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F9 Gene Detail
Summary
  • Symbol
    F9
  • Name
    coagulation factor IX
  • Synonyms
    Cf9, Cf-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:88384
    NCBI Gene: 14071
  • Gene Overview
    MyGene.info: F9
Location & Maps
more
  • Sequence Map
    ChrX:59999464-60030759 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31296 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A6-A7
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    F9, coagulation factor IX
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F9, coagulation factor IX
    Orthology source: HomoloGene, HGNC
  • Synonyms
    F9 p22, FIX, HEMB, P19, PTC, THPH8
  • Links
    NCBI Gene ID: 2158
    neXtProt AC: NX_P00740

  • Chr Location
    Xq27.1; chrX:139530734-139563464 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with F9 mouse models; 3 with human F9 associations

Human Disease Mouse Models
       Hemophilia B; HEMB   OMIM: 306900 View 3 models
       Coumarin Resistance   OMIM: 122700
Thrombophilia, X-Linked, Due to Factor IX Defect; THPH8   OMIM: 300807
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 6 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018393 VEGA Gene Model | MGI Sequence Detail 31296 C57BL/6J ±  kb
transcript OTTMUST00000044396 VEGA | MGI Sequence Detail 2734 Not Applicable  
polypeptide OTTMUSP00000019946 VEGA | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    312 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 17
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1950, MGD-MRK-1956, MGI:2147999
References
more
  • Summaries
    All 80
    Developmental Gene Expression 4
    Diseases 7
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
  • Latest
    J:235866 Cooley B, et al., Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice. Blood. 2016 Jul 14;128(2):286-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory