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Hpse2
Gene Detail
 Symbol
Name
ID
Hpse2
heparanase 2
MGI:2685814
Synonyms LOC381226
Feature Type protein coding gene
Genetic Map
Chromosome 19
36.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:42788947-43388311 bp, - strand
From Ensembl annotation of GRCm38

  599365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Hpse2

Human
homologs
Human Homolog HPSE2, heparanase 2 (inactive)
NCBI Gene ID 60495
neXtProt AC  NX_Q8WWQ2
Human Synonyms  HPA2, HPR2, UFS, UFS1
Human Chr (Location)  10q23-q24; chr10:98457077-99235875 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HPSE2
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(8)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hpse2 interacts with 2 markers (Mir1906-1, Mir1906-2)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process carbohydrate metabolic process
Component extracellular region, membrane, ...
Function heparan sulfate proteoglycan binding, hydrolase activity, acting on glycosyl bonds
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 8
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000074852 (Evidence)
Entrez Gene545291 (Evidence)
UniGene442200
DFCITC1616178, TC1642570, TC1765303
DoTSDT.101722394, DT.110867236, DT.91325851, DT.91391916
NIA Mouse Gene IndexU039055, U132267
Consensus CDS ProjectCCDS37993.1
International Mouse Knockout Project StatusHpse2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074852 Ensembl Gene Model | MGI Sequence Detail 599365 C57BL/6J ±  kb
transcript ENSMUST00000099428 Ensembl | MGI Sequence Detail 1779 Not Applicable 
polypeptide ENSMUSP00000097026 Ensembl | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(7) UniProt(1)
Polymorphisms SNPs within 2kb(4089 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR005199 Glycoside hydrolase, family 79
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000008742 heparanase-2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:169197 Daly SB, et al., Mutations in HPSE2 cause urofacial syndrome. Am J Hum Genet. 2010 Jun 11;86(6):963-9
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory