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Cdh1
Gene Detail
 Symbol
Name
ID
Cdh1
cadherin 1
MGI:88354
Synonyms Ecad, E-cad, E-cadherin, L-CAM, UM, uvomorulin
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.18 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr8:106603351-106670246 bp, + strand
From VEGA annotation of GRCm38

  66896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cadherin
Gene Tree: Cdh1

Human
homologs
Human Homolog CDH1, cadherin 1, type 1, E-cadherin (epithelial)
NCBI Gene ID 999
neXtProt AC  NX_P12830
Human Synonyms  Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Human Chr (Location)  16q22.1; chr16:68737292-68835541 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human CDH1
Alleles
and
phenotypes
All alleles(463) : Targeted(17) Gene trapped(446)
 
In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (91 annotations)
Process cell adhesion, cell-cell adhesion, ...
Component actin cytoskeleton, adherens junction, ...
Function ankyrin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (662 records)
Data Summary: Results (1105)    Tissues (577)    Images (294)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 324
RNA in situ 572
Northern blot 10
Western blot 39
RT-PCR 160
cDNA source data(281)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(307) Genomic(9) cDNA(283) Primer pair(13) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020588 (Evidence)
Ensembl Gene ModelENSMUSG00000000303 (Evidence)
Entrez Gene12550 (Evidence)
UniGene35605
DFCITC1573477
DoTSDT.495106, DT.101379338, DT.110879882
NIA Mouse Gene IndexU009777
PDB1EDH, 1I7W, 1I7X, 1Q1P, 1SUH, 2OMW, 2QVF, 3IFQ, 3LNE, 3LNF, 3LNG, 3LNH, 3LNI, 3Q2L, 3Q2N, 3Q2V, 3QRB, 1FF5
Consensus CDS ProjectCCDS22638.1
International Mouse Knockout Project StatusCdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020588 VEGA Gene Model | MGI Sequence Detail 66896 C57BL/6J ±  kb
transcript OTTMUST00000048788 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000022465 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(412 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
Protein Ontology PR:000001447 epithelial cadherin
References (Earliest) J:31272 Peyrieras N, et al., Uvomorulin: a nonintegral membrane protein of early mouse embryo. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6274-7
(Latest) J:206505 Nakagawa H, et al., Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5
All references(867)
Other
accession IDs
MGD-MRK-15349, MGD-MRK-1881, MGD-MRK-19360, MGI:2142457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory