Serpina1a
Gene Detail

Symbol Name ID

Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A MGI:891971

Synonyms

Aat2, Aat-2, PI1, Spi1-1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:103853589-103863562 bp, - strand From VEGA annotation of GRCm38   9974 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Serpina1a ± 2 cM)

Gene Tree: Serpina1a

Human ortholog

SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 NCBI Gene ID 5265
Human Synonyms: A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
Human Chr14:94843084-94857029 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SERPINA1 (2)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	negative regulation of endopeptidase activity, protein N-linked glycosylation, ...
Component	extracellular region, extracellular space
Function	endopeptidase inhibitor activity, protease binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (8)    Images (26)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	43

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(2) cDNA(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023942 (Evidence)
Ensembl Gene Model	ENSMUSG00000066366 (Evidence)
Entrez Gene	20700 (Evidence)
Consensus CDS Project	CCDS26140.1
International Mouse Knockout Project Status	Serpina1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023942	VEGA Gene Model | MGI Sequence Detail	9974	C57BL/6J
transcript	OTTMUST00000058510	VEGA | MGI Sequence Detail	1360	Not Applicable
polypeptide	OTTMUSP00000028352	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(31) RefSeq(4)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000015927	alpha-1-antitrypsin 1-1

References

(Earliest) J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(28)

Other accession IDs

MGD-MRK-1012, MGD-MRK-1013, MGI:87857