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Serpina1a
Gene Detail
Symbol

Name
ID
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
MGI:891971
Synonyms
Aat2, Aat-2, PI1, Spi1-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:103853589-103863562 bp, - strand
From VEGA annotation of GRCm38

  9974 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20103  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 chicken; 3 western clawed frog; 2 zebrafish

HCOP human homology predictions: SERPINA1
Protein SuperFamily: serpin
Gene Tree: Serpina1a

Human
homologs
SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5265
neXtProt AC: NX_P01009

Human Synonyms: A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275

Human Chr (Location): 14q32.1; chr14:94376747-94390692 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SERPINA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele die prior to E8.5.
 
Interactions
Serpina1a interacts with 15 markers (Mir22, Mir218-2, Mir466, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (43)    Tissues (8)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase serpina1    NEW 
Molecular
reagents
All nucleic(6) Genomic(2) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023942 (Evidence)
Ensembl Gene Model ENSMUSG00000066366 (Evidence)
Entrez Gene 20700 (Evidence)
Consensus CDS Project CCDS26140.1, CCDS79152.1
International Mouse Phenotyping Consortium Status Serpina1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023942 VEGA Gene Model | MGI Sequence Detail 9974 C57BL/6J ±  kb
transcript OTTMUST00000058509 VEGA | MGI Sequence Detail 1581 Not Applicable 
polypeptide OTTMUSP00000028351 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)    SNPs within 2kb including multiple locations(333)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015927 alpha-1-antitrypsin 1-1
References
(Earliest) J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
(Latest) J:208746 Wang D, et al., Deletion of Serpina1a, a murine alpha1-antitrypsin ortholog, results in embryonic lethality. Exp Lung Res. 2011 Jun;37(5):291-300
All references(30)
Other
accession IDs
MGD-MRK-1012, MGD-MRK-1013, MGI:87857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory