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Serpina1e Gene Detail
Summary
  • Symbol
    Serpina1e
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1E
  • Synonyms
    PI5, Spi1-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:891967
    NCBI Gene: 20704
  • Gene Overview
    MyGene.info: SERPINA1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:103946931-103956897 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.98 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891967
 protein coding gene Chr12:103946931-103958975 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020061
 protein coding gene Chr12:105685365-105706623 (-)
A/J MGP_AJ_G0020015
 protein coding gene Chr12:101440157-101459302 (-)
AKR/J MGP_AKRJ_G0019993
 protein coding gene Chr12:104455916-104484402 (-)
BALB/cJ MGP_BALBcJ_G0020001
 protein coding gene Chr12:101792615-101802960 (-)
C3H/HeJ MGP_C3HHeJ_G0019804
 protein coding gene Chr12:104850598-104874948 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020449
 protein coding gene Chr12:109000791-109025875 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018064
 protein coding gene Chr12:98377689-98389871 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019887
 protein coding gene Chr12:101034783-101048068 (-)
FVB/NJ MGP_FVBNJ_G0019875
 protein coding gene Chr12:99923316-99941509 (-)
LP/J MGP_LPJ_G0019964
 protein coding gene Chr12:105424884-105437526 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018910
 protein coding gene Chr12:98179738-98200646 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    SERPINA1, serpin family A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A1A, A1AT, AAT, alpha1AT, nNIF, PI, PI1, PRO2275
  • Links
    NCBI Gene ID: 5265
    neXtProt AC: NX_P01009
    UniProt: P01009

  • Chr Location
    14q32.13; chr14:94376747-94390692 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human SERPINA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    13
  • cDNA Data
    298
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20704 NCBI Gene Model | MGI Sequence Detail 9967 C57BL/6J ±  kb
transcript NM_009247 RefSeq | MGI Sequence Detail 1374 Not Specified  
polypeptide Q00898 UniProt | EBI | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 299
    cDNA 299

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/20/2020
MGI 6.16 		The Jackson Laboratory