Slc17a8
Gene Detail

Symbol Name ID

Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 MGI:3039629

Synonyms

Vglut3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:89574020-89621253 bp, - strand From VEGA annotation of GRCm38   47234 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13584  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc17a8

Human homologs

Human Homolog		SLC17A8, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
NCBI Gene ID		246213
neXtProt AC		NX_Q8NDX2
Human Synonyms		DFNA25, VGLUT3
Human Chr (Location)		12q23.1; chr12:100750857-100815837 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC17A8

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele exhibit sensorineural hearing loss, cochlear ganglion degeneration, decreased synaptic glutamate release, and nonconvulsive seizures.

 
Human Diseases Modeled Using Mouse Slc17a8 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	amino acid transmembrane transport, ion transport, ...
Component	cell junction, cytoplasmic vesicle, ...
Function	L-glutamate transmembrane transporter activity, symporter activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (49)    Tissues (14)    Images (15)
Theiler Stages: 23

Assay Type	Results
RNA in situ	49

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000024564 (Evidence)
Ensembl Gene Model	ENSMUSG00000019935 (Evidence)
Entrez Gene	216227 (Evidence)
UniGene	233921
DFCI	TC1588448
DoTS	DT.101150493, DT.94175810
NIA Mouse Gene Index	U032118
Consensus CDS Project	CCDS24117.1
International Mouse Knockout Project Status	Slc17a8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024564	VEGA Gene Model | MGI Sequence Detail	47234	C57BL/6J
transcript	OTTMUST00000060329	VEGA | MGI Sequence Detail	4456	Not Applicable
polypeptide	OTTMUSP00000043238	VEGA | MGI Sequence Detail	601	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(271 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000014964	vesicular glutamate transporter 3

References

(Earliest) J:91392 Schafer MK, et al., Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002 Dec 27;277(52):50734-48
(Latest) J:193903 Lou S, et al., Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J Neurosci. 2013 Jan 16;33(3):870-82
All references(40)