Rr95 Other Genome Feature Detail

Summary

• Symbol
  Rr95
• Name
  regulatory region 95
• Synonyms
  Cd4 maturation enhancer, E4m

• Feature Type
  enhancer
• IDs
  MGI:6833885

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:267930: chr6:124835251-124835615 (NCBIm37) chr6:124862196-124862560 (GRCm39)

• Genetic Map
  Chromosome 6, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  1
• Targeted
  2
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of this Cd4 T cell maturation enhancer affects commitment and maturation of helper and regulatory T cells.

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:267930 Kojo S, et al., Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene. Nat Commun. 2018 Sep 5;9(1):3593
• Latest
  J:333574 Teghanemt A, et al., CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477