Cnp MGI Mouse Gene Detail - MGI:88437 - 2',3'-cyclic nucleotide 3' phosphodiesterase

Symbol

Cnp
Name

2',3'-cyclic nucleotide 3' phosphodiesterase
Synonyms

Cnp1, Cnp-1, CNPase

Feature Type

protein coding gene
IDs

MGI:88437
NCBI Gene: 12799
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:100574909-100591418 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.47 cM
Mapping Data

9 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88437	protein coding gene	Chr11:100574904-100591729 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019160	protein coding gene	Chr11:103337618-103354430 (+)
A/J	MGP_AJ_G0019128	protein coding gene	Chr11:99026496-99043292 (+)
AKR/J	MGP_AKRJ_G0019097	protein coding gene	Chr11:102087071-102103845 (+)
BALB/cJ	MGP_BALBcJ_G0019102	protein coding gene	Chr11:99510292-99527049 (+)
C3H/HeJ	MGP_C3HHeJ_G0018911	protein coding gene	Chr11:102274179-102290959 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019551	protein coding gene	Chr11:106554389-106572356 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017177	protein coding gene	Chr11:96445347-96462370 (+)
CAST/EiJ	MGP_CASTEiJ_G0018465	protein coding gene	Chr11:103249970-103266834 (+)
CBA/J	MGP_CBAJ_G0018880	protein coding gene	Chr11:110985768-111002531 (+)
DBA/2J	MGP_DBA2J_G0018992	protein coding gene	Chr11:98563092-98580123 (+)
FVB/NJ	MGP_FVBNJ_G0018982	protein coding gene	Chr11:98099117-98115889 (+)
LP/J	MGP_LPJ_G0019061	protein coding gene	Chr11:103900319-103917078 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019013	protein coding gene	Chr11:110588610-110605387 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019589	protein coding gene	Chr11:102421248-102439095 (+)
PWK/PhJ	MGP_PWKPhJ_G0018228	protein coding gene	Chr11:99603098-99619966 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018020	protein coding gene	Chr11:102156050-102172895 (+)
WSB/EiJ	MGP_WSBEiJ_G0018514	protein coding gene	Chr11:102404475-102421222 (+)

Human Ortholog

CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase

Vertebrate Orthologs

9

Human Ortholog

CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
Orthology source: HomoloGene, HGNC
Synonyms

CNP1
Links

HGNC:2158

NCBI Gene ID: 1267

neXtProt AC: NX_P09543

UniProt: P09543
Chr Location

17q21.2; chr17:41966741-41977736 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7672
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CNP
Protein SuperFamily

2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Tree

Cnp

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Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
72 phenotypes from multigenic genotypes
143 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

2
Targeted

9
Genomic Mutations

3 involving Cnp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.

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All GO Annotations

34
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

37
Tissues

18
cDNA Data

97
Literature Summary

63

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnp

ZFIN cnp

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Cnp interacts with 141 markers (Mir7-2, Mir7b, Mir16-1, ...) View All

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All Sequences

63
RefSeq

8
UniProt

4
CCDS

CCDS25427.1
UniGene

15711

Ensembl

ENSMUSG00000006782 (Evidence)
NCBI Gene

12799

			Length	Strain/Species	Flank
genomic	12799	NCBI Gene Model \| MGI Sequence Detail	16510	C57BL/6J	± kb
transcript	NM_001146318	RefSeq \| MGI Sequence Detail	2548	C57BL/6
polypeptide	P16330	UniProt \| EBI \| MGI Sequence Detail	420	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005657 2',3'-cyclic-nucleotide 3'-phosphodiesterase

(term hierarchy)
PDB

2XMI, 2Y1P, 2Y3X, 2YDB, 2YDC, 2YDD, 2YOZ, 2YP0, 2YPC, 2YPE, 2YPH, 2YQ9, 3ZBR, 3ZBS, 3ZBZ, 4WBI, 4WBL, 4WC9, 4WCA, 4WCB, 4WCC, 4WDA, 4WDB, 4WDD, 4WDE, 4WDF, 4WDG, 4WDH, 4WEX, 4WFR, 5AE0
EC

3.1.4.37
InterPro Domains

IPR008431 Cyclic nucleotide phosphodiesterase

IPR009097 Cyclic phosphodiesterase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 110

Genomic 9

cDNA 100

Other 1

Microarray probesets 4

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MGD-MRK-2039, MGD-MRK-2041

Summaries

All 253

Developmental Gene Expression 63

Diseases 2

Gene Ontology 12

Phenotypes 143
Earliest

J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
Latest

J:278196 Joseph S, et al., Myelinating Glia-Specific Deletion of Fbxo7 in Mice Triggers Axonal Degeneration in the Central Nervous System Together with Peripheral Neuropathy. J Neurosci. 2019 Jul 10;39(28):5606-5626

TSS for Cnp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104944	Chr11:100574965-100574982 (+)	65 bp
Tssr104945	Chr11:100575797-100575815 (+)	897 bp
Tssr104946	Chr11:100575882-100575900 (+)	982 bp
Tssr104947	Chr11:100580789-100580814 (+)	5,893 bp
Tssr104948	Chr11:100580828-100580851 (+)	5,931 bp
Tssr104949	Chr11:100580884-100580889 (+)	5,978 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14