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Hpse2
Gene Detail
Symbol

Name
ID
Hpse2
heparanase 2
MGI:2685814
Synonyms
LOC381226
Feature Type
protein coding gene
Genetic Map
Chromosome 19
36.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:42788947-43388311 bp, - strand
From Ensembl annotation of GRCm38

  599365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HPSE2
Gene Tree: Hpse2

Human
homologs
HPSE2, heparanase 2 (inactive)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 60495
neXtProt AC: NX_Q8WWQ2

Human Synonyms: HPA2, HPR2, UFS, UFS1

Human Chr (Location): 10q23-q24; chr10:98457077-99235875 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HPSE2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(8)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hpse2 interacts with 2 markers (Mir1906-1, Mir1906-2)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 8
cDNA source data(10)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase hpse2    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000074852 (Evidence)
Entrez Gene 545291 (Evidence)
UniGene 442200
DFCI TC1616178, TC1642570, TC1765303
DoTS DT.101722394, DT.110867236, DT.91325851, DT.91391916
NIA Mouse Gene Index U039055, U132267
Consensus CDS Project CCDS37993.1
International Mouse Phenotyping Consortium Status Hpse2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074852 Ensembl Gene Model | MGI Sequence Detail 599365 C57BL/6J ±  kb
transcript ENSMUST00000099428 Ensembl | MGI Sequence Detail 1779 Not Applicable 
polypeptide ENSMUSP00000097026 Ensembl | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(15) UniProt(1)
Polymorphisms
SNPs within 2kb(4089 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR005199 Glycoside hydrolase, family 79
InterPro IPR017853 Glycoside hydrolase superfamily
Protein Ontology PR:000008742 heparanase-2
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:219597 Guo C, et al., A mouse model of urofacial syndrome with dysfunctional urination. Hum Mol Genet. 2015 Apr 1;24(7):1991-9
All references(21)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory