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Cyp17a1
Gene Detail
 Symbol
Name
ID
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
MGI:88586
Synonyms Cyp17, p450c17, steroid 17-alpha hydroxylase
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr19:46667165-46672974 bp, - strand
From VEGA annotation of GRCm38

  5810 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp17a1

Human
homologs
Human Homolog CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1
NCBI Gene ID 1586
neXtProt AC  NX_P05093
Human Synonyms  CPT7, CYP17, P450C17, S17AH
Human Chr (Location)  10q24.3; chr10:102830531-102837533 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP17A1
Alleles
and
phenotypes
All alleles(4) : Targeted(3) Gene trapped(1)
 
Homozygous null embryos display early embryonic lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process glucocorticoid biosynthetic process, hormone biosynthetic process, ...
Component axon, cell projection, ...
Function 17-alpha-hydroxyprogesterone aldolase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (319)    Tissues (228)    Images (34)
Theiler Stages: 4, 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 210
RT-PCR 107
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(50) Genomic(13) cDNA(29) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023316 (Evidence)
Ensembl Gene ModelENSMUSG00000003555 (Evidence)
Entrez Gene13074 (Evidence)
UniGene1262
DFCITC1581537
DoTSDT.488453
NIA Mouse Gene IndexU039115
EC1.14.99.9, 4.1.2.30
Consensus CDS ProjectCCDS29882.1
International Mouse Knockout Project StatusCyp17a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023316 VEGA Gene Model | MGI Sequence Detail 5810 C57BL/6J ±  kb
transcript OTTMUST00000056481 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000027151 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006099 cytochrome P450 17A1
References (Earliest) J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
(Latest) J:194288 Manosalva I, et al., Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Dev Biol. 2013 Mar 15;375(2):140-51
All references(103)
Other
accession IDs
MGD-MRK-2300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory