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Gene Detail
cadherin 1
Synonyms Ecad, E-cad, E-cadherin, L-CAM, UM, uvomorulin
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.18 cM, cytoband D
Detailed Genetic Map ± 1 cM

Mapping data(21)
Sequence Map
Chr8:106603351-106670246 bp, + strand
From VEGA annotation of GRCm38

  66896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh1

Human Homolog CDH1, cadherin 1, type 1, E-cadherin (epithelial)
NCBI Gene ID 999
neXtProt AC  NX_P12830
Human Synonyms  Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Human Chr (Location)  16q22.1; chr16:68737292-68835541 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human CDH1
alleles, and
All mutations/alleles(463) : Gene trapped(446) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
Phenotype Images(2)
Cdh1 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (97 annotations)
Process adherens junction organization, calcium-dependent cell-cell adhesion, ...
Component actin cytoskeleton, adherens junction, ...
Function ankyrin binding, beta-catenin binding, ...
External Resources: FuncBase
Literature Summary: (675 records)
Data Summary: Results (1137)    Tissues (598)    Images (334)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 365
RNA in situ 572
Northern blot 10
Western blot 35
RT-PCR 155
cDNA source data(281)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(307) Genomic(9) cDNA(283) Primer pair(13) Other(2)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000020588 (Evidence)
Ensembl Gene ModelENSMUSG00000000303 (Evidence)
Entrez Gene12550 (Evidence)
DoTSDT.495106, DT.101379338, DT.110879882
NIA Mouse Gene IndexU009777
PDB1EDH, 1I7W, 1I7X, 1Q1P, 1SUH, 2OMW, 2QVF, 3IFQ, 3LNE, 3LNF, 3LNG, 3LNH, 3LNI, 3Q2L, 3Q2N, 3Q2V, 3QRB, 1FF5
Consensus CDS ProjectCCDS22638.1
International Mouse Knockout Project StatusCdh1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020588 VEGA Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
transcript OTTMUST00000048788 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000022465 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(412 from dbSNP Build 137)
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001447 cadherin-1
References (Earliest) J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
(Latest) J:209623 Kurosaka H, et al., Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest. 2014 Apr 1;124(4):1660-71
All references(884)
accession IDs
MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory