About   Help   FAQ
Cdk4
Gene Detail
Symbol

Name
ID
Cdk4
cyclin-dependent kinase 4
MGI:88357
Synonyms
Crk3, p34PSK-J3/cdk4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:127063534-127067920 bp, + strand
From VEGA annotation of GRCm38

  4387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK4
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk4

Human
homologs
CDK4, cyclin-dependent kinase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1019
neXtProt AC: NX_P11802

Human Synonyms: CMM3, PSK-J3

Human Chr (Location): 12q14; chr12:57747727-57752447 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDK4

Mutations,
alleles, and
phenotypes
All mutations/alleles(101) : Chemically induced (ENU)(1) Gene trapped(92) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.
 
Human Diseases Modeled in Mice Using Cdk4 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Cdk4 interacts with 126 markers (Mir16-1, Mir18, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process cell cycle, cell division, ...
Component bicellular tight junction, chromatin, ...
Function ATP binding, cyclin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (289)    Tissues (197)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 212
Northern blot 38
Western blot 39
cDNA source data(390)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk4    NEW 
Molecular
reagents
All nucleic(394) cDNA(392) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030604 (Evidence)
Ensembl Gene Model ENSMUSG00000006728 (Evidence)
Entrez Gene 12567 (Evidence)
UniGene 6839
DFCI TC1573184
NIA Mouse Gene Index U012134
EC 2.7.11.22
Consensus CDS Project CCDS24226.1
International Mouse Phenotyping Consortium Status Cdk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030604 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
transcript OTTMUST00000075793 VEGA | MGI Sequence Detail 2053 Not Applicable 
polypeptide OTTMUSP00000039796 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(10)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005257 cell division protein kinase 4
References
(Earliest) J:2804 Matsushime H, et al., Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992 Oct 16;71(2):323-34
(Latest) J:222533 Ferguson B, et al., Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression. Oncogene. 2015 May 28;34(22):2879-86
All references(215)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1884, MGD-MRK-2147, MGI:88504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory