F9
Gene Detail

Symbol Name ID

F9 coagulation factor IX MGI:88384

Synonyms

Cf9, Cf-9

Feature Type

protein coding gene

Genetic Map

Chromosome X

33.50 cM, cytoband A6-A7
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

ChrX:59999464-60030759 bp, + strand From VEGA annotation of GRCm38   31296 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:106  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: coagulation factor X
Gene Tree: F9

Human homologs

Human Homolog		F9, coagulation factor IX
NCBI Gene ID		2158
neXtProt AC		NX_P00740
Human Synonyms		FIX, HEMB, P19, PTC, THPH8
Human Chr (Location)		Xq27.1-q27.2; chrX:138612895-138645617 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human F9

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.

 
Human Diseases Modeled Using Mouse F9 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (13)   
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 26, 28

Assay Type	Results
Northern blot	10
RT-PCR	14

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018393 (Evidence)
Ensembl Gene Model	ENSMUSG00000031138 (Evidence)
Entrez Gene	14071 (Evidence)
UniGene	391283
DFCI	TC1600881
DoTS	DT.481717
NIA Mouse Gene Index	U019879
EC	3.4.21.22
Consensus CDS Project	CCDS30158.1
International Mouse Knockout Project Status	F9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018393	VEGA Gene Model | MGI Sequence Detail	31296	C57BL/6J
transcript	OTTMUST00000044396	VEGA | MGI Sequence Detail	2734	Not Applicable
polypeptide	OTTMUSP00000019946	VEGA | MGI Sequence Detail	471	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(8) : PCR(4) RFLP(4) SNPs(315 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000007303	coagulation factor IX

References

(Earliest) J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
(Latest) J:190917 Cantore A, et al., Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice. Blood. 2012 Nov 29;120(23):4517-20
All references(74)

Other accession IDs

MGD-MRK-1950, MGD-MRK-1956, MGI:2147999