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Syngap1 Gene Detail
Summary
  • Symbol
    Syngap1
  • Name
    synaptic Ras GTPase activating protein 1 homolog (rat)
  • Synonyms
    Syngap
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039785
    NCBI Gene: 240057
  • Gene Overview
    MyGene.info: SYNGAP1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26941408-26972434 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 13.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039785
protein coding gene Chr17:26941253-26972434 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023412
protein coding gene Chr17:26165695-26203612 (+)
A/J MGP_AJ_G0023369
protein coding gene Chr17:25371262-25403863 (+)
AKR/J MGP_AKRJ_G0023335
protein coding gene Chr17:25504846-25537782 (+)
BALB/cJ MGP_BALBcJ_G0023374
protein coding gene Chr17:25613288-25646854 (+)
C3H/HeJ MGP_C3HHeJ_G0023135
protein coding gene Chr17:25880263-25913208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023817
protein coding gene Chr17:27271608-27307153 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021291
protein coding gene Chr17:22781280-22813507 (+)
CAST/EiJ MGP_CASTEiJ_G0022636
protein coding gene Chr17:25807631-25841637 (+)
CBA/J MGP_CBAJ_G0023109
protein coding gene Chr17:28223541-28257500 (+)
DBA/2J MGP_DBA2J_G0023241
protein coding gene Chr17:24933682-24966065 (+)
FVB/NJ MGP_FVBNJ_G0023210
protein coding gene Chr17:24718743-24751744 (+)
LP/J MGP_LPJ_G0023318
protein coding gene Chr17:26415629-26452354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023228
protein coding gene Chr17:27738587-27777855 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023858
protein coding gene Chr17:25878102-25909572 (+)
PWK/PhJ MGP_PWKPhJ_G0022386
protein coding gene Chr17:23732576-23764368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022204
protein coding gene Chr17:23914580-23947735 (+)
WSB/EiJ MGP_WSBEiJ_G0022699
protein coding gene Chr17:25900673-25933909 (+)



Homology
more
  • Human Ortholog
    SYNGAP1, synaptic Ras GTPase activating protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYNGAP1, synaptic Ras GTPase activating protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD5, RASA1, RASA5, SYNGAP
  • Links
    NCBI Gene ID: 8831
    neXtProt AC: NX_Q96PV0
    UniProt: Q96PV0

  • Chr Location
    6p21.32; chr6:33420070-33453689 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Syngap1 mouse models; 1 with human SYNGAP1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, and by P3-P4, exhibit small body size and brain, reduced movement and do not feed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 240057 NCBI Gene Model | MGI Sequence Detail 31027 C57BL/6J ±  kb
transcript NM_001281491 RefSeq | MGI Sequence Detail 4023 C57BL/6  
polypeptide F6SEU4 UniProt | EBI | MGI Sequence Detail 1340 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 6
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 13
    Phenotypes 23
  • Earliest
    J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
  • Latest
    J:249826 Tanabe Y, et al., IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2alpha. Nat Commun. 2017 Sep 01;8(1):408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory