About   Help   FAQ
Cd44
Gene Detail
 Symbol
Name
ID
Cd44
CD44 antigen
MGI:88338
Synonyms HERMES, Ly-24, Pgp-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
54.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr2:102811141-102901625 bp, - strand
From VEGA annotation of GRCm38

  90485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cd44

Human
homologs
Human Homolog CD44, CD44 molecule (Indian blood group)
NCBI Gene ID 960
neXtProt AC  NX_P16070
Human Synonyms  CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
Human Chr (Location)  11p13; chr11:35138870-35232402 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Genomic Mutations involving Cd44 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired T lymphocyte trafficking resulting in muted inflammatory responses, altered myeloid progenitor distribution, reduced growth of tumors, and impaired uterine involution and maintenance of lactation.
 
Interactions
Cd44 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process branching involved in prostate gland morphogenesis, branching involved in ureteric bud morphogenesis, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function cytokine binding, epidermal growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (380)    Tissues (290)    Images (64)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 101
RNA in situ 183
Western blot 18
RT-PCR 78
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(3) cDNA(41) Primer pair(9)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000014837 (Evidence)
Ensembl Gene ModelENSMUSG00000005087 (Evidence)
Entrez Gene12505 (Evidence)
DFCITC1572950, TC1588499, TC1591122, TC1592769, TC1596221, TC1608873, TC1609344, TC1660204, TC1678779, TC1696056, TC1712038
DoTSDT.101135238, DT.101400128, DT.101737541, DT.103563457, DT.110689371, DT.528375, DT.531143, DT.94130309, DT.94209211, DT.97360610, DT.97388952
NIA Mouse Gene IndexU069452, U091300
PDB2JCP, 2JCQ, 2JCR, 2ZPY, 4MRD, 4MRE, 4MRF, 4MRG, 4MRH, 4NP2, 4NP3
Consensus CDS ProjectCCDS16470.1, CCDS16471.1, CCDS16472.1, CCDS50648.1, CCDS50649.1, CCDS50650.1
International Mouse Knockout Project StatusCd44
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014837 VEGA Gene Model | MGI Sequence Detail 90485 C57BL/6J ±  kb
transcript OTTMUST00000035222 VEGA | MGI Sequence Detail 5614 Not Applicable 
polypeptide OTTMUSP00000015733 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(22) UniProt(12)
Polymorphisms SNPs within 2kb(782 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001231 CD44 antigen
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR000538 Link
Protein Ontology PR:000001307 CD44 molecule
References (Earliest) J:6734 Trowbridge IS, et al., Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics. 1982 Mar;15(3):299-312
(Latest) J:208688 Krause DS, et al., Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche. Blood. 2014 Feb 27;123(9):1361-71
All references(327)
Other
accession IDs
MGD-MRK-11964, MGD-MRK-13281, MGD-MRK-1863, MGI:2139311, MGI:2139322, MGI:3035411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory