Cyp19a1
Gene Detail

Symbol Name ID

Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 MGI:88587

Synonyms

Ar, ArKO, aromatase, Cyp19, Int5, Int-5, p450arom

Feature Type

protein coding gene

Genetic Map

Chromosome 9

29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr9:54165937-54193442 bp, - strand From NCBI annotation of GRCm38   27506 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; horse; rabbit, European; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Cyp19a1 ± 2 cM)

Protein SuperFamily: cytochrome P450 CYP19
Gene Tree: Cyp19a1

Human ortholog

CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 NCBI Gene ID 1588
Human Synonyms: ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
Human Chr15:51500254-51630795 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CYP19A1 (2)

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.

 
Human Diseases Modeled Using Mouse Cyp19a1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	androgen metabolic process, C21-steroid hormone metabolic process, ...
Component	axon terminus, cytoplasm, ...
Function	aromatase activity, electron carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (231)    Tissues (177)    Images (14)
Theiler Stages: 1, 2, 3, 4, 5, 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	123
RT-PCR	105

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(6) cDNA(12) Primer pair(8) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032274 (Evidence)
Entrez Gene	13075 (Evidence)
DFCI	TC1590527
DoTS	DT.91333446
NIA Mouse Gene Index	U030880
EC	1.14.14.1
Consensus CDS Project	CCDS23187.1
International Mouse Knockout Project Status	Cyp19a1

Sequences

Length	Strain/Species
genomic	13075	NCBI Gene Model | MGI Sequence Detail	27506	C57BL/6J
transcript	NM_007810	RefSeq | MGI Sequence Detail	2373	C57BL/6
polypeptide	P28649	UniProt | EBI | MGI Sequence Detail	503	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
Protein Ontology	PR:000006100	cytochrome P450 19A1

Graphical View of Protein Domain Structure

References

(Earliest) J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
(Latest) J:189534 Toda K, et al., 17beta-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice. Mol Cell Endocrinol. 2012 Oct 15;362(1-2):176-82
All references(173)

Other accession IDs

MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301