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Cdk4
Gene Detail
 Symbol
Name
ID
Cdk4
cyclin-dependent kinase 4
MGI:88357
Synonyms Crk3, p34PSK-J3/cdk4
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:127063534-127067920 bp, + strand
From VEGA annotation of GRCm38

  4387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk4

Human
homologs
Human Homolog CDK4, cyclin-dependent kinase 4
NCBI Gene ID 1019
neXtProt AC  NX_P11802
Human Synonyms  CMM3, PSK-J3
Human Chr (Location)  12q14; chr12:57747727-57752447 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDK4
Mutations,
alleles, and
phenotypes
All mutations/alleles(101) : Chemically induced (ENU)(1) Gene trapped(92) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.
 
Human Diseases Modeled Using Mouse Cdk4 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cdk4 interacts with 126 markers (Mir16-1, Mir18, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process cell cycle, cell division, ...
Component chromatin, cyclin-dependent protein kinase holoenzyme complex, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (69 records)
Data Summary: Results (289)    Tissues (192)    Images (57)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 212
Northern blot 38
Western blot 39
cDNA source data(390)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(394) cDNA(392) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030604 (Evidence)
Ensembl Gene ModelENSMUSG00000006728 (Evidence)
Entrez Gene12567 (Evidence)
UniGene6839
DFCITC1573184
NIA Mouse Gene IndexU012134
EC2.7.11.22
Consensus CDS ProjectCCDS24226.1
International Mouse Knockout Project StatusCdk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030604 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
transcript OTTMUST00000075793 VEGA | MGI Sequence Detail 2053 Not Applicable 
polypeptide OTTMUSP00000039796 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(10)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005257 cell division protein kinase 4
References (Earliest) J:2804 Matsushime H, et al., Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992 Oct 16;71(2):323-34
(Latest) J:209613 Lu Y, et al., CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. J Clin Invest. 2014 Apr 1;124(4):1672-84
All references(203)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1884, MGD-MRK-2147, MGI:88504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory