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Cfd Gene Detail
Summary
  • Symbol
    Cfd
  • Name
    complement factor D (adipsin)
  • Synonyms
    Adn, D component (adipsin) of complement, DF, factor D
  • Feature Type
    protein coding gene
  • IDs
    MGI:87931
    NCBI Gene: 11537
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79890853-79892655 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87931
protein coding gene Chr10:79890853-79892660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017467
protein coding gene Chr10:80451858-80453661 (+)
A/J MGP_AJ_G0017445
protein coding gene Chr10:77645948-77647751 (+)
AKR/J MGP_AKRJ_G0017406
protein coding gene Chr10:79762750-79764553 (+)
BALB/cJ MGP_BALBcJ_G0017407
protein coding gene Chr10:77872735-77874538 (+)
C3H/HeJ MGP_C3HHeJ_G0017230
protein coding gene Chr10:79866561-79868364 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017861
protein coding gene Chr10:83228407-83230210 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015549
protein coding gene Chr10:73873132-73874938 (+)
CAST/EiJ MGP_CASTEiJ_G0016797
protein coding gene Chr10:80052469-80054272 (+)
CBA/J MGP_CBAJ_G0017202
protein coding gene Chr10:86458097-86459900 (+)
DBA/2J MGP_DBA2J_G0017308
protein coding gene Chr10:76860994-76862797 (+)
FVB/NJ MGP_FVBNJ_G0017302
protein coding gene Chr10:76037383-76039186 (+)
LP/J MGP_LPJ_G0017379
protein coding gene Chr10:80928434-80930237 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017328
protein coding gene Chr10:88427917-88429720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017902
protein coding gene Chr10:79746865-79748668 (+)
PWK/PhJ MGP_PWKPhJ_G0016578
protein coding gene Chr10:76726341-76728144 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016367
protein coding gene Chr10:78721680-78724498 (+)
WSB/EiJ MGP_WSBEiJ_G0016857
protein coding gene Chr10:79770498-79772301 (+)



Homology
more
  • Human Ortholog
    CFD, complement factor D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CFD, complement factor D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADIPSIN, ADN, DF, PFD
  • Links
    NCBI Gene ID: 1675
    neXtProt AC: NX_P00746
    UniProt: P00746

  • Chr Location
    19p13.3; chr19:859659-863569 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20453
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CFD
  • Protein SuperFamily
  • Gene Tree
    Cfd
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show impaired complement activation by alternative pathway activators, and increased susceptibility to pneumococcal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061780 Ensembl Gene Model | MGI Sequence Detail 1803 C57BL/6J ±  kb
transcript ENSMUST00000061653 Ensembl | MGI Sequence Detail 922 Not Applicable  
polypeptide ENSMUSP00000056836 Ensembl | MGI Sequence Detail 259 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 178
    Genomic 7
    cDNA 169
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1130
References
more
  • Summaries
    All 74
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:260966 Wu X, et al., Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy. J Immunol. 2018 Apr 15;200(8):2786-2797

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory