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Cpa1 Gene Detail
Summary
  • Symbol
    Cpa1
  • Name
    carboxypeptidase A1, pancreatic
  • Synonyms
    0910001L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88478
    NCBI Gene: 109697
  • Gene Overview
    MyGene.info: CPA1
Location & Maps
more
  • Sequence Map
    Chr6:30639218-30645363 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6146 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.52 cM, cytoband B1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    24 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CPA1, carboxypeptidase A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CPA1, carboxypeptidase A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPA
  • Links
    NCBI Gene ID: 1357
    neXtProt AC: NX_P15085

  • Chr Location
    7q32; chr7:130380371-130388108 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-in allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014402 VEGA Gene Model | MGI Sequence Detail 6146 C57BL/6J ±  kb
transcript OTTMUST00000034113 VEGA | MGI Sequence Detail 1583 Not Applicable  
polypeptide OTTMUSP00000015291 VEGA | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005795 carboxypeptidase A1
  • EC
  • InterPro Domains
    IPR000834 Peptidase M14, carboxypeptidase A
    IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
    IPR009020 Proteinase inhibitor, propeptide
Molecular
Reagents
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  • All nucleic 371
    Genomic 1
    cDNA 362
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-2102, MGI:1913347
References
more
  • Summaries
    All 113
    Developmental Gene Expression 62
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:4779 Honey NK, et al., Assignment in mouse of the genes for chymotrypsinogen B, elastase, trypsin, and carboxypeptidase A (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):492-493 (Abstr.) (399-616)
  • Latest
    J:229014 Marty-Santos L, et al., Pdx1 regulates pancreas tubulogenesis and E-cadherin expression. Development. 2016 Jan 1;143(1):101-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory