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Bmp2 Gene Detail
Summary
  • Symbol
    Bmp2
  • Name
    bone morphogenetic protein 2
  • Synonyms
    Bmp2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:88177
    NCBI Gene: 12156
  • Gene Overview
    MyGene.info: BMP2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:133552159-133562885 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 65.21 cM
  • Mapping Data
    21 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88177
protein coding gene Chr2:133552159-133562896 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026551
protein coding gene Chr2:137213173-137224742 (+)
A/J MGP_AJ_G0026515
protein coding gene Chr2:131604920-131616052 (+)
AKR/J MGP_AKRJ_G0026489
protein coding gene Chr2:135421304-135431997 (+)
BALB/cJ MGP_BALBcJ_G0026527
protein coding gene Chr2:132026375-132037421 (+)
C3H/HeJ MGP_C3HHeJ_G0026270
protein coding gene Chr2:135865028-135876338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026972
protein coding gene Chr2:141374428-141387660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024349
protein coding gene Chr2:126294214-126305288 (+)
CAST/EiJ MGP_CASTEiJ_G0025731
protein coding gene Chr2:136187860-136197803 (+)
CBA/J MGP_CBAJ_G0026250
protein coding gene Chr2:146628611-146644765 (+)
DBA/2J MGP_DBA2J_G0026384
protein coding gene Chr2:130985371-130997000 (+)
FVB/NJ MGP_FVBNJ_G0026348
protein coding gene Chr2:129619214-129629877 (+)
LP/J MGP_LPJ_G0026488
protein coding gene Chr2:137440579-137451631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026368
protein coding gene Chr2:150388758-150411077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027027
protein coding gene Chr2:135381378-135392099 (+)
PWK/PhJ MGP_PWKPhJ_G0025467
protein coding gene Chr2:130598618-130607892 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025269
protein coding gene Chr2:134531705-134543829 (+)
WSB/EiJ MGP_WSBEiJ_G0025805
protein coding gene Chr2:136306374-136319704 (+)



Homology
more
  • Human Ortholog
    BMP2, bone morphogenetic protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    BMP2, bone morphogenetic protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDA2, BMP2A, SSFSC
  • Links
    NCBI Gene ID: 650
    neXtProt AC: NX_P12643
    UniProt: P12643

  • Chr Location
    20p12.3; chr20:6767700-6780280 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human BMP2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 9 alleles in 11 genetic backgrounds
    54 phenotypes from multigenic genotypes
    5 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 7.5-9 with failure of the proamniotic canal to close and abnormal development of the heart in the exocoelomic cavity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027358 Ensembl Gene Model | MGI Sequence Detail 10727 C57BL/6J ±  kb
    transcript ENSMUST00000028836 Ensembl | MGI Sequence Detail 3555 Not Applicable  
    polypeptide ENSMUSP00000028836 Ensembl | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 5
      cDNA 41
      Primer pair 17
      Other 32

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1593, MGD-MRK-1595, MGI:2138975
    References
    more
    • Summaries
      All 685
      Developmental Gene Expression 451
      Gene Ontology 63
      Phenotypes 67
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:265181 Kim BJ, et al., RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects. Dis Model Mech. 2018 Aug 28;11(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory