About   Help   FAQ
Due to maintenance, access to MGI may be intermittent starting at 10:00 AM ET Thursday, March 30.
Gene trapped Allele Detail
Symbol: Hpse2Gt(OST411605)Lex
Name: heparanase 2; gene trap OST411605, Lexicon Genetics
MGI ID: MGI:4308701
Synonyms: Hpse2-
Gene: Hpse2  Location: Chr19:42774978-43376794 bp, - strand  Genetic Position: Chr19, 36.57 cM
Alliance: Hpse2Gt(OST411605)Lex page
Mutant Cell Line:  OST411605
Germline Transmission:  Earliest citation of germline transmission: J:219597
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
Mutation detailsThe gene trap vector (VICTR48) was inserted into intron 6, resulting in truncation of the carboxyl-terminus. The gene trap allele was expected to generate two separate transcripts, the marker fusion transcript (MFT) consisting of a truncated 5' region and the Neo selection marker, and the OmniBank sequence tag (OST) fusion transcript (OFT). RT-qPCR analysis revealed a ~90% reduction in 5' transcripts and nearly undetectable 3' transcripts (OFT RNA) in P14 mutant bladders. Immunoblot analysis using an antibody that recognizes an N-terminal epitope revealed only a faint signal from mutant bladder tissue. (J:219597)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hpse2 Mutation:  24 strains or lines available
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory