43 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Syngap1tm1.1Mabk/Syngap1tm1.1Mabk involves: 129S1/Sv * C57BL/6	abnormal hippocampus pyramidal cell morphology	J:93969
	abnormal motor capabilities/coordination/movement	J:93969
	increased miniature excitatory postsynaptic current amplitude	J:93969
	increased miniature excitatory postsynaptic current frequency	J:93969
	increased neuron apoptosis	J:101084
	postnatal growth retardation	J:93969
	postnatal lethality, complete penetrance	J:93969
	tremors	J:93969
	weakness	J:93969
Syngap1tm1.1Mabk/Syngap1tm1.2Mabk Tg(Camk2a-cre)2834Lusc/0 involves: 129S1/Sv * C57BL/6	increased neuron apoptosis	J:101084
	postnatal lethality, incomplete penetrance	J:101084
Syngap1tm1Grnt/Syngap1+ involves: 129P2/OlaHsd * MF1	abnormal spatial learning	J:98903
	impaired synaptic plasticity	J:98903
	reduced long-term potentiation	J:98903
Syngap1tm1Grnt/Syngap1tm1Grnt involves: 129P2/OlaHsd * MF1	decreased body size	J:97490
	postnatal lethality, complete penetrance	J:97490, J:98903
Syngap1tm1Rlh/Syngap1+ involves: 129S1/Sv * 129X1/SvJ	abnormal CNS synaptic transmission	J:193208
	abnormal dendrite morphology	J:193208
	abnormal dendritic spine morphology	J:193208
	abnormal discrimination learning	J:193208
	abnormal excitatory postsynaptic potential	J:193208
	abnormal glutamate-mediated receptor currents	J:193208
	abnormal miniature excitatory postsynaptic currents	J:193208
	abnormal miniature inhibitory postsynaptic currents	J:193208
	audiogenic seizures	J:193208
	normal behavior/neurological phenotype	J:193208
	enhanced AMPA-mediated synaptic currents	J:193208
	hyperactivity	J:193208
	increased miniature inhibitory postsynaptic current amplitude	J:193208
	increased miniature inhibitory postsynaptic current frequency	J:193208
	increased susceptibility to pharmacologically induced seizures	J:193208
	normal nervous system phenotype	J:193208
Syngap1tm1Rlh/Syngap1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	reduced long-term potentiation	J:97391
Syngap1tm1Rlh/Syngap1+ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal social/conspecific interaction behavior	J:194146
	abnormal spatial working memory	J:194146
	decreased anxiety-related response	J:194146
	decreased prepulse inhibition	J:194146
	impaired cued conditioning behavior	J:194146
	increased horizontal stereotypic behavior	J:194146
	increased locomotor activity	J:194146
	increased startle reflex	J:194146
	social withdrawal	J:194146
Syngap1tm1Rlh/Syngap1tm1Rlh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal neuron morphology	J:97391
	abnormal suckling behavior	J:97391
	bradykinesia	J:97391
	decreased body size	J:97391
	decreased brain size	J:97391
	postnatal lethality, complete penetrance	J:97391
Syngap1tm1Rlh/Syngap1tm1Rlh involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	postnatal lethality, complete penetrance	J:194146