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Adrb2 Gene Detail
Summary
  • Symbol
    Adrb2
  • Name
    adrenergic receptor, beta 2
  • Synonyms
    Adrb-2, Badm, beta 2-adrenoceptor, beta 2-AR, Gpcr7
  • Feature Type
    protein coding gene
  • IDs
    MGI:87938
    NCBI Gene: 11555
  • Gene Overview
    MyGene.info: ADRB2
Location & Maps
more
  • Sequence Map
    Chr18:62177817-62179959 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2143 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 35.10 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    ADRB2, adrenoceptor beta 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADRB2, adrenoceptor beta 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADRB2R, ADRBR, B2AR, BAR, BETA2AR
  • Links
    NCBI Gene ID: 154
    neXtProt AC: NX_P07550

  • Chr Location
    5q31-q32; chr5:148826593-148828634 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human ADRB2 associations

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807
Beta-2-Adrenergic Receptor; ADRB2   OMIM: 109690
Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    44 phenotypes from multigenic genotypes
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045730 Ensembl Gene Model | MGI Sequence Detail 2143 C57BL/6J ±  kb
transcript ENSMUST00000053640 Ensembl | MGI Sequence Detail 2143 Not Applicable  
polypeptide ENSMUSP00000062256 Ensembl | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 3
    cDNA 24
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1144, MGD-MRK-1147, MGD-MRK-1494, MGD-MRK-16385
References
more
  • Summaries
    All 172
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 25
    Phenotypes 109
  • Earliest
    J:13915 Markovac J, et al., Genetic variation in beta-adrenergic receptors. Mouse News Lett. 1982;66:69
  • Latest
    J:230661 Gabanyi I, et al., Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell. 2016 Jan 28;164(3):378-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory