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F2
Gene Detail
Symbol

Name
ID
F2
coagulation factor II
MGI:88380
Synonyms
Cf2, Cf-2, FII, prothrombin, thrombin
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:91625329-91636407 bp, - strand
From VEGA annotation of GRCm38

  11079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: F2
Protein SuperFamily: thrombin
Gene Tree: F2

Human
homologs
F2, coagulation factor II (thrombin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2147
neXtProt AC: NX_P00734

Human Synonyms: PT, RPRGL2, THPH1

Human Chr (Location): 11p11; chr11:46719192-46739506 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human F2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(3) Targeted(10)
Genomic Mutations involving F2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects in yolk sac vasculature, internal bleeding, tissue necrosis, and die in mid- to late-gestation, or rarely, a few days after birth.
 
Interactions
F2 interacts with 28 markers (Mir29b-2, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process acute-phase response, blood coagulation, ...
Component blood microparticle, cytosol, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (50)    Tissues (17)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 22
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase f2 ; ZFIN f2    NEW 
Molecular
reagents
All nucleic(104) Genomic(4) cDNA(97) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014282 (Evidence)
Ensembl Gene Model ENSMUSG00000027249 (Evidence)
Entrez Gene 14061 (Evidence)
UniGene 89048
DFCI TC1577552, TC1605052
DoTS DT.60118651, DT.94208463
NIA Mouse Gene Index U023025
EC 3.4.21.5
PDB 2OCV, 2PUX, 2PV9, 3EDX, 3HK3, 3HK6, 3HKI
Consensus CDS Project CCDS16434.1
International Mouse Phenotyping Consortium Status F2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014282 VEGA Gene Model | MGI Sequence Detail 11079 C57BL/6J ±  kb
transcript OTTMUST00000033633 VEGA | MGI Sequence Detail 1969 Not Applicable 
polypeptide OTTMUSP00000015068 VEGA | MGI Sequence Detail 617 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR003966 Prothrombin/thrombin
InterPro IPR018992 Thrombin light chain
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007299 prothrombin
References
(Earliest) J:10794 Degen SJ, et al., Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. DNA Cell Biol. 1990 Sep;9(7):487-98
(Latest) J:212460 Turpin B, et al., Thrombin drives tumorigenesis in colitis-associated colon cancer. Cancer Res. 2014 Jun 1;74(11):3020-30
All references(59)
Other
accession IDs
MGD-MRK-1946, MGD-MRK-1952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory