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Crygb Gene Detail
Summary
  • Symbol
    Crygb
  • Name
    crystallin, gamma B
  • Synonyms
    Cryg-3, DGcry-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88522
    NCBI Gene: 12965
  • Member of
    Cryg cluster
  • Gene Overview
    MyGene.info: CRYGB
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65080222-65082290 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.82 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88522
protein coding gene Chr1:65080219-65082290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016104
protein coding gene Chr1:65277845-65279914 (-)
A/J MGP_AJ_G0016087
protein coding gene Chr1:62976802-62978871 (-)
AKR/J MGP_AKRJ_G0016044
protein coding gene Chr1:64738867-64740936 (-)
BALB/cJ MGP_BALBcJ_G0016042
protein coding gene Chr1:63072122-63074191 (-)
C3H/HeJ MGP_C3HHeJ_G0015873
protein coding gene Chr1:65013719-65015788 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016495
protein coding gene Chr1:67801284-67803353 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014216
protein coding gene Chr1:59030119-59032114 (-)
CAST/EiJ MGP_CASTEiJ_G0015457
protein coding gene Chr1:64282953-64285017 (-)
CBA/J MGP_CBAJ_G0015846
protein coding gene Chr1:70005931-70008000 (-)
DBA/2J MGP_DBA2J_G0015947
protein coding gene Chr1:62378282-62380351 (-)
FVB/NJ MGP_FVBNJ_G0015950
protein coding gene Chr1:61651506-61653575 (-)
LP/J MGP_LPJ_G0016019
protein coding gene Chr1:66178036-66180105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015970
protein coding gene Chr1:72856039-72858108 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016542
protein coding gene Chr1:64727666-64729735 (-)
PWK/PhJ MGP_PWKPhJ_G0015243
protein coding gene Chr1:61778483-61780563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015023
protein coding gene Chr1:64209461-64211527 (-)
WSB/EiJ MGP_WSBEiJ_G0015519
protein coding gene Chr1:64435814-64437883 (-)



Homology
more
  • Human Ortholog
    CRYGB, crystallin gamma B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CRYGB, crystallin gamma B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRYG2, CTRCT39
  • Links
    NCBI Gene ID: 1419
    neXtProt AC: NX_P07316
    UniProt: P07316

  • Chr Location
    2q33.3; chr2:208142573-208146327 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Crygb mouse models; 1 with human CRYGB associations

Human Disease Mouse Models
      
IDs
View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for a spontaneous mutation exhibit cataracts characterized by nuclear and polar opacity with vacuoles and a reduction in lens weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12965 NCBI Gene Model | MGI Sequence Detail 2069 C57BL/6J ±  kb
    transcript NM_144761 RefSeq | MGI Sequence Detail 633 C57BL/6  
    polypeptide P04344 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 1
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2172, MGD-MRK-2177, MGD-MRK-8838
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 14
      Diseases 3
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:251150 Aoki H, et al., Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory