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Cd4 Gene Detail
Summary
  • Symbol
    Cd4
  • Name
    CD4 antigen
  • Synonyms
    L3T4, Ly-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88335
    NCBI Gene: 12504
  • Gene Overview
    MyGene.info: CD4
Location & Maps
more
  • Sequence Map
    Chr6:124864692-124888221 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23530 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    26 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    CD4, CD4 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD4, CD4 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD4mut
  • Links
    NCBI Gene ID: 920
    neXtProt AC: NX_P01730

  • Chr Location
    12p13.31; chr12:6789472-6820810 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cd4 mouse models; 1 with human CD4 associations

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100
       Okt4 Epitope Deficiency   OMIM: 613949
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 16 alleles in 20 genetic backgrounds
    77 phenotypes from multigenic genotypes
    297 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (ENU)
    5
  • Gene trapped
    6
  • Spontaneous
    2
  • Targeted
    18
  • Transgenic
    7
  • Incidental Mutations
Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023420 VEGA Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
transcript OTTMUST00000056904 VEGA | MGI Sequence Detail 3108 Not Applicable  
polypeptide OTTMUSP00000027399 VEGA | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 53
    Genomic 15
    cDNA 34
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11981, MGD-MRK-1858
References
more
  • Summaries
    All 506
    Developmental Gene Expression 27
    Diseases 4
    Gene Ontology 59
    Phenotypes 297
  • Earliest
    J:5358 Snell GD, et al., Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11
  • Latest
    J:231914 Stauss D, et al., The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. EMBO J. 2016 Apr 15;35(8):881-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory