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Chrm2
Gene Detail
Symbol

Name
ID
Chrm2
cholinergic receptor, muscarinic 2, cardiac
MGI:88397
Synonyms
AChR M2, Chrm-2, M2, muscarinic acetylcholine receptor 2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
15.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:36388084-36528414 bp, + strand
From VEGA annotation of GRCm38

  140331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20190  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHRM2
Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm2

Human
homologs
CHRM2, cholinergic receptor, muscarinic 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1129
neXtProt AC: NX_P08172

Human Synonyms: HM2

Human Chr (Location): 7q31-q35; chr7:136868652-137020255 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have slightly decreased body weight (5%) compared to wild-type animals and are resistant to the tremorogenic, analgesic, and hypothermic responses to oxotremorine.
 
Interactions
Chrm2 interacts with 410 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (217)    Tissues (58)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 210
RT-PCR 7
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chrm2    NEW 
Molecular
reagents
All nucleic(5) cDNA(3) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000036825 (Evidence)
Ensembl Gene Model ENSMUSG00000045613 (Evidence)
Entrez Gene 243764 (Evidence)
UniGene 448632
DFCI TC1605328
DoTS DT.91312177
NIA Mouse Gene Index U050542
Consensus CDS Project CCDS20004.1
International Mouse Phenotyping Consortium Status Chrm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036825 VEGA Gene Model | MGI Sequence Detail 140331 C57BL/6J ±  kb
transcript OTTMUST00000094551 VEGA | MGI Sequence Detail 5676 Not Applicable 
polypeptide OTTMUSP00000052619 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(937 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR001065 Muscarinic acetylcholine receptor M2
Protein Ontology PR:000001614 muscarinic acetylcholine receptor M2
References
(Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:214125 Chen SR, et al., Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16;289(20):14321-30
All references(89)
Other
accession IDs
MGD-MRK-1975, MGD-MRK-1979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory