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Apoa2
Gene Detail
Symbol

Name
ID
Apoa2
apolipoprotein A-II
MGI:88050
Synonyms
Alp-2, Apoa-2, ApoA-II, Hdl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(77)
Sequence Map
Chr1:171225054-171226379 bp, + strand
From VEGA annotation of GRCm38

  1326 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: APOA2
Gene Tree: Apoa2

Human
homologs
APOA2, apolipoprotein A-II
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 336
neXtProt AC: NX_P02652

Human Synonyms: apoAII, Apo-AII, ApoA-II

Human Chr (Location): 1q23.3; chr1:161222293-161223628 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human APOA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(6) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in a reduction of total cholesterol, HDL cholesterol, free fatty acids, insulin, and glucose levels in both the fasted and unfasted states. Strain specific alleles have been associated with varying degrees of amyloidosis.
 
Interactions
Apoa2 interacts with 6 markers (Mir93, Mir194-2, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process beta-glucoside transport, cholesterol efflux, ...
Component blood microparticle, chylomicron, ...
Function apolipoprotein receptor binding, cholesterol binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (117)    Tissues (95)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(427)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(439) Genomic(5) cDNA(429) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021666 (Evidence)
Ensembl Gene Model ENSMUSG00000005681 (Evidence)
Entrez Gene 11807 (Evidence)
UniGene 389209
DFCI TC1571962
DoTS DT.101325874, DT.40149378, DT.94289848, DT.97370616, DT.99868528
NIA Mouse Gene Index U001080
Consensus CDS Project CCDS35773.1
International Mouse Phenotyping Consortium Status Apoa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021666 VEGA Gene Model | MGI Sequence Detail 1326 C57BL/6J ±  kb
transcript OTTMUST00000051428 VEGA | MGI Sequence Detail 518 Not Applicable 
polypeptide OTTMUSP00000024198 VEGA | MGI Sequence Detail 102 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(9) UniProt(2)
Polymorphisms
All PCR and RFLP(12) : PCR(1) RFLP(11) SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006801 Apolipoprotein A-II (ApoA-II)
Protein Ontology PR:000004142 apolipoprotein A-II
References
(Earliest) J:7017 Lusis AJ, et al., Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983 Apr 25;258(8):5071-8
(Latest) J:219198 Luo H, et al., Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart. Lab Invest. 2015 Mar;95(3):320-33
All references(129)
Other
accession IDs
MGD-MRK-10688, MGD-MRK-1289, MGD-MRK-1365, MGD-MRK-1368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory