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Cfd
Gene Detail
 Symbol
Name
ID
Cfd
complement factor D (adipsin)
MGI:87931
Synonyms Adn, D component (adipsin) of complement, DF, factor D
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr10:79890853-79892656 bp, + strand
From NCBI annotation of GRCm38

  1804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20453  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Cfd

Human
homologs
Human Homolog CFD, complement factor D (adipsin)
NCBI Gene ID 1675
neXtProt AC  NX_P00746
Human Synonyms  ADIPSIN, ADN, DF, PFD
Human Chr (Location)  19p13.3; chr19:859665-863624 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CFD
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show impaired complement activation by alternative pathway activators, and increased susceptibility to pneumococcal infection.
 
Interactions
Cfd interacts with 13 markers (Mir125a, Mir125b-1, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process complement activation, alternative pathway, immune system process, ...
Component extracellular region, extracellular space, ...
Function catalytic activity, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (1)
Theiler Stages: 28
Assay TypeResults
Northern blot 6
RT-PCR 2
cDNA source data(167)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(177) Genomic(7) cDNA(168) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000061780 (Evidence)
Entrez Gene11537 (Evidence)
UniGene4407
DFCITC1575938
DoTSDT.110628823, DT.496957
NIA Mouse Gene IndexU089277
EC3.4.21.46
Consensus CDS ProjectCCDS23995.1
International Mouse Knockout Project StatusCfd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11537 NCBI Gene Model | MGI Sequence Detail 1804 C57BL/6J ±  kb
transcript NM_013459 RefSeq | MGI Sequence Detail 927 Not Specified 
polypeptide P03953 UniProt | EBI | MGI Sequence Detail 259 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms PCR(2) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005376 complement factor D
Graphical View of Protein Domain Structure
References (Earliest) J:34985 Spiegelman BM, et al., Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983 Aug 25;258(16):10083-9
(Latest) J:204756 Arend WP, et al., Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. J Immunol. 2013 Jun 15;190(12):6423-33
All references(66)
Other
accession IDs
MGD-MRK-1130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory