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Apoa2 Gene Detail
Summary
  • Symbol
    Apoa2
  • Name
    apolipoprotein A-II
  • Synonyms
    Alp-2, Apoa-2, ApoA-II, Hdl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88050
    NCBI Gene: 11807
  • Alliance
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    11 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:171052623-171053948 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.22 cM
  • Mapping Data
    77 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88050
protein coding gene Chr1:171049133-171053948 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016747
protein coding gene Chr1:177005836-177007160 (+)
A/J MGP_AJ_G0016727
protein coding gene Chr1:169806490-169807817 (+)
AKR/J MGP_AKRJ_G0016693
protein coding gene Chr1:174892267-174893592 (+)
BALB/cJ MGP_BALBcJ_G0016688
protein coding gene Chr1:170288996-170290320 (+)
C3H/HeJ MGP_C3HHeJ_G0016511
protein coding gene Chr1:175137087-175138411 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017149
protein coding gene Chr1:182889449-182890774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014857
protein coding gene Chr1:161486859-161488164 (+)
CAST/EiJ MGP_CASTEiJ_G0016092
protein coding gene Chr1:174761338-174762663 (+)
CBA/J MGP_CBAJ_G0016486
protein coding gene Chr1:189404691-189406010 (+)
DBA/2J MGP_DBA2J_G0016593
protein coding gene Chr1:168645504-168646823 (+)
FVB/NJ MGP_FVBNJ_G0016589
protein coding gene Chr1:166994363-166995687 (+)
LP/J MGP_LPJ_G0016664
protein coding gene Chr1:178126940-178128264 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016616
protein coding gene Chr1:196688166-196689486 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017186
protein coding gene Chr1:174763228-174764555 (+)
PWK/PhJ MGP_PWKPhJ_G0015878
protein coding gene Chr1:167868472-167869800 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015662
protein coding gene Chr1:173547578-173548899 (+)
WSB/EiJ MGP_WSBEiJ_G0016154
protein coding gene Chr1:174881658-174883023 (+)



Homology
more
  • Human Ortholog
    APOA2, apolipoprotein A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOA2, apolipoprotein A2
  • Synonyms
    apoAII, Apo-AII, ApoA-II
  • Links
    NCBI Gene ID: 336
    neXtProt AC: NX_P02652
    UniProt: P02652

  • Chr Location
    1q23.3; chr1:161222292-161223631 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation of this gene results in a reduction of total cholesterol, HDL cholesterol, free fatty acids, insulin, and glucose levels in both the fasted and unfasted states. Strain specific alleles have been associated with varying degrees of amyloidosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005681 Ensembl Gene Model | MGI Sequence Detail 1326 C57BL/6J ±  kb
    transcript ENSMUST00000111321 Ensembl | MGI Sequence Detail 518 Not Applicable  
    polypeptide ENSMUSP00000106953 Ensembl | MGI Sequence Detail 102 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 444
      Genomic 5
      cDNA 432
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10688, MGD-MRK-1289, MGD-MRK-1365, MGD-MRK-1368
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 37
    • Earliest
      J:7017 Lusis AJ, et al., Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983 Apr 25;258(8):5071-8
    • Latest
      J:322813 Cui X, et al., Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway. Dis Model Mech. 2022 Mar 1;15(3):dmm049327

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory