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Cyp19a1 Gene Detail
Summary
  • Symbol
    Cyp19a1
  • Name
    cytochrome P450, family 19, subfamily a, polypeptide 1
  • Synonyms
    Ar, ArKO, aromatase, Cyp19, Int5, Int-5, p450arom
  • Feature Type
    protein coding gene
  • IDs
    MGI:88587
    NCBI Gene: 13075
  • Gene Overview
    MyGene.info: CYP19A1
Location & Maps
more
  • Sequence Map
    Chr9:54165937-54193442 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27506 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.49 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
  • Links
    NCBI Gene ID: 1588
    neXtProt AC: NX_P11511

  • Chr Location
    15q21.2; chr15:51208057-51338598 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Cyp19a1 mouse models; 2 with human CYP19A1 associations

Human Disease Mouse Models
       Aromatase Excess Syndrome; AEXS   OMIM: 139300 View 1 model
       Obsessive-Compulsive Disorder; OCD   OMIM: 164230 View 1 model
Sjogren Syndrome   OMIM: 270150 View 2 models
       Aromatase Deficiency   OMIM: 613546
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    145 phenotypes from 6 alleles in 9 genetic backgrounds
    22 phenotypes from multigenic genotypes
    3 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 27506 C57BL/6J ±  kb
transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable  
polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    258 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 30
    Genomic 6
    cDNA 14
    Primer pair 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301
References
more
  • Summaries
    All 184
    Developmental Gene Expression 26
    Diseases 4
    Gene Ontology 9
    Phenotypes 119
  • Earliest
    J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
  • Latest
    J:234188 Brus M, et al., Estradiol-induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor. J Neurochem. 2016 Aug;138(3):457-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory