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Serpina1e
Gene Detail
Symbol

Name
ID
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
MGI:891967
Synonyms
PI5, Spi1-5
Feature Type
protein coding gene
Genetic Map
Chromosome 12
52.98 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:103946931-103958975 bp, - strand
From VEGA annotation of GRCm38

  12045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20103  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 chicken; 3 western clawed frog; 2 zebrafish

HCOP human homology predictions: SERPINA1
Protein SuperFamily: serpin
Gene Tree: Serpina1e

Human
homologs
SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5265
neXtProt AC: NX_P01009

Human Synonyms: A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275

Human Chr (Location): 14q32.1; chr14:94376747-94390692 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SERPINA1

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Serpina1e interacts with 12 markers (Mir22, Mir218-2, Mir466, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (13)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(297)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(298) cDNA(298)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000027635 (Evidence)
Ensembl Gene Model ENSMUSG00000072849 (Evidence)
Entrez Gene 20704 (Evidence)
UniGene 312593
Consensus CDS Project CCDS26142.1
International Mouse Phenotyping Consortium Status Serpina1e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027635 VEGA Gene Model | MGI Sequence Detail 12045 C57BL/6J ±  kb
transcript OTTMUST00000068380 VEGA | MGI Sequence Detail 1575 Not Applicable 
polypeptide OTTMUSP00000034559 VEGA | MGI Sequence Detail 413 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)    SNPs within 2kb including multiple locations(257)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015931 alpha-1-antitrypsin 1-5
References
(Earliest) J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory