Adrb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adrb2
adrenergic receptor, beta 2
MGI:87938

40 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adrb2^em1(IMPC)Mbp/Adrb2^em1(IMPC)Mbp C57BL/6N-Adrb2^em1(IMPC)Mbp/MbpMmucd	abnormal auditory brainstem response	J:211773
	abnormal eye morphology	J:211773
	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	enlarged heart	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	small liver	J:211773
Adrb2^tm1Bkk/Adrb2⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal bone resorption	J:97566
	abnormal osteoclast differentiation	J:97566
	decreased bone resorption	J:97566
	increased bone volume	J:97566
Adrb2^tm1Bkk/Adrb2^tm1Bkk FVB.129-Adrb2^tm1Bkk	abnormal epididymal fat pad morphology	J:55552
	abnormal heart rate	J:55552
	normal behavior/neurological phenotype	J:55552
	decreased body weight	J:55552
	decreased mean systemic arterial blood pressure	J:55552
	decreased respiratory quotient	J:55552
	enhanced exercise endurance	J:55552
	normal homeostasis/metabolism phenotype	J:55552
	increased systemic arterial blood pressure	J:55552
Adrb2^tm1Bkk/Adrb2^tm1Bkk involves: 129S1/Sv * 129X1/SvJ	abnormal bone resorption	J:97566
	abnormal osteoblast physiology	J:97566
	abnormal osteoclast differentiation	J:97566
	abnormal osteoclast morphology	J:97566
	abnormal osteoclast physiology	J:97566
	decreased bone resorption	J:97566
	increased bone mass	J:97566
Adrb2^tm1Bkk/Adrb2^tm1Bkk involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	abnormal electroretinogram waveform feature	J:204379
	abnormal Muller cell morphology	J:204379
	abnormal retina ganglion layer morphology	J:204379
	abnormal retina morphology	J:204379
	decreased a-wave amplitude	J:204379
	decreased b-wave amplitude	J:204379
	decreased retina ganglion cell number	J:204379
	increased retina apoptosis	J:204379
	increased tumor necrosis factor secretion	J:204379
Adrb2^tm1Kry/Adrb2^tm1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB	abnormal insulin secretion	J:145998
	decreased circulating glucose level	J:145998
	increased circulating insulin level	J:145998

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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