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Agtr1a
Gene Detail
Symbol

Name
ID
Agtr1a
angiotensin II receptor, type 1a
MGI:87964
Synonyms
1810074K20Rik, Agtr1a, Agtr-1a, Angtr-1a, AT1, AT1a, MGC:37610
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr13:30336441-30382867 bp, + strand
From VEGA annotation of GRCm38

  46427 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: AGTR1
Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr1a

Human
homologs
AGTR1, angiotensin II receptor, type 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 185
neXtProt AC: NX_P30556

Human Synonyms: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R

Human Chr (Location): 3q24; chr3:148697871-148743003 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human AGTR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Radiation induced(1) Targeted(13)
Genomic Mutations involving Agtr1a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes hypotension and hyperreninemia, alters drinking behavior and vascular and hemodynamic responses to angiotensin II, and may lead to abnormal physiological response to xenobiotics, abnormal kidney morphology, and reduced cell numbers in specific brain areas.
 
Interactions
Agtr1a interacts with 173 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (113)    Tissues (54)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
Northern blot 11
RT-PCR 52
cDNA source data(14)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase agtr1    NEW 
Molecular
reagents
All nucleic(27) Genomic(9) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000668 (Evidence)
Ensembl Gene Model ENSMUSG00000049115 (Evidence)
Entrez Gene 11607 (Evidence)
UniGene 35062
DFCI TC1580256, TC1647234
DoTS DT.484595, DT.60100377
NIA Mouse Gene Index U014693
Consensus CDS Project CCDS26415.1
International Mouse Phenotyping Consortium Status Agtr1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000668 VEGA Gene Model | MGI Sequence Detail 46427 C57BL/6J ±  kb
transcript OTTMUST00000001293 VEGA | MGI Sequence Detail 2199 Not Applicable 
polypeptide OTTMUSP00000000614 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000248 Angiotensin II receptor family
InterPro IPR000190 Angiotensin II receptor type 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001251 angiotensin II receptor 1A
References
(Earliest) J:1075 Sasamura H, et al., Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992 May 29;185(1):253-9
(Latest) J:220970 Young CN, et al., Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Mol Metab. 2015 Apr;4(4):337-43
All references(263)
Other
accession IDs
MGD-MRK-1193, MGD-MRK-1195, MGD-MRK-1321, MGI:1919544, MGI:2145268

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory