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Cnp
Gene Detail
Symbol

Name
ID
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
MGI:88437
Synonyms
Cnp1, Cnp-1, CNPase
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr11:100574904-100591729 bp, + strand
From VEGA annotation of GRCm38

  16826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CNP
Protein SuperFamily: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Tree: Cnp

Human
homologs
CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1267
neXtProt AC: NX_P09543

Human Synonyms: CNP1

Human Chr (Location): 17q21; chr17:41966741-41977736 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Genomic Mutations involving Cnp (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.
 
Interactions
Cnp interacts with 141 markers (Mir7-2, Mir7b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process adult locomotory behavior, axonogenesis, ...
Component cell projection, cytoplasm, ...
Function 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity, cyclic nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (25)    Tissues (13)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 15
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cnp ; ZFIN cnp    NEW 
Molecular
reagents
All nucleic(109) Genomic(9) cDNA(99) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002001 (Evidence)
Ensembl Gene Model ENSMUSG00000006782 (Evidence)
Entrez Gene 12799 (Evidence)
UniGene 15711
DFCI TC1573952
DoTS DT.101402473, DT.101402474, DT.101402475, DT.94124923, DT.94408206, DT.97414133, DT.97414137
NIA Mouse Gene Index U013341
EC 3.1.4.37
PDB 2XMI, 2Y1P, 2Y3X, 2YDB, 2YDC, 2YDD, 2YOZ, 2YPC, 2YPE, 2YPH, 3ZBR, 3ZBS, 3ZBZ, 2YP0, 2YQ9
Consensus CDS Project CCDS25427.1
International Mouse Phenotyping Consortium Status Cnp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002001 VEGA Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
transcript OTTMUST00000004035 VEGA | MGI Sequence Detail 2357 Not Applicable 
polypeptide OTTMUSP00000001946 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008431 Cyclic nucleotide phosphodiesterase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
Protein Ontology PR:000005657 2',3'-cyclic-nucleotide 3'-phosphodiesterase
References
(Earliest) J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
(Latest) J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22
All references(167)
Other
accession IDs
MGD-MRK-2039, MGD-MRK-2041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory