Cnp
Gene Detail

Symbol Name ID

Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase MGI:88437

Synonyms

Cnp1, Cnp-1, CNPase

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr11:100574904-100591729 bp, + strand From VEGA annotation of GRCm38   16826 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7672  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
Gene Tree: Cnp

Human homologs

Human Homolog		CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI Gene ID		1267
neXtProt AC		NX_P09543
Human Synonyms		CNP1
Human Chr (Location)		17q21; chr17:41966741-41977740 (+)  GRCh38

Alleles and phenotypes

All alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	adult locomotory behavior, axonogenesis, ...
Component	cell projection, cytoplasm, ...
Function	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)

Data Summary: Results (24)    Tissues (13)    Images (6)
Theiler Stages: 20, 21, 22, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	15

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(109) Genomic(9) cDNA(99) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000002001 (Evidence)
Ensembl Gene Model	ENSMUSG00000006782 (Evidence)
Entrez Gene	12799 (Evidence)
UniGene	15711
DFCI	TC1573952
DoTS	DT.101402473, DT.101402474, DT.101402475, DT.94124923, DT.94408206, DT.97414133, DT.97414137
NIA Mouse Gene Index	U013341
EC	3.1.4.37
PDB	2XMI, 2Y1P, 2Y3X, 2YDB, 2YDC, 2YDD, 2YOZ, 2YPC, 2YPE, 2YPH, 3ZBR, 3ZBS, 3ZBZ, 2YP0, 2YQ9
Consensus CDS Project	CCDS25427.1
International Mouse Knockout Project Status	Cnp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002001	VEGA Gene Model | MGI Sequence Detail	16826	C57BL/6J
transcript	OTTMUST00000004035	VEGA | MGI Sequence Detail	2357	Not Applicable
polypeptide	OTTMUSP00000001946	VEGA | MGI Sequence Detail	420	Not Applicable

All sequences(60) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(161 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR008431	Cyclic nucleotide phosphodiesterase
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR009097	RNA ligase/cyclic nucleotide phosphodiesterase
Protein Ontology	PR:000005657	2',3'-cyclic-nucleotide 3'-phosphodiesterase

References

(Earliest) J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
(Latest) J:210457 Wahl SE, et al., Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014 Mar 26;34(13):4453-65
All references(150)

Other accession IDs

MGD-MRK-2039, MGD-MRK-2041