Cnp MGI Mouse Gene Detail - MGI:88437 - 2',3'-cyclic nucleotide 3' phosphodiesterase

Cnp Gene Detail

Symbol

Cnp
Name

2',3'-cyclic nucleotide 3' phosphodiesterase
Synonyms

Cnp1, Cnp-1, CNPase

Feature Type

protein coding gene
IDs

MGI:88437
NCBI Gene: 12799
Alliance

gene page

Sequence Map

Chr11:100574904-100591729 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

16826 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.47 cM
Mapping Data

9 experiments

Human Ortholog

CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase

Vertebrate Orthologs

9

Human Ortholog

CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
Orthology source: HomoloGene, HGNC
Synonyms

CNP1
Links

HGNC:2158

NCBI Gene ID: 1267

neXtProt AC: NX_P09543

UniProt: P09543
Chr Location

17q21.2; chr17:41966741-41977736 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7672
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CNP
Protein SuperFamily

2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Tree

Cnp

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
67 phenotypes from multigenic genotypes
119 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

2
Targeted

9
Genomic Mutations

3 involving Cnp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available

Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.

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All GO Annotations

32
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

25
Tissues

13
cDNA Data

96
Literature Summary

57

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnp

ZFIN cnp

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Cnp interacts with 141 markers (Mir7-2, Mir7b, Mir16-1, ...) View All

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All Sequences

51
RefSeq

8
UniProt

4
CCDS

CCDS25427.1
UniGene

15711

			Length	Strain/Species	Flank
genomic	OTTMUSG00000002001	VEGA Gene Model \| MGI Sequence Detail	16826	C57BL/6J	± kb
transcript	OTTMUST00000004035	VEGA \| MGI Sequence Detail	2357	Not Applicable
polypeptide	OTTMUSP00000001946	VEGA \| MGI Sequence Detail	420	Not Applicable

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SNPs within 2kb

161 from dbSNP Build 142

RFLP

1

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UniProt

4 Sequences
Protein Ontology

PR:000005657 2',3'-cyclic-nucleotide 3'-phosphodiesterase

(term hierarchy)
PDB

2XMI, 2Y1P, 2Y3X, 2YDB, 2YDC, 2YDD, 2YOZ, 2YP0, 2YPC, 2YPE, 2YPH, 2YQ9, 3ZBR, 3ZBS, 3ZBZ, 4WBI, 4WBL, 4WC9, 4WCA, 4WCB, 4WCC, 4WDA, 4WDB, 4WDD, 4WDE, 4WDF, 4WDG, 4WDH, 4WEX, 4WFR, 5AE0
EC

3.1.4.37
InterPro Domains

IPR008431 Cyclic nucleotide phosphodiesterase

IPR009097 Cyclic phosphodiesterase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 109

Genomic 9

cDNA 99

Other 1

Microarray probesets 4

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MGD-MRK-2039, MGD-MRK-2041

Summaries

All 220

Developmental Gene Expression 57

Gene Ontology 10

Phenotypes 119
Earliest

J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
Latest

J:258339 Janova H, et al., Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest. 2018 Feb 1;128(2):734-745

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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