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Cnp Gene Detail
Summary
  • Symbol
    Cnp
  • Name
    2',3'-cyclic nucleotide 3' phosphodiesterase
  • Synonyms
    Cnp1, Cnp-1, CNPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88437
    NCBI Gene: 12799
Location & Maps
more
  • Sequence Map
    Chr11:100574904-100591729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      16826 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNP1
  • Links
    NCBI Gene ID: 1267
    neXtProt AC: NX_P09543

  • Chr Location
    17q21; chr17:41966741-41977736 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    66 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
  • Genomic Mutations
    1 involving Cnp
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygous inactivation of this gene results in ataxia, gait abnormalities, hindlimb paralysis, muscle weakness, convulsive seizures, weight loss, kyphosis, reactive gliosis, axonal swellings and degeneration, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    25
  • Tissues
    13
  • cDNA Data
    96
  • Literature Summary
    54
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002001 VEGA Gene Model | MGI Sequence Detail 16826 C57BL/6J ±  kb
transcript OTTMUST00000004035 VEGA | MGI Sequence Detail 2357 Not Applicable  
polypeptide OTTMUSP00000001946 VEGA | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    161 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    Genomic 9
    cDNA 99
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2039, MGD-MRK-2041
References
more
  • Summaries
    All 180
    Developmental Gene Expression 54
    Gene Ontology 10
    Phenotypes 90
  • Earliest
    J:32316 Bernier L, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues. J Neurosci. 1987 Sep;7(9):2703-10
  • Latest
    J:234565 He D, et al., Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nat Neurosci. 2016 May;19(5):678-89
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory