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Cd44
Gene Detail
Symbol

Name
ID
Cd44
CD44 antigen
MGI:88338
Synonyms
HERMES, Ly-24, Pgp-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr2:102811141-102901625 bp, - strand
From VEGA annotation of GRCm38

  90485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cd44

Human
homologs
Human Homolog CD44, CD44 molecule (Indian blood group)
NCBI Gene ID 960
neXtProt AC  NX_P16070
Human Synonyms  CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
Human Chr (Location)  11p13; chr11:35138870-35232402 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Genomic Mutations involving Cd44 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired T lymphocyte trafficking resulting in muted inflammatory responses, altered myeloid progenitor distribution, reduced growth of tumors, and impaired uterine involution and maintenance of lactation.
 
Interactions
Cd44 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (61 records)
Data Summary: Results (380)    Tissues (290)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 101
RNA in situ 183
Western blot 18
RT-PCR 78
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(3) cDNA(41) Primer pair(9)
Microarray probesets(10)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014837 VEGA Gene Model | MGI Sequence Detail 90485 C57BL/6J ±  kb
transcript OTTMUST00000035222 VEGA | MGI Sequence Detail 5614 Not Applicable 
polypeptide OTTMUSP00000015733 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(138) RefSeq(22) UniProt(23)
Polymorphisms
SNPs within 2kb(782 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001231 CD44 antigen
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR000538 Link
Protein Ontology PR:000001307 CD44 molecule
References
(Earliest) J:6734 Trowbridge IS, et al., Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics. 1982 Mar;15(3):299-312
(Latest) J:213017 Tsuneki M, et al., CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression. J Biol Chem. 2014 Feb 28;289(9):5357-70
All references(330)
Other
accession IDs
MGD-MRK-11964, MGD-MRK-13281, MGD-MRK-1863, MGI:2139311, MGI:2139322, MGI:3035411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory