Apoa2
Gene Detail

Symbol Name ID

Apoa2 apolipoprotein A-II MGI:88050

Synonyms

Alp-2, Apoa-2, ApoA-II, Hdl-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(79)

Sequence Map

Chr1:171225054-171226379 bp, + strand From VEGA annotation of GRCm38   1326 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Apoa2

Human homologs

Human Homolog		APOA2, apolipoprotein A-II
NCBI Gene ID		336
neXtProt AC		NX_P02652
Human Synonyms		apoAII, Apo-AII, ApoA-II
Human Chr (Location)		1q23.3; chr1:161192083-161193418 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human APOA2

Alleles and phenotypes

All alleles(12) : Targeted(3) Gene trapped(6) Other(3)
 

Homozygous null mutation of this gene results in a reduction of total cholesterol, HDL cholesterol, free fatty acids, insulin, and glucose levels in both the fasted and unfasted states. Strain specific alleles have been associated with varying degrees of amyloidosis.

 

Gene Ontology (GO) classifications

All GO classifications: (63 annotations)

Process	beta-glucoside transport, cholesterol efflux, ...
Component	chylomicron, extracellular region, ...
Function	apolipoprotein receptor binding, cholesterol binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (117)    Tissues (95)    Images (24)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	117

cDNA source data(427)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(439) Genomic(5) cDNA(429) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021666 (Evidence)
Ensembl Gene Model	ENSMUSG00000005681 (Evidence)
Entrez Gene	11807 (Evidence)
UniGene	389209
DFCI	TC1571962
DoTS	DT.101325874, DT.40149378, DT.99868528
NIA Mouse Gene Index	U001080
Consensus CDS Project	CCDS35773.1
International Mouse Knockout Project Status	Apoa2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021666	VEGA Gene Model | MGI Sequence Detail	1326	C57BL/6J
transcript	OTTMUST00000051437	VEGA | MGI Sequence Detail	470	Not Applicable
polypeptide	OTTMUSP00000024207	VEGA | MGI Sequence Detail	102	Not Applicable

All sequences(41) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(12) : PCR(1) RFLP(11) SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006801	Apolipoprotein A-II (ApoA-II)
Protein Ontology	PR:000004142	apolipoprotein A-II

References

(Earliest) J:7017 Lusis AJ, et al., Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983 Apr 25;258(8):5071-8
(Latest) J:175686 Cote M, et al., Apolipoprotein A-I, A-II, and H mRNA and protein accumulation sites in the developing lung in late gestation. BMC Res Notes. 2011;4:235
All references(134)

Other accession IDs

MGD-MRK-10688, MGD-MRK-1289, MGD-MRK-1365, MGD-MRK-1368