Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables cytokine activity. Involved in several processes, including heart development; mesenchymal cell proliferation involved in ureteric bud development; and positive regulation of extracellular matrix constituent secretion. Acts upstream of or within several processes, including forebrain development; heart development; and positive regulation of cell differentiation. Located in extracellular space. Is active in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and limb. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); hemochromatosis type 1; otosclerosis; short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).

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Gene Ontology Evidence Code Abbreviations:

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