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Cyp1a2 Gene Detail
Summary
  • Symbol
    Cyp1a2
  • Name
    cytochrome P450, family 1, subfamily a, polypeptide 2
  • Synonyms
    aromatic compound inducible, CP12, P450-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88589
    NCBI Gene: 13077
  • Gene Overview
    MyGene.info: CYP1A2
Location & Maps
more
  • Sequence Map
    Chr9:57676937-57683655 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.30 cM
  • Mapping Data
    24 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    CYP1A2, cytochrome P450 family 1 subfamily A member 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CYP1A2, cytochrome P450 family 1 subfamily A member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CP12, P3-450, P450(PA)
  • Links
    NCBI Gene ID: 1544
    neXtProt AC: NX_P05177

  • Chr Location
    15q24.1; chr15:74748843-74756600 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CYP1A2 associations

Human Disease Mouse Models
       Cytochrome P450, Subfamily I, Polypeptide 2; CYP1A2   OMIM: 124060
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cyp1a2
  • Incidental Mutations
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13077 NCBI Gene Model | MGI Sequence Detail 6719 C57BL/6J ±  kb
transcript NM_009993 RefSeq | MGI Sequence Detail 1892 Not Specified  
polypeptide P00186 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    119 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 117
    Genomic 4
    cDNA 110
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13112, MGD-MRK-2303
References
more
  • Summaries
    All 128
    Developmental Gene Expression 5
    Gene Ontology 17
    Phenotypes 43
  • Earliest
    J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
  • Latest
    J:227867 Wang S, et al., N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer. Toxicol Sci. 2015 Apr;144(2):393-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory