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Cyp19a1
Gene Detail
Symbol

Name
ID
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
MGI:88587
Synonyms
Ar, ArKO, aromatase, Cyp19, Int5, Int-5, p450arom
Feature Type
protein coding gene
Genetic Map
Chromosome 9
29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:54165937-54193442 bp, - strand
From Ensembl annotation of GRCm38

  27506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: cytochrome P450 CYP19
Gene Tree: Cyp19a1

Human
homologs
Human Homolog CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1
NCBI Gene ID 1588
neXtProt AC  NX_P11511
Human Synonyms  ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
Human Chr (Location)  15q21.1; chr15:51208057-51338598 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYP19A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
 
Human Diseases Modeled Using Mouse Cyp19a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Cyp19a1 interacts with 103 markers (Mir10a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process androgen metabolic process, C21-steroid hormone metabolic process, ...
Component axon terminus, cytoplasm, ...
Function aromatase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (232)    Tissues (181)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 131
RT-PCR 99
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(13) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032274 (Evidence)
Entrez Gene13075 (Evidence)
DFCITC1590527
DoTSDT.91333446
NIA Mouse Gene IndexU030880
EC1.14.14.14
Consensus CDS ProjectCCDS23187.1
International Mouse Knockout Project StatusCyp19a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 27506 C57BL/6J ±  kb
transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable 
polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(12) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006100 cytochrome P450 19A1
References
(Earliest) J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
(Latest) J:213539 Toda K, et al., Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses. Transgenic Res. 2014 Apr;23(2):293-302
All references(179)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory