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Ticam2 Gene Detail
Summary
  • Symbol
    Ticam2
  • Name
    TIR domain containing adaptor molecule 2
  • Synonyms
    Tirp, TRAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040056
    NCBI Gene: 225471
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46691298-46707600 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040056
 protein coding gene Chr18:46690358-46707600 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024408
 protein coding gene Chr18:45370359-45386057 (-)
A/J MGP_AJ_G0024375
 protein coding gene Chr18:43739435-43756206 (-)
AKR/J MGP_AKRJ_G0024344
 protein coding gene Chr18:44934774-44951738 (-)
BALB/cJ MGP_BALBcJ_G0024375
 protein coding gene Chr18:43837393-43855621 (-)
C3H/HeJ MGP_C3HHeJ_G0024142
 protein coding gene Chr18:45025953-45043540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024819
 protein coding gene Chr18:46968679-46985702 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022254
 protein coding gene Chr18:43561934-43577400 (-)
CAST/EiJ MGP_CASTEiJ_G0023616
 protein coding gene Chr18:44977149-44992289 (-)
CBA/J MGP_CBAJ_G0024111
 protein coding gene Chr18:48235068-48250513 (-)
DBA/2J MGP_DBA2J_G0024241
 protein coding gene Chr18:43346528-43361927 (-)
FVB/NJ MGP_FVBNJ_G0024207
 protein coding gene Chr18:42911738-42927528 (-)
LP/J MGP_LPJ_G0024325
 protein coding gene Chr18:45439116-45456847 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024238
 protein coding gene Chr18:49585103-49602334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024866
 protein coding gene Chr18:44855489-44872647 (-)
PWK/PhJ MGP_PWKPhJ_G0023360
 protein coding gene Chr18:43491123-43506796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023165
 protein coding gene Chr18:45003748-45020310 (-)
WSB/EiJ MGP_WSBEiJ_G0023679
 protein coding gene Chr18:44751554-44768107 (-)



Homology
more
  • Human Ortholog
    TICAM2, TIR domain containing adaptor molecule 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TICAM2, TIR domain containing adaptor molecule 2
  • Synonyms
    MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
  • Links
    NCBI Gene ID: 353376
    neXtProt AC: NX_Q86XR7
    UniProt: Q86XR7

  • Chr Location
    5q22.3; chr5:115578496-115602479 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ticam2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 5 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene affects TLR4-mediated immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 225471 NCBI Gene Model | MGI Sequence Detail 16303 C57BL/6J ±  kb
transcript NM_173394 RefSeq | MGI Sequence Detail 3264 C57BL/6  
polypeptide Q8BJQ4 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001750 TIR domain-containing adapter molecule 2
    (term hierarchy)
  • InterPro Domains
    IPR046946 TIR domain-containing adapter molecule 1/2
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
    IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 1
References
more
  • Summaries
    All 123
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 12
    Phenotypes 38
  • Earliest
    J:84379 Bin LH, et al., TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003 Jul 4;278(27):24526-32
  • Latest
    J:344278 Wang J, et al., TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity. Front Immunol. 2023;14:1297329
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory