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Agtr1a
Gene Detail
 Symbol
Name
ID
Agtr1a
angiotensin II receptor, type 1a
MGI:87964
Synonyms 1810074K20Rik, Agtr1a, Agtr-1a, Angtr-1a, AT1, AT1a, MGC:37610
Feature Type protein coding gene
Genetic Map
Chromosome 13
13.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr13:30336441-30382867 bp, + strand
From VEGA annotation of GRCm38

  46427 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr1a

Human
homologs
Human Homolog AGTR1, angiotensin II receptor, type 1
NCBI Gene ID 185
neXtProt AC  NX_P30556
Human Synonyms  AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
Human Chr (Location)  3q24; chr3:148697871-148743003 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human AGTR1
Alleles
and
phenotypes
All alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes hypotension and hyperreninemia, alters drinking behavior and vascular and hemodynamic responses to angiotensin II, and may lead to abnormal physiological response to xenobiotics, abnormal kidney morphology, and reduced cell numbers in specific brain areas.
 
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process activation of Janus kinase activity, angiotensin-activated signaling pathway, ...
Component basolateral plasma membrane, cell, ...
Function angiotensin type II receptor activity, angiotensin type I receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (113)    Tissues (54)    Images (21)
Theiler Stages: 19, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 50
Northern blot 11
RT-PCR 52
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(9) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000000668 (Evidence)
Ensembl Gene ModelENSMUSG00000049115 (Evidence)
Entrez Gene11607 (Evidence)
UniGene35062
DFCITC1580256, TC1647234
DoTSDT.484595, DT.60100377
NIA Mouse Gene IndexU014693
Consensus CDS ProjectCCDS26415.1
International Mouse Knockout Project StatusAgtr1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000668 VEGA Gene Model | MGI Sequence Detail 46427 C57BL/6J ±  kb
transcript OTTMUST00000001293 VEGA | MGI Sequence Detail 2199 Not Applicable 
polypeptide OTTMUSP00000000614 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(269 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000248 Angiotensin II receptor family
InterPro IPR000190 Angiotensin II receptor type 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001251 angiotensin II receptor 1A
References (Earliest) J:1075 Sasamura H, et al., Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992 May 29;185(1):253-9
(Latest) J:207416 Ichikawa D, et al., Renoprotective effect of renal liver-type fatty acid binding protein and angiotensin II type 1a receptor loss in renal injury caused by RAS activation. Am J Physiol Renal Physiol. 2014 Mar;306(6):F655-63
All references(250)
Other
accession IDs
MGD-MRK-1193, MGD-MRK-1195, MGD-MRK-1321, MGI:1919544, MGI:2145268

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory