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Cpa1 Gene Detail
Summary
  • Symbol
    Cpa1
  • Name
    carboxypeptidase A1, pancreatic
  • Synonyms
    0910001L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88478
    NCBI Gene: 109697
  • Gene Overview
    MyGene.info: CPA1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30639218-30645361 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.52 cM, cytoband B1
  • Mapping Data
    24 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88478
protein coding gene Chr6:30639218-30645363 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030542
protein coding gene Chr6:28540712-28546857 (+)
A/J MGP_AJ_G0030515
protein coding gene Chr6:27308027-27314172 (+)
AKR/J MGP_AKRJ_G0030442
protein coding gene Chr6:28224720-28230864 (+)
BALB/cJ MGP_BALBcJ_G0030525
protein coding gene Chr6:27459082-27465227 (+)
C3H/HeJ MGP_C3HHeJ_G0030238
protein coding gene Chr6:28215688-28221834 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030979
protein coding gene Chr6:29343915-29350060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028190
protein coding gene Chr6:25503955-25510094 (+)
CAST/EiJ MGP_CASTEiJ_G0029640
protein coding gene Chr6:28033180-28039339 (+)
CBA/J MGP_CBAJ_G0030216
protein coding gene Chr6:30469367-30475511 (+)
DBA/2J MGP_DBA2J_G0030360
protein coding gene Chr6:27237819-27243963 (+)
FVB/NJ MGP_FVBNJ_G0030314
protein coding gene Chr6:27003226-27009371 (+)
LP/J MGP_LPJ_G0030447
protein coding gene Chr6:28671963-28678108 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030350
protein coding gene Chr6:32893312-32899457 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031009
protein coding gene Chr6:28098507-28104652 (+)
PWK/PhJ MGP_PWKPhJ_G0029354
protein coding gene Chr6:26816660-26822789 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029190
protein coding gene Chr6:27843319-27849484 (+)
WSB/EiJ MGP_WSBEiJ_G0029716
protein coding gene Chr6:28066864-28073018 (+)



Homology
more
  • Human Ortholog
    CPA1, carboxypeptidase A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CPA1, carboxypeptidase A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPA
  • Links
    NCBI Gene ID: 1357
    neXtProt AC: NX_P15085
    UniProt: P15085

  • Chr Location
    7q32.2; chr7:130380371-130388108 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-in allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 109697 NCBI Gene Model | MGI Sequence Detail 6144 C57BL/6J ±  kb
transcript NM_025350 RefSeq | MGI Sequence Detail 1594 C57BL/6  
polypeptide Q7TPZ8 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 372
    Genomic 1
    cDNA 363
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2102, MGI:1913347
References
more
  • Summaries
    All 126
    Developmental Gene Expression 73
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:4779 Honey NK, et al., Assignment in mouse of the genes for chymotrypsinogen B, elastase, trypsin, and carboxypeptidase A (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):492-493 (Abstr.) (399-616)
  • Latest
    J:253982 Norlin S, et al., The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory