F2
Gene Detail

Symbol Name ID

F2 coagulation factor II MGI:88380

Synonyms

Cf2, Cf-2, FII, prothrombin, thrombin

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:91625329-91636407 bp, - strand From VEGA annotation of GRCm38   11079 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thrombin
Gene Tree: F2

Human homologs

Human Homolog		F2, coagulation factor II (thrombin)
NCBI Gene ID		2147
neXtProt AC		NX_P00734
Human Synonyms		PT, RPRGL2, THPH1
Human Chr (Location)		11p11; chr11:46740743-46761056 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human F2

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Homozygotes for targeted null mutations exhibit defects in yolk sac vasculature, internal bleeding, tissue necrosis, and die in mid- to late-gestation, or rarely, a few days after birth.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	acute-phase response, blood coagulation, ...
Component	extracellular region, extracellular space
Function	calcium ion binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (15)    Images (24)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	24
RT-PCR	22

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(103) Genomic(4) cDNA(97) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014282 (Evidence)
Ensembl Gene Model	ENSMUSG00000027249 (Evidence)
Entrez Gene	14061 (Evidence)
UniGene	89048
DFCI	TC1577552, TC1605052
DoTS	DT.60118651, DT.94208463
NIA Mouse Gene Index	U023025
EC	3.4.21.5
PDB	2OCV, 2PUX, 3EDX, 3HKI, 2PV9, 3HK3, 3HK6
Consensus CDS Project	CCDS16434.1
International Mouse Knockout Project Status	F2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014282	VEGA Gene Model | MGI Sequence Detail	11079	C57BL/6J
transcript	OTTMUST00000033633	VEGA | MGI Sequence Detail	1969	Not Applicable
polypeptide	OTTMUSP00000015068	VEGA | MGI Sequence Detail	617	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(163 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017857	Coagulation factor, subgroup, Gla domain
InterPro	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR003966	Peptidase S1A, prothrombin/thrombin
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR018992	Thrombin light chain
Protein Ontology	PR:000007299	prothrombin

References

(Earliest) J:10794 Degen SJ, et al., Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. DNA Cell Biol. 1990 Sep;9(7):487-98
(Latest) J:194757 Flick MJ, et al., Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood. 2013 Mar 7;121(10):1783-94
All references(57)

Other accession IDs

MGD-MRK-1946, MGD-MRK-1952