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Cnp Gene Detail
Summary
  • Symbol
    Cnp
  • Name
    2',3'-cyclic nucleotide 3' phosphodiesterase
  • Synonyms
    Cnp1, Cnp-1, CNPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88437
    NCBI Gene: 12799
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:100574904-100591729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16826 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNP1
  • Links
    NCBI Gene ID: 1267
    neXtProt AC: NX_P09543
    UniProt: P09543

  • Chr Location
    17q21.2; chr17:41966741-41977736 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    67 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    25
  • Tissues
    13
  • cDNA Data
    96
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002001 VEGA Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
    transcript OTTMUST00000004035 VEGA | MGI Sequence Detail 2357 Not Applicable  
    polypeptide OTTMUSP00000001946 VEGA | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      161 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      Genomic 9
      cDNA 99
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2039, MGD-MRK-2041
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 57
      Gene Ontology 10
      Phenotypes 122
    • Earliest
      J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
    • Latest
      J:261981 Zemmar A, et al., Oligodendrocyte- and Neuron-Specific Nogo-A Restrict Dendritic Branching and Spine Density in the Adult Mouse Motor Cortex. Cereb Cortex. 2018 Jun 1;28(6):2109-2117
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory