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Cnp Gene Detail
Summary
  • Symbol
    Cnp
  • Name
    2',3'-cyclic nucleotide 3' phosphodiesterase
  • Synonyms
    Cnp1, Cnp-1, CNPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88437
    NCBI Gene: 12799
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100574904-100591729 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88437
 protein coding gene Chr11:100574904-100591875 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019160
 protein coding gene Chr11:103337618-103354430 (+)
A/J MGP_AJ_G0019128
 protein coding gene Chr11:99026496-99043292 (+)
AKR/J MGP_AKRJ_G0019097
 protein coding gene Chr11:102087071-102103845 (+)
BALB/cJ MGP_BALBcJ_G0019102
 protein coding gene Chr11:99510292-99527049 (+)
C3H/HeJ MGP_C3HHeJ_G0018911
 protein coding gene Chr11:102274179-102290959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019551
 protein coding gene Chr11:106554389-106572356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017177
 protein coding gene Chr11:96445347-96462370 (+)
CAST/EiJ MGP_CASTEiJ_G0018465
 protein coding gene Chr11:103249970-103266834 (+)
CBA/J MGP_CBAJ_G0018880
 protein coding gene Chr11:110985768-111002531 (+)
DBA/2J MGP_DBA2J_G0018992
 protein coding gene Chr11:98563092-98580123 (+)
FVB/NJ MGP_FVBNJ_G0018982
 protein coding gene Chr11:98099117-98115889 (+)
LP/J MGP_LPJ_G0019061
 protein coding gene Chr11:103900319-103917078 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019013
 protein coding gene Chr11:110588610-110605387 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019589
 protein coding gene Chr11:102421248-102439095 (+)
PWK/PhJ MGP_PWKPhJ_G0018228
 protein coding gene Chr11:99603098-99619966 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018020
 protein coding gene Chr11:102156050-102172895 (+)
WSB/EiJ MGP_WSBEiJ_G0018514
 protein coding gene Chr11:102404475-102421222 (+)



Homology
more
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNP1, HLD20
  • Links
    NCBI Gene ID: 1267
    neXtProt AC: NX_P09543
    UniProt: P09543

  • Chr Location
    17q21.2; chr17:41966741-41977736 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human CNP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    72 phenotypes from multigenic genotypes
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    25
  • cDNA Data
    97
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006782 Ensembl Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
    transcript ENSMUST00000103120 Ensembl | MGI Sequence Detail 2357 Not Applicable  
    polypeptide ENSMUSP00000099409 Ensembl | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 9
      cDNA 100
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2039, MGD-MRK-2041
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 69
      Diseases 2
      Gene Ontology 12
      Phenotypes 159
    • Earliest
      J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
    • Latest
      J:297575 Guzman KM, et al., Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation. Glia. 2020 Oct;68(10):2040-2056
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory