F2 MGI Mouse Gene Detail - MGI:88380

Symbol

F2
Name

coagulation factor II
Synonyms

Cf-2, Cf2, FII, prothrombin, thrombin

Feature Type

protein coding gene
IDs

MGI:88380
NCBI Gene: 14061
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:91455665-91466759 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.63 cM
Mapping Data

5 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88380	protein coding gene	Chr2:91442742-91466799 (-)
129S1/SvImJ	ENSMUSG00200052283	protein coding gene	Chr2:88371271-88382370 (-)
A/J	ENSMUSG00195050072	protein coding gene	Chr2:88507210-88518303 (-)
AKR/J	ENSMUSG00220048511	protein coding gene	Chr2:88301156-88312250 (-)
BALB/cJ	ENSMUSG00180054727	protein coding gene	Chr2:88407412-88418495 (-)
C3H/HeJ	ENSMUSG00175053320	protein coding gene	Chr2:88667107-88678204 (-)
C57BL/6NJ	ENSMUSG00215051724	protein coding gene	Chr2:88498451-88509547 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023964	protein coding gene	Chr2:85741843-85754197 (-)
CAST/EiJ	ENSTCUG00005052443	protein coding gene	Chr2:87907920-87918994 (-)
CBA/J	ENSMUSG00210030697	protein coding gene	Chr2:88678240-88689334 (-)
DBA/2J	ENSMUSG00185056570	protein coding gene	Chr2:88403758-88414843 (-)
FVB/NJ	ENSMUSG00205048824	protein coding gene	Chr2:87690444-87701590 (-)
JF1/MsJ	ENSUMUG00000014575	protein coding gene	Chr2:88219272-88230478 (-)
LP/J	ENSMUSG00230037676	protein coding gene	Chr2:90154416-90165505 (-)
NOD/ShiLtJ	ENSMUSG00190048468	protein coding gene	Chr2:88482512-88493597 (-)
NZO/HlLtJ	ENSMUSG00225050244	protein coding gene	Chr2:98069835-98080975 (-)
PWK/PhJ	ENSLUMG00010049501	protein coding gene	Chr2:88201057-88212191 (-)
SPRET/EiJ	ENSMSPG00010052075	protein coding gene	Chr2:90157725-90170041 (-)
WSB/EiJ	ENSIUOG00005053281	protein coding gene	Chr2:88207185-88218353 (-)

Human Ortholog

F2, coagulation factor II, thrombin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F2, coagulation factor II, thrombin
Synonyms

PT, RPRGL2, THPH1
Links

HGNC:3535

NCBI Gene ID: 2147

UniProt: P00734
Chr Location

11p11.2; chr11:46719166-46739822 (+) GRCh38

MGI Vertebrate Homology

F2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: F2
Protein SuperFamily

Thrombin
Gene Tree

F2

Diseases

23 with human F2 associations

				Human Disease	Mouse Models
				appendicitis IDs appendicitis DOID:8337 DOID:10275 DOID:10276 DOID:10947 ICD10CM:K37 ICD9CM:540-543.99 ICD9CM:541 MESH:D001064 NCI:C35145 UMLS_CUI:C0003615
				autoimmune hepatitis IDs autoimmune hepatitis DOID:2048 DOID:4745 ICD9CM:571.42 MESH:D019693 NCI:C27778 UMLS_CUI:C0241910 UMLS_CUI:C1332355
				carotid stenosis IDs carotid stenosis DOID:13001 MESH:D016893 NCI:C95804 UMLS_CUI:C0007282
				celiac disease IDs celiac disease DOID:10608 EFO:0001060 ICD10CM:K90.0 ICD9CM:579.0 MESH:D002446 NCI:C26714 OMIM:607202 OMIM:609754 OMIM:611598 OMIM:612005 OMIM:612006 OMIM:612007 OMIM:612008 OMIM:612009 OMIM:612011 ORDO:555 UMLS_CUI:C0007570
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				dengue disease IDs dengue disease DOID:12205 DOID:0050142 ICD10CM:A90 ICD9CM:061 MESH:D003715 NCI:C34528 UMLS_CUI:C0011311
				eye disease IDs eye disease DOID:5614 DOID:2933 ICD10CM:H44 ICD9CM:360 ICD9CM:360.9 ICD9CM:379.90 MESH:D005128 NCI:C26767 UMLS_CUI:C0015397
				factor VIII deficiency IDs factor VIII deficiency DOID:12134 ICD10CM:D66 ICD9CM_2006:286.0 ICD9CM:286.0 MESH:D006467 NCI:C27146 OMIM:306700 ORDO:98878 UMLS_CUI:C0019069
				glomerulonephritis IDs glomerulonephritis DOID:2921 ICD10CM:N08 MESH:D005921 NCI:C26784 UMLS_CUI:C0017658
				hemophilia B IDs hemophilia B DOID:12259 ICD10CM:D67 ICD9CM_2006:286.1 ICD9CM:286.1 MESH:D002836 NCI:C26721 OMIM:306900 UMLS_CUI:C0008533
				herpes zoster IDs herpes zoster DOID:8536 DOID:8554 DOID:8555 DOID:8772 DOID:8801 DOID:9085 ICD10CM:B02 ICD9CM:053 MESH:D006562 NCI:C71079 UMLS_CUI:C0019360
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				osteonecrosis IDs osteonecrosis DOID:10159 DOID:10160 DOID:10161 DOID:10162 DOID:10163 DOID:10164 DOID:4128 DOID:8380 DOID:86 ICD10CM:M87 ICD10CM:M87.9 ICD9CM:732.3 ICD9CM:733.41 ICD9CM:733.42 ICD9CM:733.43 ICD9CM:733.44 ICD9CM:733.49 MESH:D010020 NCI:C34404 NCI:C34841 NCI:C34880 NCI:C35226 NCI:C35517 UMLS_CUI:C0003977 UMLS_CUI:C0027543 UMLS_CUI:C0029445 UMLS_CUI:C0158442 UMLS_CUI:C0158449 UMLS_CUI:C0158450 UMLS_CUI:C0158451 UMLS_CUI:C0745048
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 ORDO:275555 UMLS_CUI:C0032914
				prothrombin deficiency IDs prothrombin deficiency DOID:2235 MESH:C562724 NCI:C26799 OMIM:613679 ORDO:325 UMLS_CUI:C0272317
				pulmonary embolism IDs pulmonary embolism DOID:9477 ICD10CM:I26 MESH:D011655 NCI:C50713 UMLS_CUI:C0034065
				retinal vein occlusion IDs retinal vein occlusion DOID:1727 MESH:D012170 NCI:C34981 UMLS_CUI:C0035328
				sensorineural hearing loss IDs sensorineural hearing loss DOID:10003 DOID:11053 DOID:12112 DOID:12114 ICD10CM:H90.5 ICD9CM_2006:389.11 ICD9CM_2006:389.14 ICD9CM:389.1 ICD9CM:389.10 ICD9CM:389.14 MESH:D006319 NCI:C26739 UMLS_CUI:C0018784
				stroke IDs stroke DOID:0051061
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				thrombophilia due to thrombin defect IDs thrombophilia due to thrombin defect DOID:0111907 OMIM:188050 UMLS_CUI:C3160733
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

38 phenotypes from 4 alleles in 6 genetic backgrounds
18 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Radiation induced

1
Targeted

11
Genomic Mutations

5 involving F2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit defects in yolk sac vasculature, internal bleeding, tissue necrosis, and die in mid- to late-gestation, or rarely, a few days after birth.

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All GO Annotations

85
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

37
cDNA Data

98
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA F2

Xenbase f2

ZFIN f2

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All Sequences

42
RefSeq

6
UniProt

3
CCDS

CCDS16434.1

Ensembl

ENSMUSG00000027249 (Evidence)
NCBI Gene

14061

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027249	Ensembl Gene Model \| MGI Sequence Detail	11095	C57BL/6J	± kb
transcript	ENSMUST00000028681	Ensembl \| MGI Sequence Detail	1988	Not Applicable
polypeptide	ENSMUSP00000028681	Ensembl \| MGI Sequence Detail	618	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007299 prothrombin

(term hierarchy)
PDB

2OCV, 2PUX, 2PV9, 3EDX, 3HK3, 3HK6, 3HKI
EC

3.4.21.5
InterPro Domains

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain

IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

IPR000001 Kringle

IPR018056 Kringle, conserved site

IPR013806 Kringle-like fold

IPR038178 Kringle superfamily

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR003966 Prothrombin/thrombin

IPR018114 Serine protease-like, trypsin family, histidine active site

IPR051659 Serine Protease S1 Domain-Containing Protein

IPR001254 Serine proteases, trypsin domain

IPR033116 Serine proteases, trypsin family, serine active site

IPR018992 Thrombin light chain

IPR037111 Thrombin light chain domain superfamily
GlyGen

P19221 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 108

Genomic 4

cDNA 98

Primer pair 4

Other 2

Antibodies 3

Microarray probesets 3

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MGD-MRK-1946, MGD-MRK-1952

Summaries

All 108

Developmental Gene Expression 15

Gene Ontology 14

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for F2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25197	Chr2:91466804-91466807 (-)	-47 bp
Tssr25196	Chr2:91466739-91466784 (-)	-3 bp
Tssr25195	Chr2:91466253-91466280 (-)	492 bp
Tssr25194	Chr2:91466225-91466249 (-)	522 bp
Tssr25193	Chr2:91466195-91466207 (-)	558 bp
Tssr25192	Chr2:91466147-91466157 (-)	607 bp
Tssr25191	Chr2:91461025-91461039 (-)	5,727 bp
Tssr25190	Chr2:91460908-91460919 (-)	5,845 bp
Tssr25189	Chr2:91459610-91459621 (-)	7,143 bp
Tssr25188	Chr2:91459586-91459595 (-)	7,168 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24