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Chrm2
Gene Detail
 Symbol
Name
ID
Chrm2
cholinergic receptor, muscarinic 2, cardiac
MGI:88397
Synonyms AChR M2, Chrm-2, M2, muscarinic acetylcholine receptor 2
Feature Type protein coding gene
Genetic Map
Chromosome 6
15.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:36388084-36528414 bp, + strand
From VEGA annotation of GRCm38

  140331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20190  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: muscarinic acetylcholine receptor
Gene Tree: Chrm2

Human
homologs
Human Homolog CHRM2, cholinergic receptor, muscarinic 2
NCBI Gene ID 1129
neXtProt AC  NX_P08172
Human Synonyms  HM2
Human Chr (Location)  7q31-q35; chr7:136868652-137017024 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have slightly decreased body weight (5%) compared to wild-type animals and are resistant to the tremorogenic, analgesic, and hypothermic responses to oxotremorine.
 
Interactions
Chrm2 interacts with 411 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process G-protein coupled acetylcholine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cell junction, integral component of membrane, ...
Function G-protein coupled acetylcholine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (217)    Tissues (58)    Images (37)
Theiler Stages: 12, 14, 18, 19, 21, 23, 25, 28
Assay TypeResults
RNA in situ 210
RT-PCR 7
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(3) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000036825 (Evidence)
Ensembl Gene ModelENSMUSG00000045613 (Evidence)
Entrez Gene243764 (Evidence)
UniGene448632
DFCITC1605328
DoTSDT.91312177
NIA Mouse Gene IndexU050542
Consensus CDS ProjectCCDS20004.1
International Mouse Knockout Project StatusChrm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036825 VEGA Gene Model | MGI Sequence Detail 140331 C57BL/6J ±  kb
transcript OTTMUST00000094551 VEGA | MGI Sequence Detail 5676 Not Applicable 
polypeptide OTTMUSP00000052619 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(937 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000995 Muscarinic acetylcholine receptor family
InterPro IPR001065 Muscarinic acetylcholine receptor M2
Protein Ontology PR:000001614 muscarinic acetylcholine receptor M2
References (Earliest) J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
(Latest) J:197883 Csaba Z, et al., Postsynaptic muscarinic m2 receptors at cholinergic and glutamatergic synapses of mouse brainstem motoneurons. J Comp Neurol. 2013 Jun 15;521(9):2008-24
All references(87)
Other
accession IDs
MGD-MRK-1975, MGD-MRK-1979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory