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Cd44 Gene Detail
Summary
  • Symbol
    Cd44
  • Name
    CD44 antigen
  • Synonyms
    HERMES, Ly-24, Pgp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88338
    NCBI Gene: 12505
  • Gene Overview
    MyGene.info: CD44
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:102811141-102901665 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.13 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    773 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88338
protein coding gene Chr2:102811141-102901669 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026199
protein coding gene Chr2:104741863-104846292 (-)
A/J MGP_AJ_G0026160
protein coding gene Chr2:100439949-100532666 (-)
AKR/J MGP_AKRJ_G0026141
protein coding gene Chr2:103151124-103244929 (-)
BALB/cJ MGP_BALBcJ_G0026169
protein coding gene Chr2:100714952-100809028 (-)
C3H/HeJ MGP_C3HHeJ_G0025920
protein coding gene Chr2:103521353-103613937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026620
protein coding gene Chr2:108266700-108386727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024011
protein coding gene Chr2:96114085-96203109 (-)
CAST/EiJ MGP_CASTEiJ_G0025385
protein coding gene Chr2:103962115-104055803 (-)
CBA/J MGP_CBAJ_G0025898
protein coding gene Chr2:111978219-112077284 (-)
DBA/2J MGP_DBA2J_G0026034
protein coding gene Chr2:100001378-100091791 (-)
FVB/NJ MGP_FVBNJ_G0025997
protein coding gene Chr2:99003704-99095656 (-)
LP/J MGP_LPJ_G0026138
protein coding gene Chr2:104890932-104987502 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026023
protein coding gene Chr2:115930542-116027717 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026674
protein coding gene Chr2:103371425-103465940 (-)
PWK/PhJ MGP_PWKPhJ_G0025120
protein coding gene Chr2:99500466-99592033 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024921
protein coding gene Chr2:102594268-102691052 (-)
WSB/EiJ MGP_WSBEiJ_G0025452
protein coding gene Chr2:104076025-104169657 (-)



Homology
more
  • Human Ortholog
    CD44, CD44 molecule (Indian blood group)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD44, CD44 molecule (Indian blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
  • Links
    NCBI Gene ID: 960
    neXtProt AC: NX_P16070
    UniProt: P16070

  • Chr Location
    11p13; chr11:35138870-35232402 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 508
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CD44
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 9 alleles in 15 genetic backgrounds
    47 phenotypes from multigenic genotypes
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired T lymphocyte trafficking resulting in muted inflammatory responses, altered myeloid progenitor distribution, reduced growth of tumors, and impaired uterine involution and maintenance of lactation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005087 Ensembl Gene Model | MGI Sequence Detail 90525 C57BL/6J ±  kb
    transcript ENSMUST00000005218 Ensembl | MGI Sequence Detail 5614 Not Applicable  
    polypeptide ENSMUSP00000005218 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 3
      cDNA 42
      Primer pair 28

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-11964, MGD-MRK-13281, MGD-MRK-1863, MGI:2139311, MGI:2139322, MGI:3035411
    References
    more
    • Summaries
      All 418
      Developmental Gene Expression 84
      Gene Ontology 51
      Phenotypes 165
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264782 Govindaraju P, et al., CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing. Matrix Biol. 2018 Jun 9;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory