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Targeted Allele Detail
Symbol: Ticam2tm1Aki
Name: TIR domain containing adaptor molecule 2; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3040182
Synonyms: Ticam2-, Tram_, TRAM-
Gene: Ticam2  Location: Chr18:46691298-46707600 bp, - strand  Genetic Position: Chr18, 24.65 cM
Alliance: Ticam2tm1Aki page
Germline Transmission:  Earliest citation of germline transmission: J:86256
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.0 kb fragment encompassing the entire coding region of this single-exon gene was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of immunoprecipitated lysates from homozygous mutant macrophages. (J:86256)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ticam2 Mutation:  13 strains or lines available
Original:  J:86256 Yamamoto M, et al., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144-50
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory