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Serpina1a Gene Detail
Summary
  • Symbol
    Serpina1a
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1A
  • Synonyms
    Aat2, Aat-2, PI1, Spi1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891971
    NCBI Gene: 20700
  • Gene Overview
    MyGene.info: SERPINA1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103853589-103863562 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891971
protein coding gene Chr12:103853295-103863619 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020059
protein coding gene Chr12:105685365-105696125 (-)
A/J MGP_AJ_G0020013
protein coding gene Chr12:101440157-101450757 (-)
AKR/J MGP_AKRJ_G0019994
protein coding gene Chr12:104523834-104542505 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0019805
protein coding gene Chr12:104912029-104923480 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018062
protein coding gene Chr12:98377689-98387691 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019885
protein coding gene Chr12:101034783-101042030 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0019961
protein coding gene Chr12:105331486-105339014 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020477
protein coding gene Chr12:104045060-104050738 (-)
PWK/PhJ MGP_PWKPhJ_G0019110
protein coding gene Chr12:95698425-95700065 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019402
protein coding gene Chr12:104662483-104673095 (-)



Homology
more
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    SERPINA1, serpin family A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A1A, A1AT, AAT, alpha1AT, nNIF, PI, PI1, PRO2275
  • Links
    NCBI Gene ID: 5265
    neXtProt AC: NX_P01009
    UniProt: P01009

  • Chr Location
    14q32.13; chr14:94376747-94390692 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human SERPINA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066366 Ensembl Gene Model | MGI Sequence Detail 9974 C57BL/6J ±  kb
transcript ENSMUST00000072876 Ensembl | MGI Sequence Detail 1581 Not Applicable  
polypeptide ENSMUSP00000072652 Ensembl | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1012, MGD-MRK-1013, MGI:87857
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
  • Latest
    J:248950 Elshikha AS, et al., Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus. PLoS One. 2016;11(5):e0156583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory