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Cd4
Gene Detail
 Symbol
Name
ID
Cd4
CD4 antigen
MGI:88335
STS D6Mit24
Synonyms L3T4, Ly-4
Feature Type protein coding gene
Genetic Map
Chromosome 6
59.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr6:124864692-124888221 bp, - strand
From VEGA annotation of GRCm38

  23530 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD4
Gene Tree: Cd4

Human
homologs
Human Homolog CD4, CD4 molecule
NCBI Gene ID 920
neXtProt AC  NX_P01730
Human Synonyms  CD4mut
Human Chr (Location)  12p13.31; chr12:6789472-6820810 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD4
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Chemically induced (ENU)(4) Gene trapped(6) Spontaneous(2) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Cd4 interacts with 208 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cell adhesion, cell surface receptor signaling pathway, ...
Component cell surface, endoplasmic reticulum lumen, ...
Function coreceptor activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (141)    Tissues (46)    Images (3)
Theiler Stages: 23, 26, 28
Assay TypeResults
Immunohistochemistry 3
RT-PCR 138
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(15) cDNA(34) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023420 (Evidence)
Ensembl Gene ModelENSMUSG00000023274 (Evidence)
Entrez Gene12504 (Evidence)
UniGene2209
DFCITC1584295, TC1621323, TC1754381
DoTSDT.87068508, DT.91436625, DT.94130300
NIA Mouse Gene IndexU027855
Consensus CDS ProjectCCDS20535.1
International Mouse Knockout Project StatusCd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023420 VEGA Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
transcript OTTMUST00000056904 VEGA | MGI Sequence Detail 3108 Not Applicable 
polypeptide OTTMUSP00000027399 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(4)
Polymorphisms All PCR and RFLP(8) : PCR(6) RFLP(2) SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015274 CD4, extracellular
InterPro IPR013151 Immunoglobulin
InterPro IPR008424 Immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003596 Immunoglobulin V-set, subgroup
InterPro IPR021963 T cell CD4 receptor C-terminal region
InterPro IPR000973 T-cell surface antigen CD4
Protein Ontology PR:000001004 CD4 molecule
References (Earliest) J:5358 Snell GD, et al., Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11
(Latest) J:211549 Cuzzone DA, et al., IL-6 regulates adipose deposition and homeostasis in lymphedema. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1426-34
All references(493)
Other
accession IDs
MGD-MRK-11981, MGD-MRK-1858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory