Crygb
Gene Detail

Symbol Name ID

Crygb crystallin, gamma B MGI:88522

Synonyms

Cryg-3, DGcry-3

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr1:65080228-65082267 bp, - strand From Ensembl annotation of GRCm38   2040 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygb

Human homologs

Human Homolog		CRYGB, crystallin, gamma B
NCBI Gene ID		1419
neXtProt AC		NX_P07316
Human Synonyms		CRYG2
Human Chr (Location)		2q34; chr2:209007297-209010877 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(1) Spontaneous(2) Chemically induced(1)
 

Homozygotes and heterozygotes for a spontaneous mutation exhibit cataracts characterized by nuclear and polar opacity with vacuoles and a reduction in lens weight.

 
Human Diseases Modeled Using Mouse Crygb (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	eye development, lens development in camera-type eye, ...
Component	cytoplasm, nucleus
Function	structural constituent of eye lens

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (69)    Tissues (35)    Images (14)
Theiler Stages: 16, 19, 20, 23, 24, 28

Assay Type	Results
RNA in situ	43
Northern blot	15
RT-PCR	11

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) Genomic(1) cDNA(8) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000073658 (Evidence)
Entrez Gene	12965 (Evidence)
DFCI	TC1577728
DoTS	DT.102557133, DT.534192
NIA Mouse Gene Index	U148181
Consensus CDS Project	CCDS15013.1
International Mouse Knockout Project Status	Crygb

Sequences

Length	Strain/Species
genomic	ENSMUSG00000073658	Ensembl Gene Model | MGI Sequence Detail	2040	C57BL/6J
transcript	ENSMUST00000027090	Ensembl | MGI Sequence Detail	604	Not Applicable
polypeptide	ENSMUSP00000027090	Ensembl | MGI Sequence Detail	175	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001064	Beta/gamma crystallin
InterPro	IPR011024	Gamma-crystallin-related
Protein Ontology	PR:000005915	gamma-crystallin B

References

(Earliest) J:6796 Shinohara T, et al., Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning. Proc Natl Acad Sci U S A. 1982 May;79(9):2783-7
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(57)

Other accession IDs

MGD-MRK-2172, MGD-MRK-2177, MGD-MRK-8838