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Cd4
Gene Detail
Symbol

Name
ID
Cd4
CD4 antigen
MGI:88335
STS
Synonyms
L3T4, Ly-4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr6:124864692-124888221 bp, - strand
From VEGA annotation of GRCm38

  23530 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CD4
Protein SuperFamily: T-cell surface glycoprotein CD4
Gene Tree: Cd4

Human
homologs
CD4, CD4 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 920
neXtProt AC: NX_P01730

Human Synonyms: CD4mut

Human Chr (Location): 12p13.31; chr12:6789472-6820810 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD4

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(5) Gene trapped(6) Spontaneous(2) Targeted(18) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.
 
Mutations Annotated to Human Diseases (3)   
Interactions
Cd4 interacts with 207 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process adaptive immune response, cell adhesion, ...
Component cell surface, endoplasmic reticulum lumen, ...
Function coreceptor activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (145)    Tissues (49)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RT-PCR 138
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cd4    NEW 
Molecular
reagents
All nucleic(53) Genomic(15) cDNA(34) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023420 (Evidence)
Ensembl Gene Model ENSMUSG00000023274 (Evidence)
Entrez Gene 12504 (Evidence)
UniGene 2209
DFCI TC1584295, TC1621323, TC1754381
DoTS DT.87068508, DT.91436625, DT.94130300
NIA Mouse Gene Index U027855
Consensus CDS Project CCDS20535.1
International Mouse Phenotyping Consortium Status Cd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023420 VEGA Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
transcript OTTMUST00000056904 VEGA | MGI Sequence Detail 3108 Not Applicable 
polypeptide OTTMUSP00000027399 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(4)
Polymorphisms
All PCR and RFLP(8) : PCR(6) RFLP(2) SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015274 CD4, extracellular
InterPro IPR013151 Immunoglobulin
InterPro IPR008424 Immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR021963 T cell CD4 receptor C-terminal region
InterPro IPR000973 T-cell surface antigen CD4
Protein Ontology PR:000001004 CD4 molecule
References
(Earliest) J:5358 Snell GD, et al., Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11
(Latest) J:221845 Laroumanie F, et al., CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload. Circulation. 2014 May 27;129(21):2111-24
All references(498)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11981, MGD-MRK-1858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory