Symbol
Name
ID

Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
MGI:88586

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Hyperkalemia

Hypokalemia

Hyponatremia

Elevated circulating hepatic transaminase concentration

Hypoglycemia

Diabetes mellitus

Hypokalemic alkalosis

Fever

Recurrent fever

Renal salt wasting

Increased circulating androstenedione concentration

Increased circulating dehydroepiandrosterone-sulfate concentration

Increased serum testosterone level

Increased circulating 17 hydroxypregnenolone concentration

Elevated circulating 17-hydroxyprogesterone concentration

Elevated circulating 21-deoxycortisol concentration

Elevated serum 11-deoxycortisol

Disease(s) Associated with CYP17A1

congenital adrenal hyperplasia

pancreatic cancer

Mouse Phenotypes		increased circulating creatinine level	increased blood urea nitrogen level	increased fasting circulating glucose level	decreased circulating testosterone level	increased circulating HDL cholesterol level	increased circulating cholesterol level	decreased circulating phosphate level	increased circulating alkaline phosphatase level	improved glucose tolerance	abnormal testosterone level
Availability	Mouse Genotype	increased circulating creatinine level	increased blood urea nitrogen level	increased fasting circulating glucose level	decreased circulating testosterone level	increased circulating HDL cholesterol level	increased circulating cholesterol level	decreased circulating phosphate level	increased circulating alkaline phosphatase level	improved glucose tolerance	abnormal testosterone level
	Cyp17a1^{tm1b(EUCOMM)Wtsi}/Cyp17a1^{tm1b(EUCOMM)Wtsi}
	Cyp17a1^tm1Vpap/Cyp17a1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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