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Bmp2
Gene Detail
 Symbol
Name
ID
Bmp2
bone morphogenetic protein 2
MGI:88177
STS D2Mit279
Synonyms Bmp2a
Feature Type protein coding gene
Genetic Map
Chromosome 2
65.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr2:133552159-133562885 bp, + strand
From VEGA annotation of GRCm38

  10727 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp2

Human
homologs
Human Homolog BMP2, bone morphogenetic protein 2
NCBI Gene ID 650
neXtProt AC  NX_P12643
Human Synonyms  BDA2, BMP2A
Human Chr (Location)  20p12; chr20:6768098-6780263 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human BMP2
Alleles
and
phenotypes
All alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die at embryonic day 7.5-9 with failure of the proamniotic canal to close and abnormal development of the heart in the exocoelomic cavity.
 
Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (140 annotations)
Process activation of MAPK activity, atrioventricular valve morphogenesis, ...
Component cell surface, cytoplasm, ...
Function BMP receptor binding, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (369 records)
Data Summary: Results (740)    Tissues (505)    Images (219)
Theiler Stages: 2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 614
Northern blot 27
RT-PCR 95
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(72) Genomic(4) cDNA(38) Primer pair(11) Other(19)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015653 (Evidence)
Ensembl Gene ModelENSMUSG00000027358 (Evidence)
Entrez Gene12156 (Evidence)
UniGene103205
DFCITC1585369, TC1696815
DoTSDT.110741164, DT.55261797, DT.87072185, DT.91323910
NIA Mouse Gene IndexU002513, U155078
Consensus CDS ProjectCCDS16782.1
International Mouse Knockout Project StatusBmp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015653 VEGA Gene Model | MGI Sequence Detail 10727 C57BL/6J ±  kb
transcript OTTMUST00000037190 VEGA | MGI Sequence Detail 3555 Not Applicable 
polypeptide OTTMUSP00000016666 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000164 BMP2
References (Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:209351 Prashar P, et al., Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207
All references(526)
Other
accession IDs
MGD-MRK-1593, MGD-MRK-1595, MGI:2138975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory