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Cd69 Gene Detail
Summary
  • Symbol
    Cd69
  • Name
    CD69 antigen
  • Synonyms
    5830438K24Rik, AIM, VEA
  • Feature Type
    protein coding gene
  • IDs
    MGI:88343
    NCBI Gene: 12515
  • Gene Overview
    MyGene.info: CD69
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129267324-129275369 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.21 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88343
protein coding gene Chr6:129267324-129275436 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031342
protein coding gene Chr6:132928738-132936845 (-)
A/J MGP_AJ_G0031313
protein coding gene Chr6:127841281-127849394 (-)
AKR/J MGP_AKRJ_G0031241
protein coding gene Chr6:131335648-131343761 (-)
BALB/cJ MGP_BALBcJ_G0031320
protein coding gene Chr6:127490016-127498141 (-)
C3H/HeJ MGP_C3HHeJ_G0031044
protein coding gene Chr6:131521775-131529888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031779
protein coding gene Chr6:136419164-136427275 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028925
protein coding gene Chr6:125346817-125354969 (-)
CAST/EiJ MGP_CASTEiJ_G0030422
protein coding gene Chr6:131750019-131758499 (-)
CBA/J MGP_CBAJ_G0031004
protein coding gene Chr6:141776925-141785038 (-)
DBA/2J MGP_DBA2J_G0031161
protein coding gene Chr6:126793525-126801638 (-)
FVB/NJ MGP_FVBNJ_G0031111
protein coding gene Chr6:125674145-125682259 (-)
LP/J MGP_LPJ_G0031241
protein coding gene Chr6:133139673-133147849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031149
protein coding gene Chr6:145634149-145642259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031812
protein coding gene Chr6:131392670-131400915 (-)
PWK/PhJ MGP_PWKPhJ_G0030140
protein coding gene Chr6:125075778-125083894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029969
protein coding gene Chr6:129417551-129427754 (-)
WSB/EiJ MGP_WSBEiJ_G0030510
protein coding gene Chr6:131815268-131823469 (-)



Homology
more
  • Human Ortholog
    CD69, CD69 molecule
  • Vertebrate Orthologs
    30
  • Human Ortholog
    CD69, CD69 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
  • Links
    NCBI Gene ID: 969
    neXtProt AC: NX_Q07108
    UniProt: Q07108

  • Chr Location
    12p13.31; chr12:9752486-9760901 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in slightly increased pre-B and immature B cell numbers in the bone marrow, and increased IgG2a and IgM response to T cell-dependent and T cell-independent antigens. Mutant mice were less prone to collagen inducedarthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12515 NCBI Gene Model | MGI Sequence Detail 8046 C57BL/6J ±  kb
transcript NM_001033122 RefSeq | MGI Sequence Detail 1631 C57BL/6  
polypeptide P37217 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 9
    cDNA 22
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1869, MGI:1889838, MGI:1923299
References
more
  • Summaries
    All 105
    Gene Ontology 21
    Phenotypes 25
  • Earliest
    J:9232 Yokoyama WM, et al., Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol. 1988 Jul 15;141(2):369-76
  • Latest
    J:259300 Fang V, et al., Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-gamma response. Nat Immunol. 2017 Jan;18(1):15-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory