About   Help   FAQ
Adrb2
Gene Detail
Symbol

Name
ID
Adrb2
adrenergic receptor, beta 2
MGI:87938
Synonyms
Adrb-2, Badm, beta 2-adrenoceptor, beta 2-AR, Gpcr7
Feature Type
protein coding gene
Genetic Map
Chromosome 18
35.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr18:62177817-62179959 bp, - strand
From Ensembl annotation of GRCm38

  2143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ADRB2
Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb2

Human
homologs
ADRB2, adrenoceptor beta 2, surface
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 154
neXtProt AC: NX_P07550

Human Synonyms: ADRB2R, ADRBR, B2AR, BAR, BETA2AR

Human Chr (Location): 5q31-q32; chr5:148826593-148828634 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ADRB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Adrb2 interacts with 172 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (92)    Tissues (50)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 70
RT-PCR 18
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adrb2 ; ZFIN adrb2a, adrb2b    NEW 
Molecular
reagents
All nucleic(31) Genomic(3) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000045730 (Evidence)
Entrez Gene 11555 (Evidence)
UniGene 5598
DFCI TC1582092, TC1613432, TC1691586
DoTS DT.101725457, DT.530376, DT.99856810
NIA Mouse Gene Index U038482
Consensus CDS Project CCDS29289.1
International Mouse Phenotyping Consortium Status Adrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045730 Ensembl Gene Model | MGI Sequence Detail 2143 C57BL/6J ±  kb
transcript ENSMUST00000053640 Ensembl | MGI Sequence Detail 2143 Not Applicable 
polypeptide ENSMUSP00000062256 Ensembl | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000332 Adrenergic receptor beta 2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001193 beta-2 adrenergic receptor
References
(Earliest) J:13915 Markovac J, et al., Genetic variation in beta-adrenergic receptors. Mouse News Lett. 1982;66:69
(Latest) J:222190 Wang WC, et al., Targeted transgenesis identifies Galphas as the bottleneck in beta2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L775-80
All references(166)
Other
accession IDs
MGD-MRK-1144, MGD-MRK-1147, MGD-MRK-1494, MGD-MRK-16385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory