Cdk4
Gene Detail

Symbol Name ID

Cdk4 cyclin-dependent kinase 4 MGI:88357

Synonyms

Crk3, p34/cdk4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.50 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:127063534-127067920 bp, + strand From VEGA annotation of GRCm38   4387 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55429  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk4

Human homologs

Human Homolog		CDK4, cyclin-dependent kinase 4
NCBI Gene ID		1019
neXtProt AC		NX_P11802
Human Synonyms		CMM3, PSK-J3
Human Chr (Location)		12q14; chr12:58141510-58146230 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDK4

Alleles and phenotypes

All alleles(100) : Targeted(7) Gene trapped(92) Chemically induced(1)
 

Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles.

 
Human Diseases Modeled Using Mouse Cdk4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	cell cycle, cell division, ...
Component	chromatin, cyclin-dependent protein kinase holoenzyme complex, ...
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (63 records)
Data Summary: Results (267)    Tissues (171)    Images (55)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	190
Northern blot	38
Western blot	39

cDNA source data(389)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(393) cDNA(391) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030604 (Evidence)
Ensembl Gene Model	ENSMUSG00000006728 (Evidence)
Entrez Gene	12567 (Evidence)
UniGene	6839
DFCI	TC1573184
NIA Mouse Gene Index	U012134
EC	2.7.11.22
Consensus CDS Project	CCDS24226.1
International Mouse Knockout Project Status	Cdk4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030604	VEGA Gene Model | MGI Sequence Detail	4387	C57BL/6J
transcript	OTTMUST00000075793	VEGA | MGI Sequence Detail	2053	Not Applicable
polypeptide	OTTMUSP00000039796	VEGA | MGI Sequence Detail	303	Not Applicable

All sequences(68) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005257	cell division protein kinase 4

References

(Earliest) J:2804 Matsushime H, et al., Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992 Oct 16;71(2):323-34
(Latest) J:194573 Lim S, et al., Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells. 2012 Jul;30(7):1509-20
All references(186)

Other accession IDs

MGD-MRK-1884, MGD-MRK-2147, MGI:88504