Gene Expression Literature Summary

• Symbol: F2
• Name: coagulation factor II
• ID: MGI:88380

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)																		1			1
In situ RNA (section)				2	1		1		1	1		2				1
In situ reporter (knock in)																					1
Northern blot																					1
Western blot																				1	2
RT-PCR	1	1	1	1	2	1	1	2	1	1	1	3	2	1	2	1	1		2	1	7
cDNA clones			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

F2  coagulation factor II   (Synonyms: Cf2, Cf-2, FII, prothrombin, thrombin)
Results	Reference
1*	J:293506 Cao H, Cao B, Heazlewood CK, Domingues M, Sun X, Debele E, McGregor NE, Sims NA, Heazlewood SY, Nilsson SK, Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche. Cells. 2019 Aug 27;8(9):985
4*	J:54757 Citron BA, Smirnova IV, Zoubine MN, Festoff BW, Quantitative PCR analysis reveals novel expression of prothrombin mRNA and regulation of its levels in developing mouse muscle. Thromb Res. 1997 Aug 1;87(3):303-13
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:139818 Feutz AC, Barrandon Y, Monard D, Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells. J Cell Sci. 2008 May 1;121(Pt 9):1435-43
4	J:273795 Gould TW, Dominguez B, de Winter F, Yeo GW, Liu P, Sundararaman B, Stark T, Vu A, Degen JL, Lin W, Lee KF, Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal. PLoS Genet. 2019 Mar;15(3):e1007948
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
6*	J:262230 Lacombe J, Rishavy MA, Berkner KL, Ferron M, VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. JCI Insight. 2018 Jan 11;3(1)
2	J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733
5*	J:92354 Mesli S, Javorschi S, Berard AM, Landry M, Priddle H, Kivlichan D, Smith AJ, Yen FT, Bihain BE, Darmon M, Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation. Eur J Biochem. 2004 Aug;271(15):3103-14
9*	J:74089 Ong K, Horsfall W, Conway EM, Schuh AC, Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
6*	J:16414 Soifer SJ, Peters KG, O'Keefe J, Coughlin SR, Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan;144(1):60-9
4*	J:48273 Sun WY, Witte DP, Degen JL, Colbert MC, Burkart MC, Holmback K, Xiao Q, Bugge TH, Degen SJ, Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7597-602
1	J:152846 Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH, Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development. 2009 Aug;136(15):2653-63
5	J:36482 Zoubine MN, Ma JY, Smirnova IV, Citron BA, Festoff BW, A molecular mechanism for synapse elimination: novel inhibition of locally generated thrombin delays synapse loss in neonatal mouse muscle. Dev Biol. 1996 Nov 1;179(2):447-57