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Chrm2 Gene Detail
Summary
  • Symbol
    Chrm2
  • Name
    cholinergic receptor, muscarinic 2, cardiac
  • Synonyms
    AChR M2, Chrm-2, M2, muscarinic acetylcholine receptor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88397
    NCBI Gene: 243764
Location & Maps
more
  • Sequence Map
    Chr6:36388084-36528414 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      140331 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 15.48 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    CHRM2, cholinergic receptor muscarinic 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHRM2, cholinergic receptor muscarinic 2
    Orthology source: HomoloGene
  • Synonyms
    HM2
  • Links
    NCBI Gene ID: 1129
    neXtProt AC: NX_P08172

  • Chr Location
    7q31-q35; chr7:136868652-137020255 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have slightly decreased body weight (5%) compared to wild-type animals and are resistant to the tremorogenic, analgesic, and hypothermic responses to oxotremorine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036825 VEGA Gene Model | MGI Sequence Detail 140331 C57BL/6J ±  kb
transcript OTTMUST00000094551 VEGA | MGI Sequence Detail 5676 Not Applicable  
polypeptide OTTMUSP00000052619 VEGA | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    937 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001614 muscarinic acetylcholine receptor M2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000995 Muscarinic acetylcholine receptor family
    IPR001065 Muscarinic acetylcholine receptor M2
Molecular
Reagents
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  • All nucleic 5
    cDNA 3
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-1975, MGD-MRK-1979
References
more
  • Summaries
    All 91
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 55
  • Earliest
    J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory