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Cyp1a2
Gene Detail
 Symbol
Name
ID
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
MGI:88589
STS D9Mit101, D9Mit21, D9Nds5
Synonyms aromatic compound inducible, CP12, P450-3
Feature Type protein coding gene
Genetic Map
Chromosome 9
31.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr9:57676937-57683655 bp, - strand
From NCBI annotation of GRCm38

  6719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp1a2

Human
homologs
Human Homolog CYP1A2, cytochrome P450, family 1, subfamily A, polypeptide 2
NCBI Gene ID 1544
neXtProt AC  NX_P05177
Human Synonyms  CP12, P3-450, P450(PA)
Human Chr (Location)  15q24.1; chr15:74748843-74756600 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP1A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
 
Interactions
Cyp1a2 interacts with 30 markers (Mir26a-2, Mir31, Mir127, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process alkaloid metabolic process, cellular aromatic compound metabolic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function aromatase activity, caffeine oxidase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (106)   
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 24
cDNA source data(109)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(117) Genomic(4) cDNA(110) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032310 (Evidence)
Entrez Gene13077 (Evidence)
UniGene15537
DFCITC1577263
DoTSDT.490202
NIA Mouse Gene IndexU030927
EC1.14.14.1
Consensus CDS ProjectCCDS23229.1
International Mouse Knockout Project StatusCyp1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13077 NCBI Gene Model | MGI Sequence Detail 6719 C57BL/6J ±  kb
transcript NM_009993 RefSeq | MGI Sequence Detail 1892 Not Specified 
polypeptide P00186 UniProt | EBI | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(10) : PCR(6) RFLP(4) SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
InterPro IPR008066 Cytochrome P450, E-class, group I, CYP1
Protein Ontology PR:000006102 cytochrome P450 1A2
Graphical View of Protein Domain Structure
References (Earliest) J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
(Latest) J:209865 van Voorhis M, et al., Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS One. 2013;8(12):e82545
All references(129)
Other
accession IDs
MGD-MRK-13112, MGD-MRK-2303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory