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Cyp19a1
Gene Detail
Symbol

Name
ID
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
MGI:88587
Synonyms
Ar, ArKO, aromatase, Cyp19, Int5, Int-5, p450arom
Feature Type
protein coding gene
Genetic Map
Chromosome 9
29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:54165937-54193442 bp, - strand
From Ensembl annotation of GRCm38

  27506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CYP19A1
Protein SuperFamily: cytochrome P450 CYP19
Gene Tree: Cyp19a1

Human
homologs
CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1588
neXtProt AC: NX_P11511

Human Synonyms: ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM

Human Chr (Location): 15q21.1; chr15:51208057-51338598 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CYP19A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(7) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
 
Human Diseases Modeled in Mice Using Cyp19a1 (3)    Mutations Annotated to Human Diseases (3)    Phenotype Images(3)
Interactions
Cyp19a1 interacts with 102 markers (Mir10a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process androgen metabolic process, C21-steroid hormone metabolic process, ...
Component axon terminus, cytoplasm, ...
Function aromatase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (239)    Tissues (182)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 132
In situ reporter (knock in) 6
RT-PCR 99
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cyp19a1 ; ZFIN cyp19a1a, cyp19a1b    NEW 
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(14) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032274 (Evidence)
Entrez Gene 13075 (Evidence)
DFCI TC1590527
DoTS DT.91333446
NIA Mouse Gene Index U030880
EC 1.14.14.14
Consensus CDS Project CCDS23187.1
International Mouse Phenotyping Consortium Status Cyp19a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 27506 C57BL/6J ±  kb
transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable 
polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(16) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006100 cytochrome P450 19A1
References
(Earliest) J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(179)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory