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Cyp17a1 Gene Detail
Summary
  • Symbol
    Cyp17a1
  • Name
    cytochrome P450, family 17, subfamily a, polypeptide 1
  • Synonyms
    Cyp17, p450c17, steroid 17-alpha hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88586
    NCBI Gene: 13074
  • Gene Overview
    MyGene.info: CYP17A1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46667165-46672974 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.97 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88586
protein coding gene Chr19:46667165-46673000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025214
protein coding gene Chr19:46416225-46422034 (-)
A/J MGP_AJ_G0025190
protein coding gene Chr19:44090678-44096487 (-)
AKR/J MGP_AKRJ_G0025159
protein coding gene Chr19:45526387-45532196 (-)
BALB/cJ MGP_BALBcJ_G0025185
protein coding gene Chr19:44146838-44152647 (-)
C3H/HeJ MGP_C3HHeJ_G0024945
protein coding gene Chr19:45707319-45713134 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025628
protein coding gene Chr19:47529063-47534872 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023042
protein coding gene Chr19:43334131-43339480 (-)
CAST/EiJ MGP_CASTEiJ_G0024410
protein coding gene Chr19:45517879-45523746 (-)
CBA/J MGP_CBAJ_G0024925
protein coding gene Chr19:49917973-49923804 (-)
DBA/2J MGP_DBA2J_G0025057
protein coding gene Chr19:43911586-43917395 (-)
FVB/NJ MGP_FVBNJ_G0025018
protein coding gene Chr19:43697005-43702836 (-)
LP/J MGP_LPJ_G0025143
protein coding gene Chr19:46298424-46304233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025049
protein coding gene Chr19:49258197-49264006 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025686
protein coding gene Chr19:45643784-45649615 (-)
PWK/PhJ MGP_PWKPhJ_G0024159
protein coding gene Chr19:43866602-43872516 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023963
protein coding gene Chr19:44292256-44298136 (-)
WSB/EiJ MGP_WSBEiJ_G0024480
protein coding gene Chr19:45790130-45795939 (-)



Homology
more
  • Human Ortholog
    CYP17A1, cytochrome P450 family 17 subfamily A member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CYP17A1, cytochrome P450 family 17 subfamily A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPT7, CYP17, P450C17, S17AH
  • Links
    NCBI Gene ID: 1586
    neXtProt AC: NX_P05093
    UniProt: P05093

  • Chr Location
    10q24.32; chr10:102830531-102837533 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CYP17A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003555 Ensembl Gene Model | MGI Sequence Detail 5810 C57BL/6J ±  kb
    transcript ENSMUST00000026012 Ensembl | MGI Sequence Detail 1815 Not Applicable  
    polypeptide ENSMUSP00000026012 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 13
      cDNA 31
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2300
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 69
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
    • Latest
      J:256730 Shawki HH, et al., MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. PLoS One. 2018;13(1):e0190800

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory