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Gfral Gene Detail
Summary
  • Symbol
    Gfral
  • Name
    GDNF family receptor alpha like
  • Synonyms
    GRAL, GRAL-A, GRAL-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3607786
    NCBI Gene: 404194
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:76164102-76213657 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3607786
protein coding gene Chr9:76164102-76213657 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035047
protein coding gene Chr9:76520673-76574476 (-)
A/J MGP_AJ_G0035028
protein coding gene Chr9:73841614-73887834 (-)
AKR/J MGP_AKRJ_G0034957
protein coding gene Chr9:75616313-75665869 (-)
BALB/cJ MGP_BALBcJ_G0035020
protein coding gene Chr9:73510597-73557751 (-)
C3H/HeJ MGP_C3HHeJ_G0034729
protein coding gene Chr9:76072036-76123983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035538
protein coding gene Chr9:78554850-78604922 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032449
protein coding gene Chr9:73167094-73210906 (-)
CAST/EiJ MGP_CASTEiJ_G0034051
protein coding gene Chr9:76427329-76475879 (-)
CBA/J MGP_CBAJ_G0034701
protein coding gene Chr9:81251354-81305283 (-)
DBA/2J MGP_DBA2J_G0034861
protein coding gene Chr9:73506351-73553322 (-)
FVB/NJ MGP_FVBNJ_G0034803
protein coding gene Chr9:72795219-72846964 (-)
LP/J MGP_LPJ_G0034942
protein coding gene Chr9:76758185-76805685 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034844
protein coding gene Chr9:82355316-82404128 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035561
protein coding gene Chr9:75776191-75822884 (-)
PWK/PhJ MGP_PWKPhJ_G0033755
protein coding gene Chr9:73778999-73823037 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033588
protein coding gene Chr9:76009261-76060684 (-)
WSB/EiJ MGP_WSBEiJ_G0034163
protein coding gene Chr9:75695856-75744858 (-)



Homology
more
  • Human Ortholog
    GFRAL, GDNF family receptor alpha like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GFRAL, GDNF family receptor alpha like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA360D14.1, C6orf144, GRAL, UNQ9356
  • Links
    NCBI Gene ID: 389400
    neXtProt AC: NX_Q6UXV0
    UniProt: Q6UXV0

  • Chr Location
    6p12.1; chr6:55327469-55402493 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout leads to increased susceptibility to diet-induced obesity caused by overeating and reduced glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 404194 NCBI Gene Model | MGI Sequence Detail 49556 C57BL/6J ±  kb
transcript NM_205844 RefSeq | MGI Sequence Detail 2080 C57BL/6  
polypeptide Q6SJE0 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 34
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:254140 Hsu JY, et al., Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature. 2017 Oct 12;550(7675):255-259

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory