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Adrb2 Gene Detail
Summary
  • Symbol
    Adrb2
  • Name
    adrenergic receptor, beta 2
  • Synonyms
    Adrb-2, Badm, beta 2-adrenoceptor, beta 2-AR, Gpcr7
  • Feature Type
    protein coding gene
  • IDs
    MGI:87938
    NCBI Gene: 11555
  • Gene Overview
    MyGene.info: ADRB2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:62177817-62179959 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 35.10 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87938
protein coding gene Chr18:62177713-62179981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024488
protein coding gene Chr18:62120637-62122781 (-)
A/J MGP_AJ_G0024455
protein coding gene Chr18:59437117-59439261 (-)
AKR/J MGP_AKRJ_G0024425
protein coding gene Chr18:61085796-61087928 (-)
BALB/cJ MGP_BALBcJ_G0024454
protein coding gene Chr18:59578213-59580357 (-)
C3H/HeJ MGP_C3HHeJ_G0024222
protein coding gene Chr18:61313167-61315309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024901
protein coding gene Chr18:63785545-63787687 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022332
protein coding gene Chr18:58981935-58984098 (-)
CAST/EiJ MGP_CASTEiJ_G0023695
protein coding gene Chr18:61203010-61205145 (-)
CBA/J MGP_CBAJ_G0024192
protein coding gene Chr18:65853226-65855370 (-)
DBA/2J MGP_DBA2J_G0024322
protein coding gene Chr18:59110430-59112572 (-)
FVB/NJ MGP_FVBNJ_G0024288
protein coding gene Chr18:58518965-58521113 (-)
LP/J MGP_LPJ_G0024406
protein coding gene Chr18:62002506-62004650 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024317
protein coding gene Chr18:67408880-67411012 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024948
protein coding gene Chr18:61295205-61297353 (-)
PWK/PhJ MGP_PWKPhJ_G0023438
protein coding gene Chr18:59349872-59352009 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023244
protein coding gene Chr18:61512391-61514540 (-)
WSB/EiJ MGP_WSBEiJ_G0023759
protein coding gene Chr18:61153718-61155850 (-)



Homology
more
  • Human Ortholog
    ADRB2, adrenoceptor beta 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADRB2, adrenoceptor beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRB2R, ADRBR, B2AR, BAR, BETA2AR
  • Links
    NCBI Gene ID: 154
    neXtProt AC: NX_P07550
    UniProt: P07550

  • Chr Location
    5q32; chr5:148826593-148828634 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human ADRB2 associations

Human Disease Mouse Models
      
IDs
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    65 phenotypes from multigenic genotypes
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045730 Ensembl Gene Model | MGI Sequence Detail 2143 C57BL/6J ±  kb
    transcript ENSMUST00000053640 Ensembl | MGI Sequence Detail 2143 Not Applicable  
    polypeptide ENSMUSP00000062256 Ensembl | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 3
      cDNA 25
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1144, MGD-MRK-1147, MGD-MRK-1494, MGD-MRK-16385
    References
    more
    • Summaries
      All 258
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 30
      Phenotypes 134
    • Earliest
      J:7332 Markovac J, et al., Genetic variation in beta-adrenergic receptors in mice: a magnesium effect determined by a single gene. Genet Res. 1983 Oct;42(2):159-68
    • Latest
      J:262732 Nguyen MN, et al., Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure. Sci Rep. 2018 May 29;8(1):8213

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory