Cyp17a1
Gene Detail

Symbol Name ID

Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 MGI:88586

Synonyms

Cyp17, p450c17, steroid 17-alpha hydroxylase

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr19:46667165-46672974 bp, - strand From VEGA annotation of GRCm38   5810 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Cyp17a1 ± 2 cM)

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp17a1

Human ortholog

CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 NCBI Gene ID 1586
Human Synonyms: CPT7, CYP17, P450C17, S17AH
Human Chr10:104590288-104597290 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CYP17A1 (1)

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null embryos display early embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	glucocorticoid biosynthetic process, oxidation-reduction process, ...
Component	axon, cell projection, ...
Function	electron carrier activity, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (46 records)
Data Summary: Results (308)    Tissues (225)    Images (25)
Theiler Stages: 4, 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	199
RT-PCR	107

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(13) cDNA(28) Primer pair(7) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023316 (Evidence)
Ensembl Gene Model	ENSMUSG00000003555 (Evidence)
Entrez Gene	13074 (Evidence)
UniGene	1262
DFCI	TC1581537
DoTS	DT.488453
NIA Mouse Gene Index	U039115
EC	1.14.99.9
Consensus CDS Project	CCDS29882.1
International Mouse Knockout Project Status	Cyp17a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023316	VEGA Gene Model | MGI Sequence Detail	5810	C57BL/6J
transcript	OTTMUST00000056481	VEGA | MGI Sequence Detail	1815	Not Applicable
polypeptide	OTTMUSP00000027151	VEGA | MGI Sequence Detail	507	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002401	Cytochrome P450, E-class, group I
Protein Ontology	PR:000006099	cytochrome P450 17A1

References

(Earliest) J:26017 Perkins LM, et al., Quantification of P450scc, P450(17) alpha, and iron sulfur protein reductase in Leydig cells and adrenals of inbred strains of mice. Endocrinology. 1988 Dec;123(6):2675-82
(Latest) J:192626 Miyado M, et al., Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology. 2012 Dec;153(12):6033-40
All references(99)

Other accession IDs

MGD-MRK-2300