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Cdh1 Gene Detail
Summary
  • Symbol
    Cdh1
  • Name
    cadherin 1
  • Synonyms
    Ecad, E-cad, E-cadherin, L-CAM, UM, uvomorulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88354
    NCBI Gene: 12550
  • Gene Overview
    MyGene.info: CDH1
Location & Maps
more
  • Sequence Map
    Chr8:106603351-106670246 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66896 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.18 cM, cytoband D
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    CDH1, cadherin 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CDH1, cadherin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Arc-1, CD324, CDHE, ECAD, LCAM, UVO
  • Links
    NCBI Gene ID: 999
    neXtProt AC: NX_P12830

  • Chr Location
    16q22.1; chr16:68737292-68835542 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20917
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;5 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CDH1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    5 with human CDH1 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Endometrial Cancer   OMIM: 608089
Gastric Cancer, Hereditary Diffuse; HDGC   OMIM: 137215 View 1 model
Ovarian Cancer   OMIM: 167000
Prostate Cancer   OMIM: 176807
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 14 alleles in 10 genetic backgrounds
    28 phenotypes from multigenic genotypes
    2 images
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020588 VEGA Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
transcript OTTMUST00000048788 VEGA | MGI Sequence Detail 4430 Not Applicable  
polypeptide OTTMUSP00000022465 VEGA | MGI Sequence Detail 884 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    408 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 314
    Genomic 9
    cDNA 285
    Primer pair 14
    Other 6

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457
References
more
  • Summaries
    All 1050
    Developmental Gene Expression 828
    Diseases 1
    Gene Ontology 89
    Phenotypes 80
  • Earliest
    J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
  • Latest
    J:234178 Perdigoto CN, et al., Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016 Jul;12(7):e1006151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory