Cdk4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk4
cyclin dependent kinase 4
MGI:88357

56 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk4^tm1.1Bbd/Cdk4⁺ involves: 129S1/Sv * 129X1/SvJ * ICR	increased pancreatic beta cell number	J:54534
Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd B6.129(Cg)-Cdk4^tm1.1Bbd	normal neoplasm	J:111992
Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR	normal homeostasis/metabolism phenotype	J:54534
	increased body weight	J:54534
	increased Leydig cell number	J:54534
	increased pancreatic beta cell number	J:54534
Cdk4^{tm1b(NCOM)Mfgc}/Cdk4⁺ C57BL/6N-Cdk4^{tm1b(NCOM)Mfgc}/Tcp	abnormal cranium morphology	J:211773
	decreased body length	J:211773
	increased mean corpuscular volume	J:211773
Cdk4^{tm1b(NCOM)Mfgc}/Cdk4^{tm1b(NCOM)Mfgc} C57BL/6N-Cdk4^{tm1b(NCOM)Mfgc}/Tcp	abnormal embryo size	J:211773
	edema	J:211773
	female infertility	J:211773
	male infertility	J:211773
	microphthalmia	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Cdk4^tm1Bbd/Cdk4^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR	abnormal cell cycle	J:54534
	abnormal corpus luteum morphology	J:54534
	abnormal female reproductive system morphology	J:54534
	abnormal female reproductive system physiology	J:54534
	abnormal locomotor behavior	J:54534
	abnormal male reproductive system morphology	J:54534
	abnormal male reproductive system physiology	J:54534
	abnormal pancreatic islet morphology	J:54534
	abnormal seminiferous tubule morphology	J:54534
	abnormal Sertoli cell morphology	J:54534
	decreased body size	J:54534
	decreased body weight	J:54534
	decreased circulating follicle stimulating hormone level	J:54534
	decreased circulating insulin level	J:54534
	decreased circulating progesterone level	J:54534
	decreased Leydig cell number	J:54534
	decreased testis weight	J:54534
	delayed estrus	J:54534
	female infertility	J:54534
	hyperactivity	J:54534
	hyperglycemia	J:54534
	impaired limb coordination	J:54534
	increased urine glucose level	J:54534
	ketoaciduria	J:54534
	oligozoospermia	J:54534
	polydipsia	J:54534
	polyuria	J:54534
	postnatal lethality	J:54534
	reduced male fertility	J:54534
	small ovary	J:54534
	small pancreatic islets	J:54534
Cdk4^tm1Kiyo/Cdk4^tm1Kiyo involves: 129S1/Sv	absent Leydig cells	J:111333
	adenohypophysis hypoplasia	J:111333
	azoospermia	J:111333
	decreased body weight	J:111333
	decreased lactotroph cell number	J:111333
	female infertility	J:111333
	male infertility	J:111333
Cdk4^tm1Kiyo/Cdk4^tm1Kiyo involves: 129S1/Sv * C57BL/6	abnormal corpus luteum morphology	J:57854
	abnormal female reproductive system morphology	J:57854
	abnormal fertility/fecundity	J:57854
	abnormal male reproductive system morphology	J:57854
	abnormal pancreatic islet morphology	J:57854
	abnormal testis morphology	J:57854
	decreased body size	J:57854
	female infertility	J:57854
	impaired luteinization	J:57854
	increased urine glucose level	J:57854
	oligozoospermia	J:57854
	postnatal lethality, incomplete penetrance	J:57854
	reduced male fertility	J:57854
	small seminiferous tubules	J:57854
	small testis	J:57854
Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 * SJL	no abnormal phenotype detected	J:82809
Cdk4^wnch/Cdk4^wnch C57BL/6JAnu-Cdk4^wnch	abnormal glucose homeostasis	J:104190

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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