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Ticam2 Gene Detail
Summary
  • Symbol
    Ticam2
  • Name
    toll-like receptor adaptor molecule 2
  • Synonyms
    Tirp, TRAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040056
    NCBI Gene: 225471
  • Gene Overview
    MyGene.info: TICAM2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46559155-46574533 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 24.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040056
protein coding gene Chr18:46558231-46574533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024408
protein coding gene Chr18:45370359-45386057 (-)
A/J MGP_AJ_G0024375
protein coding gene Chr18:43739435-43756206 (-)
AKR/J MGP_AKRJ_G0024344
protein coding gene Chr18:44934774-44951738 (-)
BALB/cJ MGP_BALBcJ_G0024375
protein coding gene Chr18:43837393-43855621 (-)
C3H/HeJ MGP_C3HHeJ_G0024142
protein coding gene Chr18:45025953-45043540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024819
protein coding gene Chr18:46968679-46985702 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022254
protein coding gene Chr18:43561934-43577400 (-)
CAST/EiJ MGP_CASTEiJ_G0023616
protein coding gene Chr18:44977149-44992289 (-)
CBA/J MGP_CBAJ_G0024111
protein coding gene Chr18:48235068-48250513 (-)
DBA/2J MGP_DBA2J_G0024241
protein coding gene Chr18:43346528-43361927 (-)
FVB/NJ MGP_FVBNJ_G0024207
protein coding gene Chr18:42911738-42927528 (-)
LP/J MGP_LPJ_G0024325
protein coding gene Chr18:45439116-45456847 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024238
protein coding gene Chr18:49585103-49602334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024866
protein coding gene Chr18:44855489-44872647 (-)
PWK/PhJ MGP_PWKPhJ_G0023360
protein coding gene Chr18:43491123-43506796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023165
protein coding gene Chr18:45003748-45020310 (-)
WSB/EiJ MGP_WSBEiJ_G0023679
protein coding gene Chr18:44751554-44768107 (-)



Homology
more
  • Human Ortholog
    TICAM2, toll like receptor adaptor molecule 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TICAM2, toll like receptor adaptor molecule 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
  • Links
    NCBI Gene ID: 353376
    neXtProt AC: NX_Q86XR7
    UniProt: Q86XR7

  • Chr Location
    5q22.3; chr5:115578496-115602479 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 5 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene affects TLR4-mediated immune responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056130 Ensembl Gene Model | MGI Sequence Detail 15379 C57BL/6J ±  kb
transcript ENSMUST00000070084 Ensembl | MGI Sequence Detail 2340 Not Applicable  
polypeptide ENSMUSP00000066239 Ensembl | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001750 TIR domain-containing adapter molecule 2
  • InterPro Domains
    IPR015720 TMP21-related
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
    IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 1
References
more
  • Summaries
    All 99
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 28
  • Earliest
    J:84379 Bin LH, et al., TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem. 2003 Jul 4;278(27):24526-32
  • Latest
    J:253990 Takizawa H, et al., Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory