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Atp5a1
Gene Detail
Symbol

Name
ID
Atp5a1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
MGI:88115
Synonyms
Atpm, D18Ertd206e, Mom2
Feature Type
protein coding gene
Genetic Map
Chromosome 18
52.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr18:77773729-77782869 bp, + strand
From VEGA annotation of GRCm38

  9141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2985  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATP5A1
Protein SuperFamily: ATP synthase subunit alpha
Gene Tree: Atp5a1

Human
homologs
ATP5A1, ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 498
neXtProt AC: NX_P25705

Human Synonyms: ATP5A, ATP5AL2, ATPM, COXPD22, hATP1, HEL-S-123m, MC5DN4, MOM2, OMR, ORM

Human Chr (Location): 18q21; chr18:46084144-46104233 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ATP5A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) QTL(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying a targeted mutation of this gene display preweaning and embryonic lethality. Heterozygous mutants exhibit decreased body weight and lean body mass and reduced circulating insulin, serum albumin, and total protein levels.
 
Interactions
Atp5a1 interacts with 66 markers (Mir1a-1, Mir1a-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process ATP biosynthetic process, ATP hydrolysis coupled proton transport, ...
Component COP9 signalosome, extracellular exosome, ...
Function ADP binding, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (96)    Tissues (96)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 2
cDNA source data(1470)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase atp5a1 ; ZFIN atp5a1    NEW 
Molecular
reagents
All nucleic(1473) cDNA(1470) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017510 (Evidence)
Ensembl Gene Model ENSMUSG00000025428 (Evidence)
Entrez Gene 11946 (Evidence)
UniGene 276137
DFCI TC1573626, TC1614537, TC1675093
DoTS DT.101720876, DT.101720877, DT.101741473, DT.91296129, DT.91380142, DT.91585541, DT.94380670, DT.94380716, DT.94380788
NIA Mouse Gene Index U018919
Consensus CDS Project CCDS29358.1
International Mouse Phenotyping Consortium Status Atp5a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017510 VEGA Gene Model | MGI Sequence Detail 9141 C57BL/6J ±  kb
transcript OTTMUST00000042520 VEGA | MGI Sequence Detail 2471 Not Applicable 
polypeptide OTTMUSP00000019113 VEGA | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004100 ATPase, alpha/beta subunit, N-terminal
InterPro IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
InterPro IPR023366 ATPase, F1/A1 complex, alpha subunit, N-terminal
InterPro IPR005294 ATPase, F1 complex, alpha subunit
InterPro IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
InterPro IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000004453 ATP synthase subunit alpha, mitochondrial
References
(Earliest) J:14987 Davisson M, et al., Nomenclature of the ATPase loci. Mouse Genome. 1991;89:5
(Latest) J:200082 White JK, et al., Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 2013 Jul 18;154(2):452-64
All references(61)
Other
accession IDs
MGD-MRK-1468, MGD-MRK-1477, MGI:1098570, MGI:1891402, MGI:2147192, MGI:2147287, MGI:2147288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory