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Cd69 Gene Detail
Summary
  • Symbol
    Cd69
  • Name
    CD69 antigen
  • Synonyms
    5830438K24Rik, AIM, VEA
  • Feature Type
    protein coding gene
  • IDs
    MGI:88343
    NCBI Gene: 12515
  • Gene Overview
    MyGene.info: CD69
Location & Maps
more
  • Sequence Map
    Chr6:129267325-129275436 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8112 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.21 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    CD69, CD69 molecule
  • Vertebrate Orthologs
    30
  • Human Ortholog
    CD69, CD69 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
  • Links
    NCBI Gene ID: 969
    neXtProt AC: NX_Q07108

  • Chr Location
    12p13.31; chr12:9752486-9760901 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in slightly increased pre-B and immature B cell numbers in the bone marrow, and increased IgG2a and IgM response to T cell-dependent and T cell-independent antigens. Mutant mice were less prone to collagen inducedarthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056464 VEGA Gene Model | MGI Sequence Detail 8112 C57BL/6J ±  kb
transcript OTTMUST00000139475 VEGA | MGI Sequence Detail 1687 Not Applicable  
polypeptide OTTMUSP00000073172 VEGA | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 31
    Genomic 9
    cDNA 21
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1869, MGI:1889838, MGI:1923299
References
more
  • Summaries
    All 85
    Gene Ontology 19
    Phenotypes 20
  • Earliest
    J:9232 Yokoyama WM, et al., Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol. 1988 Jul 15;141(2):369-76
  • Latest
    J:234487 Notario L, et al., CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis. J Virol. 2016 Jul 15;90(14):6464-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory