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Syngap1
Gene Detail
Symbol

Name
ID
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785
Synonyms
Syngap
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:26941452-26970645 bp, + strand
From Ensembl annotation of GRCm38

  29194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84739  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Syngap1

Human
homologs
Human Homolog SYNGAP1, synaptic Ras GTPase activating protein 1
NCBI Gene ID 8831
neXtProt AC  NX_Q96PV0
Human Synonyms  MRD5, RASA1, RASA5, SYNGAP
Human Chr (Location)  6p21.3; chr6:33420070-33453689 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SYNGAP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Radiation induced(2) Targeted(6)
Genomic Mutations involving Syngap1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit postnatal lethality, and by P3-P4, exhibit small body size and brain, reduced movement and do not feed.
 
Human Diseases Modeled Using Mouse Syngap1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process dendrite development, negative regulation of axonogenesis, ...
Component cell junction, cytoplasm, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000067629 (Evidence)
Entrez Gene240057 (Evidence)
UniGene328888
DFCITC1624908
DoTSDT.110572293, DT.97383935
NIA Mouse Gene IndexU132901
Consensus CDS ProjectCCDS59625.1
International Mouse Knockout Project StatusSyngap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067629 Ensembl Gene Model | MGI Sequence Detail 29194 C57BL/6J ±  kb
transcript ENSMUST00000081285 Ensembl | MGI Sequence Detail 4023 Not Applicable 
polypeptide ENSMUSP00000080038 Ensembl | MGI Sequence Detail 1340 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(32) UniProt(4)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR021887 Protein of unknown function DUF3498
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR023315 SynGAP C2 domain, N-terminal
Protein Ontology PR:000015877 ras GTPase-activating protein SynGAP
References
(Earliest) J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
(Latest) J:199642 Clement JP, et al., SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity. J Neurosci. 2013 Jun 19;33(25):10447-52
All references(38)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory