Bmp2
Gene Detail

Symbol Name ID

Bmp2 bone morphogenetic protein 2 MGI:88177

STS

D2Mit279

Synonyms

Bmp2a

Feature Type

protein coding gene

Genetic Map

Chromosome 2

65.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr2:133552159-133562885 bp, + strand From VEGA annotation of GRCm38   10727 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp2

Human homologs

Human Homolog		BMP2, bone morphogenetic protein 2
NCBI Gene ID		650
neXtProt AC		NX_P12643
Human Synonyms		BDA2, BMP2A
Human Chr (Location)		20p12; chr20:6748745-6760910 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human BMP2

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygous null mutants die at embryonic day 7.5-9 with failure of the proamniotic canal to close and abnormal development of the heart in the exocoelomic cavity.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (139 annotations)

Process	activation of MAPK activity, atrioventricular valve morphogenesis, ...
Component	cell surface, cytoplasm, ...
Function	BMP receptor binding, cytokine activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (348 records)
Data Summary: Results (582)    Tissues (379)    Images (186)
Theiler Stages: 2, 3, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	456
Northern blot	27
RT-PCR	95

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) Genomic(4) cDNA(36) Primer pair(10) Other(16)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015653 (Evidence)
Ensembl Gene Model	ENSMUSG00000027358 (Evidence)
Entrez Gene	12156 (Evidence)
UniGene	103205
DFCI	TC1585369, TC1696815
DoTS	DT.110741164, DT.55261797, DT.87072185, DT.91323910
NIA Mouse Gene Index	U002513, U155078
Consensus CDS Project	CCDS16782.1
International Mouse Knockout Project Status	Bmp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015653	VEGA Gene Model | MGI Sequence Detail	10727	C57BL/6J
transcript	OTTMUST00000037190	VEGA | MGI Sequence Detail	3555	Not Applicable
polypeptide	OTTMUSP00000016666	VEGA | MGI Sequence Detail	394	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000164	BMP2

References

(Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(497)

Other accession IDs

MGD-MRK-1593, MGD-MRK-1595, MGI:2138975