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Cnp Gene Detail
Summary
  • Symbol
    Cnp
  • Name
    2',3'-cyclic nucleotide 3' phosphodiesterase
  • Synonyms
    Cnp1, Cnp-1, CNPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88437
    NCBI Gene: 12799
  • Alliance
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:100465765-100472565 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88437
protein coding gene Chr11:100465730-100482555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019160
protein coding gene Chr11:103337618-103354430 (+)
A/J MGP_AJ_G0019128
protein coding gene Chr11:99026496-99043292 (+)
AKR/J MGP_AKRJ_G0019097
protein coding gene Chr11:102087071-102103845 (+)
BALB/cJ MGP_BALBcJ_G0019102
protein coding gene Chr11:99510292-99527049 (+)
C3H/HeJ MGP_C3HHeJ_G0018911
protein coding gene Chr11:102274179-102290959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019551
protein coding gene Chr11:106554389-106572356 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017177
protein coding gene Chr11:96445347-96462370 (+)
CAST/EiJ MGP_CASTEiJ_G0018465
protein coding gene Chr11:103249970-103266834 (+)
CBA/J MGP_CBAJ_G0018880
protein coding gene Chr11:110985768-111002531 (+)
DBA/2J MGP_DBA2J_G0018992
protein coding gene Chr11:98563092-98580123 (+)
FVB/NJ MGP_FVBNJ_G0018982
protein coding gene Chr11:98099117-98115889 (+)
LP/J MGP_LPJ_G0019061
protein coding gene Chr11:103900319-103917078 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019013
protein coding gene Chr11:110588610-110605387 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019589
protein coding gene Chr11:102421248-102439095 (+)
PWK/PhJ MGP_PWKPhJ_G0018228
protein coding gene Chr11:99603098-99619966 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018020
protein coding gene Chr11:102156050-102172895 (+)
WSB/EiJ MGP_WSBEiJ_G0018514
protein coding gene Chr11:102404475-102421222 (+)



Homology
more
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
  • Synonyms
    CNP1, HLD20
  • Links
    NCBI Gene ID: 1267
    neXtProt AC: NX_P09543
    UniProt: P09543

  • Chr Location
    17q21.2; chr17:41966763-41977740 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human CNP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    77 phenotypes from multigenic genotypes
    191 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12799 NCBI Gene Model | MGI Sequence Detail 6801 C57BL/6J ±  kb
    transcript NM_001146318 RefSeq | MGI Sequence Detail 2548 ZRU/MplStud  
    polypeptide P16330 UniProt | EBI | MGI Sequence Detail 420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 9
      cDNA 100
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2039, MGD-MRK-2041
    References
    more
    • Summaries
      All 321
      Developmental Gene Expression 81
      Diseases 2
      Gene Ontology 12
      Phenotypes 191
    • Earliest
      J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
    • Latest
      J:341709 Zhang T, et al., Autophagy collaborates with apoptosis pathways to control oligodendrocyte number. Cell Rep. 2023 Aug 29;42(8):112943

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory