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Iqsec2
Gene Detail
 Symbol
Name
ID
Iqsec2
IQ motif and Sec7 domain 2
MGI:3528396
Feature Type protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:152144272-152225236 bp, + strand
From VEGA annotation of GRCm38

  80965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19407  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Iqsec2

Human
homologs
Human Homolog IQSEC2, IQ motif and Sec7 domain 2
NCBI Gene ID 23096
neXtProt AC  NX_Q5JU85
Human Synonyms  BRAG1, MRX1
Human Chr (Location)  Xp11.22; chrX:53227633-53321334 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IQSEC2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Iqsec2 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process actin cytoskeleton organization, positive regulation of GTPase activity, ...
Component cell junction, cytoplasm, ...
Function ARF guanyl-nucleotide exchange factor activity, protein binding
External Resources: FuncBase
Expression
cDNA source data(29)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(29) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019682 (Evidence)
Ensembl Gene ModelENSMUSG00000041115 (Evidence)
Entrez Gene245666 (Evidence)
UniGene33027
DFCITC1603197, TC1604355, TC1657132
DoTSDT.101203140, DT.101298172, DT.522635, DT.91565174, DT.94229075
NIA Mouse Gene IndexU020325
Consensus CDS ProjectCCDS41177.1, CCDS53224.1
International Mouse Knockout Project StatusIqsec2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019682 VEGA Gene Model | MGI Sequence Detail 80965 C57BL/6J ±  kb
transcript OTTMUST00000047113 VEGA | MGI Sequence Detail 6017 Not Applicable 
polypeptide OTTMUSP00000021283 VEGA | MGI Sequence Detail 1488 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000904 SEC7-like
InterPro IPR023394 SEC7-like, alpha orthogonal bundle
Protein Ontology PR:000031098 IQ motif and SEC7 domain-containing protein 2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory