About   Help   FAQ
Bmp2
Gene Detail
Symbol

Name
ID
Bmp2
bone morphogenetic protein 2
MGI:88177
STS
Synonyms
Bmp2a
Feature Type
protein coding gene
Genetic Map
Chromosome 2
65.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr2:133552159-133562885 bp, + strand
From VEGA annotation of GRCm38

  10727 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: BMP2
Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp2

Human
homologs
BMP2, bone morphogenetic protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 650
neXtProt AC: NX_P12643

Human Synonyms: BDA2, BMP2A

Human Chr (Location): 20p12; chr20:6767694-6780263 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BMP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die at embryonic day 7.5-9 with failure of the proamniotic canal to close and abnormal development of the heart in the exocoelomic cavity.
 
Phenotype Images(5)
Interactions
Bmp2 interacts with 267 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (145 annotations)
Process activation of MAPK activity, atrioventricular valve morphogenesis, ...
Component cell surface, cytoplasm, ...
Function BMP receptor binding, cytokine activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (386 records)
Data Summary: Results (787)    Tissues (522)    Images (224)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 623
Northern blot 27
RT-PCR 133
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BMP2 ; Xenbase bmp2 ; ZFIN bmp2a, bmp2b    NEW 
Molecular
reagents
All nucleic(76) Genomic(4) cDNA(39) Primer pair(12) Other(21)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015653 (Evidence)
Ensembl Gene Model ENSMUSG00000027358 (Evidence)
Entrez Gene 12156 (Evidence)
UniGene 103205
DFCI TC1585369, TC1696815
DoTS DT.110741164, DT.55261797, DT.87072185, DT.91323910
NIA Mouse Gene Index U002513, U155078
Consensus CDS Project CCDS16782.1
International Mouse Phenotyping Consortium Status Bmp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015653 VEGA Gene Model | MGI Sequence Detail 10727 C57BL/6J ±  kb
transcript OTTMUST00000037190 VEGA | MGI Sequence Detail 3555 Not Applicable 
polypeptide OTTMUSP00000016666 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000164 BMP2
References
(Earliest) J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
(Latest) J:218259 Hill CR, et al., Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015 Feb;244(2):122-33
All references(552)
Other
accession IDs
MGD-MRK-1593, MGD-MRK-1595, MGI:2138975

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory