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Cd44 Gene Detail
Summary
  • Symbol
    Cd44
  • Name
    CD44 antigen
  • Synonyms
    HERMES, Ly-24, Pgp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88338
    NCBI Gene: 12505
  • Gene Overview
    MyGene.info: CD44
Location & Maps
more
  • Sequence Map
    Chr2:102811141-102901625 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90485 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD44, CD44 molecule (Indian blood group)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD44, CD44 molecule (Indian blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
  • Links
    NCBI Gene ID: 960
    neXtProt AC: NX_P16070

  • Chr Location
    11p13; chr11:35138870-35232402 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 508
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: CD44
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    81 phenotypes from 9 alleles in 15 genetic backgrounds
    45 phenotypes from multigenic genotypes
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    13
  • Transgenic
    1
  • Genomic Mutations
    5 involving Cd44
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired T lymphocyte trafficking resulting in muted inflammatory responses, altered myeloid progenitor distribution, reduced growth of tumors, and impaired uterine involution and maintenance of lactation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014837 VEGA Gene Model | MGI Sequence Detail 90485 C57BL/6J ±  kb
transcript OTTMUST00000035222 VEGA | MGI Sequence Detail 5614 Not Applicable  
polypeptide OTTMUSP00000015733 VEGA | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    773 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 53
    Genomic 3
    cDNA 41
    Primer pair 9

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-11964, MGD-MRK-13281, MGD-MRK-1863, MGI:2139311, MGI:2139322, MGI:3035411
References
more
  • Summaries
    All 348
    Developmental Gene Expression 73
    Gene Ontology 46
    Phenotypes 144
  • Earliest
    J:6734 Trowbridge IS, et al., Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics. 1982 Mar;15(3):299-312
  • Latest
    J:228225 Parra LM, et al., Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44. Mol Cell Biol. 2015 Oct;35(19):3381-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory