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Crygb
Gene Detail
Symbol

Name
ID
Member of
Crygb
crystallin, gamma B
MGI:88522
Cryg cluster
Synonyms
Cryg-3, DGcry-3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr1:65080219-65082288 bp, - strand
From VEGA annotation of GRCm38

  2070 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: CRYGB
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crygb

Human
homologs
CRYGB, crystallin, gamma B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1419
neXtProt AC: NX_P07316

Human Synonyms: CRYG2, CTRCT39

Human Chr (Location): 2q34; chr2:208142573-208146153 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYGB

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes and heterozygotes for a spontaneous mutation exhibit cataracts characterized by nuclear and polar opacity with vacuoles and a reduction in lens weight.
 
Human Diseases Modeled in Mice Using Crygb (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(2)
Interactions
Crygb interacts with 25 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process eye development, lens development in camera-type eye, ...
Component cytoplasm, nucleus
Function structural constituent of eye lens
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (69)    Tissues (36)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
Northern blot 15
RT-PCR 11
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crygb    NEW 
Molecular
reagents
All nucleic(69) Genomic(1) cDNA(65) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000047625 (Evidence)
Ensembl Gene Model ENSMUSG00000073658 (Evidence)
Entrez Gene 12965 (Evidence)
UniGene 440053
DFCI TC1577728
DoTS DT.102557133, DT.534192
NIA Mouse Gene Index U148181
Consensus CDS Project CCDS15013.1
International Mouse Phenotyping Consortium Status Crygb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047625 VEGA Gene Model | MGI Sequence Detail 2070 C57BL/6J ±  kb
transcript OTTMUST00000122786 VEGA | MGI Sequence Detail 634 Not Applicable 
polypeptide OTTMUSP00000067246 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(21 from dbSNP Build 137)    SNPs within 2kb including multiple locations(25)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005915 gamma-crystallin B
References
(Earliest) J:6796 Shinohara T, et al., Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning. Proc Natl Acad Sci U S A. 1982 May;79(9):2783-7
(Latest) J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
All references(58)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-2172, MGD-MRK-2177, MGD-MRK-8838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory