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Cfd
Gene Detail
Symbol

Name
ID
Cfd
complement factor D (adipsin)
MGI:87931
Synonyms
Adn, D component (adipsin) of complement, DF, factor D
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr10:79890853-79892656 bp, + strand
From Ensembl annotation of GRCm38

  1804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20453  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CFD
Protein SuperFamily: trypsin
Gene Tree: Cfd

Human
homologs
CFD, complement factor D (adipsin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1675
neXtProt AC: NX_P00746

Human Synonyms: ADIPSIN, ADN, DF, PFD

Human Chr (Location): 19p13.3; chr19:859665-863624 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CFD

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show impaired complement activation by alternative pathway activators, and increased susceptibility to pneumococcal infection.
 
Interactions
Cfd interacts with 13 markers (Mir125a, Mir125b-1, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process complement activation, alternative pathway, immune system process, ...
Component extracellular exosome, extracellular region, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
RT-PCR 2
cDNA source data(167)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cfd ; ZFIN cfd    NEW 
Molecular
reagents
All nucleic(177) Genomic(7) cDNA(168) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000061780 (Evidence)
Entrez Gene 11537 (Evidence)
UniGene 4407
DFCI TC1575938
DoTS DT.110628823, DT.496957
NIA Mouse Gene Index U089277
EC 3.4.21.46
Consensus CDS Project CCDS23995.1
International Mouse Phenotyping Consortium Status Cfd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061780 Ensembl Gene Model | MGI Sequence Detail 1804 C57BL/6J ±  kb
transcript ENSMUST00000061653 Ensembl | MGI Sequence Detail 923 Not Applicable 
polypeptide ENSMUSP00000056836 Ensembl | MGI Sequence Detail 259 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms
PCR(2) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000005376 complement factor D
References
(Earliest) J:34985 Spiegelman BM, et al., Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983 Aug 25;258(16):10083-9
(Latest) J:223071 Cresci GA, et al., Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl(4)-induced injury. Mol Immunol. 2015 Mar;64(1):9-17
All references(64)
Other
accession IDs
MGD-MRK-1130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory