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Wisp3
Gene Detail
 Symbol
Name
ID
Wisp3
WNT1 inducible signaling pathway protein 3
MGI:2685581
Synonyms CCN6, LOC327743
Feature Type protein coding gene
Genetic Map
Chromosome 10
20.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:39150971-39163794 bp, - strand
From NCBI annotation of GRCm38

  12824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Wisp3

Human
homologs
Human Homolog WISP3, WNT1 inducible signaling pathway protein 3
NCBI Gene ID 8838
neXtProt AC  NX_O95389
Human Synonyms  CCN6, LIBC, PPAC, PPD
Human Chr (Location)  6q21; chr6:112025707-112069686 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human WISP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease.
 
Interactions
Wisp3 interacts with 27 markers (Mir27a, Mir27b, Mir183, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of angiogenesis, negative regulation of cell proliferation, ...
Component extracellular region
Function growth factor activity, insulin-like growth factor binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)    Images (7)
Theiler Stages: 11, 17, 19, 20, 21, 23
Assay TypeResults
RNA in situ 7
RT-PCR 1
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(1) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000062074 (Evidence)
Entrez Gene327743 (Evidence)
Consensus CDS ProjectCCDS48537.1
International Mouse Knockout Project StatusWisp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 327743 NCBI Gene Model | MGI Sequence Detail 12824 C57BL/6J ±  kb
transcript NM_001127376 RefSeq | MGI Sequence Detail 1418 Not Specified 
polypeptide D3Z5L9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(8) RefSeq(3) UniProt(1)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR012395 IGFBP-related, CNN
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000017428 WNT1-inducible-signaling pathway protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:94500 Kutz WE, et al., WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan;25(1):414-21
(Latest) J:201718 Hann S, et al., A Wisp3 Cre-knockin allele produces efficient recombination in spermatocytes during early prophase of meiosis I. PLoS One. 2013;8(9):e75116
All references(22)
Other
accession IDs
MGI:3641683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory