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Cfd Gene Detail
Summary
  • Symbol
    Cfd
  • Name
    complement factor D (adipsin)
  • Synonyms
    Adn, D component (adipsin) of complement, DF, factor D
  • Feature Type
    protein coding gene
  • IDs
    MGI:87931
    NCBI Gene: 11537
Location & Maps
more
  • Sequence Map
    Chr10:79890853-79892656 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1804 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CFD, complement factor D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CFD, complement factor D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADIPSIN, ADN, DF, PFD
  • Links
    NCBI Gene ID: 1675
    neXtProt AC: NX_P00746

  • Chr Location
    19p13.3; chr19:859665-863624 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20453
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CFD
  • Protein SuperFamily
  • Gene Tree
    Cfd
Human Diseases
more
  • Diseases
    1 with human CFD associations

Human Disease Mouse Models
       Complement Factor D Deficiency; CFDD   OMIM: 613912
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Cfd
  • Incidental Mutations
Mice homozygous for a knock-out allele show impaired complement activation by alternative pathway activators, and increased susceptibility to pneumococcal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061780 Ensembl Gene Model | MGI Sequence Detail 1804 C57BL/6J ±  kb
transcript ENSMUST00000061653 Ensembl | MGI Sequence Detail 923 Not Applicable  
polypeptide ENSMUSP00000056836 Ensembl | MGI Sequence Detail 259 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 177
    Genomic 7
    cDNA 168
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1130
References
more
  • Summaries
    All 60
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:34985 Spiegelman BM, et al., Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983 Aug 25;258(16):10083-9
  • Latest
    J:223071 Cresci GA, et al., Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl(4)-induced injury. Mol Immunol. 2015 Mar;64(1):9-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory