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Serpina1b
Gene Detail
 Symbol
Name
ID
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
MGI:891970
Synonyms D12Ucla2, PI2, Spi1-2
Feature Type protein coding gene
Genetic Map
Chromosome 12
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:103728156-103740515 bp, - strand
From VEGA annotation of GRCm38

  12360 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20103  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 chicken; 3 western clawed frog; 2 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpina1b

Human
homologs
Human Homolog SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
NCBI Gene ID 5265
neXtProt AC  NX_P01009
Human Synonyms  A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
Human Chr (Location)  14q32.1; chr14:94376747-94390692 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SERPINA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Targeted disruption of this gene leads to significantly fewer than expected heterozygous and homozygous offspring from heterozygous matings. Homozygotes are healthy with no obvious changes in major organs while heterozygotes show a 30% decrease in serum anti-elastase and anti-chymotrypsin activity.
 
Interactions
Serpina1b interacts with 13 markers (Mir22, Mir218-2, Mir340, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process acute-phase response, in utero embryonic development, ...
Component endoplasmic reticulum, extracellular region, ...
Function endopeptidase inhibitor activity, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (48)    Tissues (8)    Images (23)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 48
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(2) cDNA(8) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035410 (Evidence)
Ensembl Gene ModelENSMUSG00000071178 (Evidence)
Entrez Gene20701 (Evidence)
Consensus CDS ProjectCCDS26138.1
International Mouse Knockout Project StatusSerpina1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035410 VEGA Gene Model | MGI Sequence Detail 12360 C57BL/6J ±  kb
transcript OTTMUST00000090560 VEGA | MGI Sequence Detail 1394 Not Applicable 
polypeptide OTTMUSP00000049718 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(248 from dbSNP Build 137)    SNPs within 2kb including multiple locations(312)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015928 alpha-1-antitrypsin 1-2
References (Earliest) J:10300 Sifers RN, et al., Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin. Genomics. 1990 Jan;6(1):100-4
(Latest) J:178622 McNab GL, et al., A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency. Mamm Genome. 2011 Nov 11;
All references(31)
Other
accession IDs
MGD-MRK-3362, MGI:89582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory