Cpa1^tm1.1Satom
Targeted Allele Detail

Summary

• Symbol: Cpa1^tm1.1Satom
• Name: carboxypeptidase A1, pancreatic; targeted mutation 1.1, Miklos Sahin-Toth
• MGI ID: MGI:6501733
• Synonyms: CPA1 N256K
• Gene: Cpa1 Location: Chr6:30639217-30645360 bp, + strand Genetic Position: Chr6, 12.52 cM, cytoband B1
• Alliance: Cpa1^tm1.1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300037
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 7 was replaced with a floxed neomycin resistance cassette and exon 7 mutated to produced the nucleotide substitution of asparagine with lysine at position 256 (N256K). Cre-mediated recombination removed the selection cassette and allowed for expression of the mutated allele. This mutation is present in human patients with pancreatitis. (J:300037)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpa1 Mutation: 25 strains or lines available

References

• Original: J:300037 Orekhova A, et al., Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice. Am J Physiol Gastrointest Liver Physiol. 2020;318(4):G694-G704
• All: 3 reference(s)