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Cdh1
Gene Detail
Symbol

Name
ID
Cdh1
cadherin 1
MGI:88354
Synonyms
Ecad, E-cad, E-cadherin, L-CAM, UM, uvomorulin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.18 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr8:106603351-106670246 bp, + strand
From VEGA annotation of GRCm38

  66896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh1

Human
homologs
Human Homolog CDH1, cadherin 1, type 1, E-cadherin (epithelial)
NCBI Gene ID 999
neXtProt AC  NX_P12830
Human Synonyms  Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Human Chr (Location)  16q22.1; chr16:68737292-68835541 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human CDH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(463) : Gene trapped(446) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
 
Phenotype Images(2)
Interactions
Cdh1 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (693 records)
Data Summary: Results (1138)    Tissues (597)    Images (336)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 366
RNA in situ 571
Northern blot 10
Western blot 35
RT-PCR 156
cDNA source data(281)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(308) Genomic(9) cDNA(283) Primer pair(14) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020588 (Evidence)
Ensembl Gene ModelENSMUSG00000000303 (Evidence)
Entrez Gene12550 (Evidence)
UniGene35605
DFCITC1573477
DoTSDT.495106, DT.101379338, DT.110879882
NIA Mouse Gene IndexU009777
PDB1EDH, 1I7W, 1I7X, 1Q1P, 1SUH, 2OMW, 2QVF, 3IFQ, 3LNE, 3LNF, 3LNG, 3LNH, 3LNI, 3Q2L, 3Q2N, 3Q2V, 3QRB, 1FF5, 4QD2
Consensus CDS ProjectCCDS22638.1
International Mouse Knockout Project StatusCdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020588 VEGA Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
transcript OTTMUST00000048788 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000022465 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(412 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001447 cadherin-1
References
(Earliest) J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
(Latest) J:213958 Lang RA, et al., p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis. Development. 2014 Aug;141(16):3177-87
All references(906)
Other
accession IDs
MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory