular
reagents
All nucleic(33) Genomic(10) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020501 (Evidence)
Ensembl Gene Model ENSMUSG00000020262 (Evidence)
Entrez Gene 110532 (Evidence)
NIA Mouse Gene Index U031956
EC 3.5.4.37
PDB 2L2K
Consensus CDS Project CCDS35948.1, CCDS35949.1, CCDS35950.1, CCDS35951.1, CCDS35952.1
International Mouse Phenotyping Consortium Status Adarb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020501 VEGA Gene Model | MGI Sequence Detail 127545 C57BL/6J ±  kb
transcript OTTMUST00000048625 VEGA | MGI Sequence Detail 6662 Not Applicable 
polypeptide OTTMUSP00000022336 VEGA | MGI Sequence Detail 711 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(19) UniProt(5)
Polymorphisms
SNPs within 2kb(512 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002466 Adenosine deaminase/editase
InterPro IPR014720 Double-stranded RNA-binding-like domain
Protein Ontology PR:000003746 double-stranded RNA-specific editase 1
References
(Earliest) J:39836 Mittaz L, et al., Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. Genomics. 1997 Apr 15;41(2):210-7
(Latest) J:213258 Akubuiro A, et al., Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice. Genes Brain Behav. 2013 Apr;12(3):311-22
All references(55)
Other
accession IDs
MGD-MRK-34090, MGI:106397, MGI:1923966, MGI:2143815, MGI:2143871, MGI:2143906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory