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F9 Gene Detail
Summary
  • Symbol
    F9
  • Name
    coagulation factor IX
  • Synonyms
    Cf9, Cf-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:88384
    NCBI Gene: 14071
  • Gene Overview
    MyGene.info: F9
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:59999464-60030759 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A6-A7
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88384
protein coding gene ChrX:59999464-60030760 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035755
protein coding gene ChrX:55352996-55384199 (+)
A/J MGP_AJ_G0035737
protein coding gene ChrX:55560567-55592367 (+)
AKR/J MGP_AKRJ_G0035657
protein coding gene ChrX:57044272-57080673 (+)
BALB/cJ MGP_BALBcJ_G0035724
protein coding gene ChrX:54927696-54959163 (+)
C3H/HeJ MGP_C3HHeJ_G0035426
protein coding gene ChrX:55907903-55939458 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036253
protein coding gene ChrX:56830646-56871124 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033105
protein coding gene ChrX:55385238-55417683 (+)
CAST/EiJ MGP_CASTEiJ_G0034719
protein coding gene ChrX:41680766-41714873 (+)
CBA/J MGP_CBAJ_G0035401
protein coding gene ChrX:58505803-58543786 (+)
DBA/2J MGP_DBA2J_G0035555
protein coding gene ChrX:55136577-55168091 (+)
FVB/NJ MGP_FVBNJ_G0035505
protein coding gene ChrX:54680851-54711720 (+)
LP/J MGP_LPJ_G0035643
protein coding gene ChrX:55945464-55976642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035541
protein coding gene ChrX:60095530-60128368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036269
protein coding gene ChrX:55385967-55417984 (+)
PWK/PhJ MGP_PWKPhJ_G0034414
protein coding gene ChrX:39863167-39895156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034259
protein coding gene ChrX:42509978-42541193 (+)
WSB/EiJ MGP_WSBEiJ_G0034862
protein coding gene ChrX:54886884-54919077 (+)



Homology
more
  • Human Ortholog
    F9, coagulation factor IX
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F9, coagulation factor IX
    Orthology source: HGNC, HomoloGene
  • Synonyms
    F9 p22, FIX, HEMB, P19, PTC, THPH8
  • Links
    NCBI Gene ID: 2158
    neXtProt AC: NX_P00740
    UniProt: P00740

  • Chr Location
    Xq27.1; chrX:139530720-139563459 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with F9 mouse models; 1 with human F9 associations

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 8 alleles in 7 genetic backgrounds
    1 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031138 Ensembl Gene Model | MGI Sequence Detail 31296 C57BL/6J ±  kb
    transcript ENSMUST00000033477 Ensembl | MGI Sequence Detail 2734 Not Applicable  
    polypeptide ENSMUSP00000033477 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 18
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1950, MGD-MRK-1956, MGI:2147999
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 5
      Diseases 4
      Gene Ontology 7
      Phenotypes 31
    • Earliest
      J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
    • Latest
      J:263901 Khandagale A, et al., Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis. Biol Open. 2018 Jul 25;7(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory