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Slc17a8
Gene Detail
 Symbol
Name
ID
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
MGI:3039629
Synonyms Vglut3
Feature Type protein coding gene
Genetic Map
Chromosome 10
44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:89574020-89621253 bp, - strand
From VEGA annotation of GRCm38

  47234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc17a8

Human
homologs
Human Homolog SLC17A8, solute carrier family 17 (vesicular glutamate transporter), member 8
NCBI Gene ID 246213
neXtProt AC  NX_Q8NDX2
Human Synonyms  DFNA25, VGLUT3
Human Chr (Location)  12q23.1; chr12:100357079-100422059 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC17A8
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a null allele exhibit sensorineural hearing loss, cochlear ganglion degeneration, decreased synaptic glutamate release, and nonconvulsive seizures.
 
Human Diseases Modeled Using Mouse Slc17a8 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process ion transport, L-alpha-amino acid transmembrane transport, ...
Component cell junction, cytoplasmic vesicle, ...
Function L-glutamate transmembrane transporter activity, symporter activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (49)    Tissues (14)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 49
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000024564 (Evidence)
Ensembl Gene ModelENSMUSG00000019935 (Evidence)
Entrez Gene216227 (Evidence)
UniGene233921
DFCITC1588448
DoTSDT.101150493, DT.94175810
NIA Mouse Gene IndexU032118
Consensus CDS ProjectCCDS24117.1
International Mouse Knockout Project StatusSlc17a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024564 VEGA Gene Model | MGI Sequence Detail 47234 C57BL/6J ±  kb
transcript OTTMUST00000060329 VEGA | MGI Sequence Detail 4456 Not Applicable 
polypeptide OTTMUSP00000043238 VEGA | MGI Sequence Detail 601 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(736 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000014964 vesicular glutamate transporter 3
References (Earliest) J:91392 Schafer MK, et al., Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002 Dec 27;277(52):50734-48
(Latest) J:204139 Yang FC, et al., Genetic Control of the Segregation of Pain-Related Sensory Neurons Innervating the Cutaneous versus Deep Tissues. Cell Rep. 2013 Dec 12;5(5):1353-64
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory