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Cpa1 Gene Detail
Summary
  • Symbol
    Cpa1
  • Name
    carboxypeptidase A1, pancreatic
  • Synonyms
    0910001L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88478
    NCBI Gene: 109697
  • Alliance
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30639217-30645360 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.52 cM, cytoband B1
  • Mapping Data
    24 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88478
protein coding gene Chr6:30639217-30645362 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030542
protein coding gene Chr6:28540712-28546857 (+)
A/J MGP_AJ_G0030515
protein coding gene Chr6:27308027-27314172 (+)
AKR/J MGP_AKRJ_G0030442
protein coding gene Chr6:28224720-28230864 (+)
BALB/cJ MGP_BALBcJ_G0030525
protein coding gene Chr6:27459082-27465227 (+)
C3H/HeJ MGP_C3HHeJ_G0030238
protein coding gene Chr6:28215688-28221834 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030979
protein coding gene Chr6:29343915-29350060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028190
protein coding gene Chr6:25503955-25510094 (+)
CAST/EiJ MGP_CASTEiJ_G0029640
protein coding gene Chr6:28033180-28039339 (+)
CBA/J MGP_CBAJ_G0030216
protein coding gene Chr6:30469367-30475511 (+)
DBA/2J MGP_DBA2J_G0030360
protein coding gene Chr6:27237819-27243963 (+)
FVB/NJ MGP_FVBNJ_G0030314
protein coding gene Chr6:27003226-27009371 (+)
LP/J MGP_LPJ_G0030447
protein coding gene Chr6:28671963-28678108 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030350
protein coding gene Chr6:32893312-32899457 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031009
protein coding gene Chr6:28098507-28104652 (+)
PWK/PhJ MGP_PWKPhJ_G0029354
protein coding gene Chr6:26816660-26822789 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029190
protein coding gene Chr6:27843319-27849484 (+)
WSB/EiJ MGP_WSBEiJ_G0029716
protein coding gene Chr6:28066864-28073018 (+)



Homology
more
  • Human Ortholog
    CPA1, carboxypeptidase A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPA1, carboxypeptidase A1
  • Synonyms
    CPA
  • Links
    NCBI Gene ID: 1357
    neXtProt AC: NX_P15085
    UniProt: P15085

  • Chr Location
    7q32.2; chr7:130380371-130388108 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cpa1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight decreased in circulating amylase level. Mice homozygous for an amino acid substitution exhibit progressive, chronic pancreatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109697 NCBI Gene Model | MGI Sequence Detail 6144 C57BL/6J ±  kb
    transcript NM_025350 RefSeq | MGI Sequence Detail 1594 C57BL/6  
    polypeptide Q7TPZ8 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 373
      Genomic 1
      cDNA 363
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2102, MGI:1913347
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 90
      Diseases 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:4779 Honey NK, et al., Assignment in mouse of the genes for chymotrypsinogen B, elastase, trypsin, and carboxypeptidase A (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):492-493 (Abstr.) (399-616)
    • Latest
      J:323941 Nemeth BC, et al., Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop. Sci Rep. 2022 Apr 15;12(1):6357

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/23/2022
    MGI 6.20
    The Jackson Laboratory