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Adrb2
Gene Detail
Symbol

Name
ID
Adrb2
adrenergic receptor, beta 2
MGI:87938
Synonyms
Adrb-2, Badm, beta 2-adrenoceptor, beta 2-AR, Gpcr7
Feature Type
protein coding gene
Genetic Map
Chromosome 18
35.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr18:62177817-62179959 bp, - strand
From Ensembl annotation of GRCm38

  2143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb2

Human
homologs
Human Homolog ADRB2, adrenoceptor beta 2, surface
NCBI Gene ID 154
neXtProt AC  NX_P07550
Human Synonyms  ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Human Chr (Location)  5q31-q32; chr5:148826593-148828634 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human ADRB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Adrb2 interacts with 172 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (92)    Tissues (50)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 70
RT-PCR 18
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(3) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000045730 (Evidence)
Entrez Gene11555 (Evidence)
UniGene5598
DFCITC1582092, TC1613432, TC1691586
DoTSDT.101725457, DT.530376, DT.99856810
NIA Mouse Gene IndexU038482
Consensus CDS ProjectCCDS29289.1
International Mouse Knockout Project StatusAdrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045730 Ensembl Gene Model | MGI Sequence Detail 2143 C57BL/6J ±  kb
transcript ENSMUST00000053640 Ensembl | MGI Sequence Detail 2143 Not Applicable 
polypeptide ENSMUSP00000062256 Ensembl | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000332 Adrenergic receptor beta 2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001193 beta-2 adrenergic receptor
References
(Earliest) J:13915 Markovac J, et al., Genetic variation in beta-adrenergic receptors. Mouse News Lett. 1982;66:69
(Latest) J:213275 Chiarella SE, et al., beta(2)-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest. 2014 Jul 1;124(7):2935-46
All references(161)
Other
accession IDs
MGD-MRK-1144, MGD-MRK-1147, MGD-MRK-1494, MGD-MRK-16385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory