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Cdh1
Gene Detail
Symbol

Name
ID
Cdh1
cadherin 1
MGI:88354
Synonyms
Ecad, E-cad, E-cadherin, L-CAM, UM, uvomorulin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.18 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr8:106603351-106670246 bp, + strand
From VEGA annotation of GRCm38

  66896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

HCOP human homology predictions: CDH1
Protein SuperFamily: cadherin
Gene Tree: Cdh1

Human
homologs
CDH1, cadherin 1, type 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 999
neXtProt AC: NX_P12830

Human Synonyms: Arc-1, CD324, CDHE, ECAD, LCAM, UVO

Human Chr (Location): 16q22.1; chr16:68737292-68835542 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human CDH1

Mutations,
alleles, and
phenotypes
All mutations/alleles(463) : Gene trapped(446) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Cdh1 interacts with 215 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (102 annotations)
Process adherens junction organization, bicellular tight junction assembly, ...
Component actin cytoskeleton, adherens junction, ...
Function ankyrin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (756 records)
Data Summary: Results (1211)    Tissues (639)    Images (366)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 437
RNA in situ 573
Northern blot 10
Western blot 35
RT-PCR 156
cDNA source data(281)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CDH1 ; Xenbase cdh1 ; ZFIN cdh1    NEW 
Molecular
reagents
All nucleic(309) Genomic(9) cDNA(283) Primer pair(14) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020588 (Evidence)
Ensembl Gene Model ENSMUSG00000000303 (Evidence)
Entrez Gene 12550 (Evidence)
UniGene 35605
DFCI TC1573477
DoTS DT.101379338, DT.110879882, DT.495106
NIA Mouse Gene Index U009777
PDB 1EDH, 1I7W, 1I7X, 1Q1P, 1SUH, 2OMW, 2QVF, 3IFQ, 3LNE, 3LNF, 3LNG, 3LNH, 3LNI, 3Q2L, 3Q2N, 3Q2V, 3QRB, 1FF5, 4QD2
Consensus CDS Project CCDS22638.1
International Mouse Phenotyping Consortium Status Cdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020588 VEGA Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
transcript OTTMUST00000048788 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000022465 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(5) : SNPs within 2kb(412 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001447 cadherin-1
References
(Earliest) J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
(Latest) J:222248 Fossat N, et al., Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
All references(972)
Other
accession IDs
MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory