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Phenotypes Associated with This Genotype
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam2tm1Aki mutation (0 available); any Ticam2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• defects in MyD88-independent TLR4 signaling resulting in impaired splenocyte proliferation and upregulation of surface molecules
• impaired responses to LPS stimulation
• reduced IL-6 production when induced with LPS
• increased susceptibility to SARS-CoV MA15
• greater SARS-CoV induced weight loss than control mice
• pulmonary hemorrhage scores were significantly higher in mutant mice at 4 d postinfection compared to controls
• virus load is significantly higher at day 2 postinfection compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:270045

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory