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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ticam2tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3040182
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ticam2tm1Aki/Ticam2tm1Aki involves: C57BL/6 MGI:3040184


Genotype
MGI:3040184
hm1
Allelic
Composition
Ticam2tm1Aki/Ticam2tm1Aki
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam2tm1Aki mutation (0 available); any Ticam2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• defects in MyD88-independent TLR4 signaling resulting in impaired splenocyte proliferation and upregulation of surface molecules
• impaired responses to LPS stimulation
• reduced IL-6 production when induced with LPS
• increased susceptibility to SARS-CoV MA15
• greater SARS-CoV induced weight loss than control mice
• pulmonary hemorrhage scores were significantly higher in mutant mice at 4 d postinfection compared to controls
• virus load is significantly higher at day 2 postinfection compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:270045





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory