About   Help   FAQ
F9
Gene Detail
Symbol

Name
ID
F9
coagulation factor IX
MGI:88384
Synonyms
Cf9, Cf-9
Feature Type
protein coding gene
Genetic Map
Chromosome X
33.50 cM, cytoband A6-A7
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
ChrX:59999464-60030759 bp, + strand
From VEGA annotation of GRCm38

  31296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: F9
Protein SuperFamily: coagulation factor X
Gene Tree: F9

Human
homologs
F9, coagulation factor IX
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2158
neXtProt AC: NX_P00740

Human Synonyms: FIX, HEMB, P19, PTC, THPH8

Human Chr (Location): Xq27.1-q27.2; chrX:139530734-139563464 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human F9

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from CvDC )
 
Male hemizygotes for targeted null mutations are subject to fatal blood loss after tail snipping, and some affected males spontaneously die from umbilical cord bleeding. Carrier females show reduced levels of factor IX.
 
Human Diseases Modeled in Mice Using F9 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(1)
Interactions
F9 interacts with 183 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular exosome, extracellular region, ...
Function calcium ion binding, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 10
RT-PCR 14
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase f9 ; ZFIN f9a    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018393 (Evidence)
Ensembl Gene Model ENSMUSG00000031138 (Evidence)
Entrez Gene 14071 (Evidence)
UniGene 391283
DFCI TC1600881
DoTS DT.481717
NIA Mouse Gene Index U019879
EC 3.4.21.22
Consensus CDS Project CCDS30158.1
International Mouse Phenotyping Consortium Status F9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018393 VEGA Gene Model | MGI Sequence Detail 31296 C57BL/6J ±  kb
transcript OTTMUST00000044396 VEGA | MGI Sequence Detail 2734 Not Applicable 
polypeptide OTTMUSP00000019946 VEGA | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(8) : PCR(4) RFLP(4) SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000007303 coagulation factor IX
References
(Earliest) J:8649 Avner P, et al., Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1629-33
(Latest) J:222027 Wang X, et al., Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells. Blood. 2015 Apr 9;125(15):2418-27
All references(79)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-1950, MGD-MRK-1956, MGI:2147999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory