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Agtr1a Gene Detail
Summary
  • Symbol
    Agtr1a
  • Name
    angiotensin II receptor, type 1a
  • Synonyms
    1810074K20Rik, Agt1ar, Agtr-1a, Agtr1a, Angtr-1a, AT1, AT1a, MGC:37610
  • Feature Type
    protein coding gene
  • IDs
    MGI:87964
    NCBI Gene: 11607
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:30520424-30566850 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 13.19 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1209 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87964
 protein coding gene Chr13:30520339-30566850 (+)
129S1/SvImJ ENSMUSG00200028276
 protein coding gene Chr13:27679450-27719179 (+)
A/J ENSMUSG00195038341
 protein coding gene Chr13:26830199-26877043 (+)
AKR/J ENSMUSG00220012715
 protein coding gene Chr13:26685327-26732156 (+)
BALB/cJ ENSMUSG00180022432
 protein coding gene Chr13:27130335-27177172 (+)
C3H/HeJ ENSMUSG00175030080
 protein coding gene Chr13:27152836-27199673 (+)
C57BL/6NJ ENSMUSG00215008019
 protein coding gene Chr13:27295679-27342504 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018390
 protein coding gene Chr13:25880992-25926698 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210026161
 protein coding gene Chr13:27096445-27143279 (+)
DBA/2J ENSMUSG00185019055
 protein coding gene Chr13:27915502-27962322 (+)
FVB/NJ ENSMUSG00205023300
 protein coding gene Chr13:26917496-26966953 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230015122
 protein coding gene Chr13:37240154-37286981 (+)
NOD/ShiLtJ ENSMUSG00190034208
 protein coding gene Chr13:27290335-27337145 (+)
NZO/HlLtJ ENSMUSG00225033930
 protein coding gene Chr13:31022935-31069757 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010024445
 protein coding gene Chr13:26413348-26452550 (+)
WSB/EiJ ENSIUOG00005016328
 protein coding gene Chr13:26493052-26532786 (+)



Homology
more
  • Human Ortholog
    AGTR1, angiotensin II receptor type 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGTR1, angiotensin II receptor type 1
  • Synonyms
    AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R
  • Links
    NCBI Gene ID: 185
    UniProt: P30556

  • Chr Location
    3q24; chr3:148697784-148743045 (+)  GRCh38
Human Diseases
more
  • Diseases
    13 with human AGTR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 12 alleles in 11 genetic backgrounds
    38 phenotypes from multigenic genotypes
    285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes hypotension and hyperreninemia, alters drinking behavior and vascular and hemodynamic responses to angiotensin II, and may lead to abnormal physiological response to xenobiotics, abnormal kidney morphology, andreduced cell numbers in specific brain areas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    102
  • cDNA Data
    16
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049115 Ensembl Gene Model | MGI Sequence Detail 46427 C57BL/6J ±  kb
    transcript ENSMUST00000066412 Ensembl | MGI Sequence Detail 2199 Not Applicable  
    polypeptide ENSMUSP00000070958 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 9
      cDNA 16
      Primer pair 7
      Other 1
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1193, MGD-MRK-1195, MGD-MRK-1321, MGI:1919544, MGI:2145268
    References
    more
    • Summaries
      All 433
      Developmental Gene Expression 24
      Gene Ontology 23
      Phenotypes 285
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:390309 Levesque P, et al., Sex-specific contribution of endothelial AT1aRs to avoidance behaviors and BBB changes in a mouse model of PTSD. Neurobiol Dis. 2026 Jul 25;:107547
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory