Adrb2
Gene Detail

Symbol Name ID

Adrb2 adrenergic receptor, beta 2 MGI:87938

Synonyms

Adrb-2, Badm, beta 2-adrenoceptor, beta 2-AR, Gpcr7

Feature Type

protein coding gene

Genetic Map

Chromosome 18

35.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr18:62177817-62179959 bp, - strand From Ensembl annotation of GRCm38   2143 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30948  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: beta adrenergic receptor
Gene Tree: Adrb2

Human homologs

Human Homolog		ADRB2, adrenoceptor beta 2, surface
NCBI Gene ID		154
neXtProt AC		NX_P07550
Human Synonyms		ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Human Chr (Location)		5q31-q32; chr5:148206156-148208197 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ADRB2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (88 annotations)

Process	activation of adenylate cyclase activity, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	apical plasma membrane, axon, ...
Function	adenylate cyclase binding, adrenergic receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (95)    Tissues (52)    Images (40)
Theiler Stages: 3, 4, 5, 12, 14, 18, 19, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	70
RT-PCR	21

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(3) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000045730 (Evidence)
Entrez Gene	11555 (Evidence)
UniGene	5598
DFCI	TC1582092, TC1613432, TC1691586
DoTS	DT.101725457, DT.530376, DT.99856810
NIA Mouse Gene Index	U038482
Consensus CDS Project	CCDS29289.1
International Mouse Knockout Project Status	Adrb2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000045730	Ensembl Gene Model | MGI Sequence Detail	2143	C57BL/6J
transcript	ENSMUST00000053640	Ensembl | MGI Sequence Detail	2143	Not Applicable
polypeptide	ENSMUSP00000062256	Ensembl | MGI Sequence Detail	418	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(4) : SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002233	Adrenergic receptor
InterPro	IPR000332	Adrenergic receptor, beta 2
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001193	beta-2 adrenergic receptor

References

(Earliest) J:13915 Markovac J, et al., Genetic variation in beta-adrenergic receptors. Mouse News Lett. 1982;66:69
(Latest) J:195073 Arteaga-Solis E, et al., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8;17(1):35-48
All references(146)

Other accession IDs

MGD-MRK-1144, MGD-MRK-1147, MGD-MRK-1494, MGD-MRK-16385