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F9
Gene Detail
 Symbol
Name
ID
F9
coagulation factor IX
MGI:88384
Synonyms Cf9, Cf-9
Feature Type protein coding gene
Genetic Map
Chromosome X
33.50 cM, cytoband A6-A7
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
ChrX:59999464-60030759 bp, + strand
From VEGA annotation of GRCm38

  31296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F9

Human
homologs
Human Homolog F9, coagulation factor IX
NCBI Gene ID 2158
neXtProt AC  NX_P00740
Human Synonyms  FIX, HEMB, P19, PTC, THPH8
Human Chr (Location)  Xq27.1-q27.2; chrX:139530733-139565697 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human F9
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.
 
Human Diseases Modeled Using Mouse F9 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)
Interactions
F9 interacts with 184 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular vesicular exosome
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (14)   
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 26, 27, 28
Assay TypeResults
Northern blot 10
RT-PCR 14
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018393 (Evidence)
Ensembl Gene ModelENSMUSG00000031138 (Evidence)
Entrez Gene14071 (Evidence)
UniGene391283
DFCITC1600881
DoTSDT.481717
NIA Mouse Gene IndexU019879
EC3.4.21.22
Consensus CDS ProjectCCDS30158.1
International Mouse Knockout Project StatusF9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018393 VEGA Gene Model | MGI Sequence Detail 31296 C57BL/6J ±  kb
transcript OTTMUST00000044396 VEGA | MGI Sequence Detail 2734 Not Applicable 
polypeptide OTTMUSP00000019946 VEGA | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(8) : PCR(4) RFLP(4) SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007303 coagulation factor IX
References (Earliest) J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
(Latest) J:209501 Feng D, et al., FVIIa as used pharmacologically is not TF dependent in hemophilia B mice. Blood. 2014 Mar 13;123(11):1764-6
All references(79)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-1950, MGD-MRK-1956, MGI:2147999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory