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Cyp19a1
Gene Detail
 Symbol
Name
ID
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
MGI:88587
Synonyms Ar, ArKO, aromatase, Cyp19, Int5, Int-5, p450arom
Feature Type protein coding gene
Genetic Map
Chromosome 9
29.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:54165937-54193442 bp, - strand
From NCBI annotation of GRCm38

  27506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cytochrome P450 CYP19
Gene Tree: Cyp19a1

Human
homologs
Human Homolog CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1
NCBI Gene ID 1588
neXtProt AC  NX_P11511
Human Synonyms  ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
Human Chr (Location)  15q21.1; chr15:51208057-51338598 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYP19A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
 
Human Diseases Modeled Using Mouse Cyp19a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Cyp19a1 interacts with 103 markers (Mir10a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process androgen metabolic process, C21-steroid hormone metabolic process, ...
Component axon terminus, cytoplasm, ...
Function aromatase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (233)    Tissues (179)    Images (23)
Theiler Stages: 1, 2, 3, 4, 5, 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 131
RT-PCR 99
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(13) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032274 (Evidence)
Entrez Gene13075 (Evidence)
DFCITC1590527
DoTSDT.91333446
NIA Mouse Gene IndexU030880
EC1.14.14.14
Consensus CDS ProjectCCDS23187.1
International Mouse Knockout Project StatusCyp19a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13075 NCBI Gene Model | MGI Sequence Detail 27506 C57BL/6J ±  kb
transcript NM_007810 RefSeq | MGI Sequence Detail 2373 C57BL/6 
polypeptide P28649 UniProt | EBI | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006100 cytochrome P450 19A1
Graphical View of Protein Domain Structure
References (Earliest) J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
(Latest) J:205150 Fester L, et al., Estradiol responsiveness of synaptopodin in hippocampal neurons is mediated by estrogen receptor beta. J Steroid Biochem Mol Biol. 2013 Nov;138:455-61
All references(176)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory