Cyp17a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
MGI:88586

29 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp17a1^{tm1b(EUCOMM)Wtsi}/Cyp17a1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cyp17a1^{tm1b(EUCOMM)Wtsi}/Nju	abnormal auditory brainstem response	J:211773
	abnormal bone structure	J:211773
	abnormal male genitalia morphology	J:211773
	abnormal vocalization	J:211773
	absent external male genitalia	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased circulating phosphate level	J:211773
	decreased grip strength	J:211773
	decreased heart weight	J:211773
	decreased lean body mass	J:211773
	decreased locomotor activity	J:211773
	improved glucose tolerance	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating creatinine level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased fasting circulating glucose level	J:211773
	increased total body fat amount	J:211773
Cyp17a1^tm1Mell/Cyp17a1^tm1Mell involves: 129X1/SvJ * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:91081
Cyp17a1^tm1Vpap/Cyp17a1⁺ chimera involves: 129X1/SvJ * C57BL/6	abnormal sexual interaction	J:100434
	abnormal sperm flagellum morphology	J:100434
	abnormal testosterone level	J:100434
	asthenozoospermia	J:100434
	decreased circulating testosterone level	J:100434
	early reproductive senescence	J:100434
	reduced male fertility	J:100434
	transmission ratio distortion	J:100434

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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