Serpina1e
Gene Detail

Symbol Name ID

Serpina1e serine (or cysteine) peptidase inhibitor, clade A, member 1E MGI:891967

Synonyms

PI5, Spi1-5

Feature Type

protein coding gene

Genetic Map

Chromosome 12

52.98 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:103946931-103958975 bp, - strand From VEGA annotation of GRCm38   12045 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20103  Vertebrate Homology Class
1 human; 5 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 chicken; 2 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpina1e

Human homologs

Human Homolog		SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
NCBI Gene ID		5265
neXtProt AC		NX_P01009
Human Synonyms		A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
Human Chr (Location)		14q32.1; chr14:94376747-94390692 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human SERPINA1

Mutations, alleles, and phenotypes

Incidental mutations (data from Mutagenetix , APF )

Interactions

Serpina1e interacts with 12 markers (Mir22, Mir218-2, Mir466, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	endoplasmic reticulum, extracellular region, ...
Function	endopeptidase inhibitor activity, glycoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (98)    Tissues (13)    Images (47)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	98

cDNA source data(297)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(298) cDNA(298)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000027635 (Evidence)
Ensembl Gene Model	ENSMUSG00000072849 (Evidence)
Entrez Gene	20704 (Evidence)
UniGene	312593
Consensus CDS Project	CCDS26142.1
International Mouse Knockout Project Status	Serpina1e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027635	VEGA Gene Model | MGI Sequence Detail	12045	C57BL/6J
transcript	OTTMUST00000068380	VEGA | MGI Sequence Detail	1575	Not Applicable
polypeptide	OTTMUSP00000034559	VEGA | MGI Sequence Detail	413	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(211 from dbSNP Build 137)    SNPs within 2kb including multiple locations(257)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000015931	alpha-1-antitrypsin 1-5

References

(Earliest) J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)