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Apoa2
Gene Detail
Symbol

Name
ID
Apoa2
apolipoprotein A-II
MGI:88050
Synonyms
Alp-2, Apoa-2, ApoA-II, Hdl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(77)
Sequence Map
Chr1:171225054-171226379 bp, + strand
From VEGA annotation of GRCm38

  1326 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Apoa2

Human
homologs
Human Homolog APOA2, apolipoprotein A-II
NCBI Gene ID 336
neXtProt AC  NX_P02652
Human Synonyms  apoAII, Apo-AII, ApoA-II
Human Chr (Location)  1q23.3; chr1:161222293-161223628 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human APOA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in a reduction of total cholesterol, HDL cholesterol, free fatty acids, insulin, and glucose levels in both the fasted and unfasted states. Strain specific alleles have been associated with varying degrees of amyloidosis.
 
Interactions
Apoa2 interacts with 6 markers (Mir93, Mir194-2, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process beta-glucoside transport, cholesterol efflux, ...
Component blood microparticle, chylomicron, ...
Function apolipoprotein receptor binding, cholesterol binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (117)    Tissues (95)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(427)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(439) Genomic(5) cDNA(429) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021666 (Evidence)
Ensembl Gene ModelENSMUSG00000005681 (Evidence)
Entrez Gene11807 (Evidence)
UniGene389209
DFCITC1571962
DoTSDT.101325874, DT.40149378, DT.99868528
NIA Mouse Gene IndexU001080
Consensus CDS ProjectCCDS35773.1
International Mouse Knockout Project StatusApoa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021666 VEGA Gene Model | MGI Sequence Detail 1326 C57BL/6J ±  kb
transcript OTTMUST00000051428 VEGA | MGI Sequence Detail 518 Not Applicable 
polypeptide OTTMUSP00000024198 VEGA | MGI Sequence Detail 102 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(12) : PCR(1) RFLP(11) SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006801 Apolipoprotein A-II (ApoA-II)
Protein Ontology PR:000004142 apolipoprotein A-II
References
(Earliest) J:7017 Lusis AJ, et al., Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983 Apr 25;258(8):5071-8
(Latest) J:175686 Cote M, et al., Apolipoprotein A-I, A-II, and H mRNA and protein accumulation sites in the developing lung in late gestation. BMC Res Notes. 2011;4:235
All references(133)
Other
accession IDs
MGD-MRK-10688, MGD-MRK-1289, MGD-MRK-1365, MGD-MRK-1368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory