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Cyp17a1
Gene Detail
Symbol

Name
ID
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
MGI:88586
Synonyms
Cyp17, p450c17, steroid 17-alpha hydroxylase
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr19:46667165-46672974 bp, - strand
From VEGA annotation of GRCm38

  5810 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CYP17A1
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp17a1

Human
homologs
CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1586
neXtProt AC: NX_P05093

Human Synonyms: CPT7, CYP17, P450C17, S17AH

Human Chr (Location): 10q24.3; chr10:102830531-102837533 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP17A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos display early embryonic lethality.
 
Interactions
Cyp17a1 interacts with 43 markers (Mir127, Mir133b, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process glucocorticoid biosynthetic process, hormone biosynthetic process, ...
Component axon, cell projection, ...
Function 17-alpha-hydroxyprogesterone aldolase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (329)    Tissues (233)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 210
RT-PCR 117
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyp17a1 ; ZFIN cyp17a1    NEW 
Molecular
reagents
All nucleic(53) Genomic(13) cDNA(30) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023316 (Evidence)
Ensembl Gene Model ENSMUSG00000003555 (Evidence)
Entrez Gene 13074 (Evidence)
UniGene 1262
DFCI TC1581537
DoTS DT.488453
NIA Mouse Gene Index U039115
EC 1.14.99.9, 4.1.2.30
Consensus CDS Project CCDS29882.1
International Mouse Phenotyping Consortium Status Cyp17a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023316 VEGA Gene Model | MGI Sequence Detail 5810 C57BL/6J ±  kb
transcript OTTMUST00000056481 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000027151 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006099 cytochrome P450 17A1
References
(Earliest) J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
(Latest) J:220734 Zhang L, et al., Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4003-8
All references(104)
Other
accession IDs
MGD-MRK-2300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory