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Serpina1e Gene Detail
Summary
  • Symbol
    Serpina1e
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1E
  • Synonyms
    PI5, Spi1-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:891967
    NCBI Gene: 20704
  • Gene Overview
    MyGene.info: SERPINA1
Location & Maps
more
  • Sequence Map
    Chr12:103946931-103958975 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12045 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 52.98 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SERPINA1, serpin family A member 1
  • Vertebrate Orthologs
    20
  • Human Ortholog
    SERPINA1, serpin family A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A1A, A1AT, AAT, alpha1AT, PI, PI1, PRO2275
  • Links
    NCBI Gene ID: 5265
    neXtProt AC: NX_P01009

  • Chr Location
    14q32.1; chr14:94376747-94390692 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    2 with human SERPINA1 associations

Human Disease Mouse Models
       Alpha-1-Antitrypsin Deficiency; A1ATD   OMIM: 613490
Pulmonary Disease, Chronic Obstructive; COPD   OMIM: 606963
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Serpina1e
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    98
  • Tissues
    13
  • cDNA Data
    297
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027635 VEGA Gene Model | MGI Sequence Detail 12045 C57BL/6J ±  kb
transcript OTTMUST00000068380 VEGA | MGI Sequence Detail 1575 Not Applicable  
polypeptide OTTMUSP00000034559 VEGA | MGI Sequence Detail 413 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 298
    cDNA 298

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:23546 Borriello F, et al., Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9417-21
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory