Serpina1e MGI Mouse Gene Detail - MGI:891967 - serine (or cysteine) peptidase inhibitor, clade A, member 1E

Serpina1e Gene Detail

Human Ortholog

SERPINA1, serpin family A member 1
Orthology source: HomoloGene, HGNC
Synonyms

A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
Links

HGNC:8941

NCBI Gene ID: 5265

neXtProt AC: NX_P01009

UniProt: P01009
Chr Location

14q32.13; chr14:94376747-94390692 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20103
1 human;5 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;4 chicken;2 zebrafish;3 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SERPINA1
Protein SuperFamily

serpin
Gene Tree

Serpina1e

				Human Disease	Mouse Models
				alpha 1-antitrypsin deficiency IDs alpha 1-antitrypsin deficiency DOID:13372 ICD10CM:E88.01 ICD9CM:273.4 MESH:D019896 NCI:C84397 OMIM:613490 UMLS_CUI:C0221757

Click on a disease name to see all genes associated with that disease.

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

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			Length	Strain/Species	Flank
genomic	OTTMUSG00000027635	VEGA Gene Model \| MGI Sequence Detail	12045	C57BL/6J	± kb
transcript	OTTMUST00000068380	VEGA \| MGI Sequence Detail	1575	Not Applicable
polypeptide	OTTMUSP00000034559	VEGA \| MGI Sequence Detail	413	Not Applicable

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Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 2
Earliest

J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/11/2017 MGI 6.10