About   Help   FAQ
Cdk4 Gene Detail
Summary
  • Symbol
    Cdk4
  • Name
    cyclin-dependent kinase 4
  • Synonyms
    Crk3, p34PSK-J3/cdk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88357
    NCBI Gene: 12567
  • Gene Overview
    MyGene.info: CDK4
Location & Maps
more
  • Sequence Map
    Chr10:127063534-127067920 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4387 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CDK4, cyclin dependent kinase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDK4, cyclin dependent kinase 4
    Orthology source: HomoloGene
  • Synonyms
    CMM3, PSK-J3
  • Links
    NCBI Gene ID: 1019
    neXtProt AC: NX_P11802

  • Chr Location
    12q14; chr12:57747727-57752447 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cdk4 mouse models; 1 with human CDK4 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
       Melanoma, Cutaneous Malignant, Susceptibility to, 3; CMM3   OMIM: 609048 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 5 alleles in 5 genetic backgrounds
    68 phenotypes from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    106
  • Chemically induced (ENU)
    1
  • Gene trapped
    92
  • Targeted
    11
  • Transgenic
    2
  • Incidental Mutations
Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030604 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
transcript OTTMUST00000075793 VEGA | MGI Sequence Detail 2053 Not Applicable  
polypeptide OTTMUSP00000039796 VEGA | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 394
    cDNA 392
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1884, MGD-MRK-2147, MGI:88504
References
more
  • Summaries
    All 226
    Developmental Gene Expression 81
    Diseases 5
    Gene Ontology 31
    Phenotypes 85
  • Earliest
    J:2804 Matsushime H, et al., Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992 Oct 16;71(2):323-34
  • Latest
    J:231817 Matsumoto S, et al., Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory