Wisp3
Gene Detail

Symbol Name ID

Wisp3 WNT1 inducible signaling pathway protein 3 MGI:2685581

Synonyms

CCN6, LOC327743

Feature Type

protein coding gene

Genetic Map

Chromosome 10

20.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:39150971-39163794 bp, - strand From NCBI annotation of GRCm38   12824 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:77038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, CNN type
Gene Tree: Wisp3

Human homologs

Human Homolog		WISP3, WNT1 inducible signaling pathway protein 3
NCBI Gene ID		8838
neXtProt AC		NX_O95389
Human Synonyms		CCN6, LIBC, PPAC, PPD
Human Chr (Location)		6q21; chr6:112375278-112390889 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WISP3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of angiogenesis, negative regulation of cell proliferation, ...
Component	extracellular region
Function	growth factor activity, insulin-like growth factor binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)    Images (7)
Theiler Stages: 11, 17, 19, 20, 21, 23

Assay Type	Results
RNA in situ	7
RT-PCR	1

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(1) Primer pair(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000062074 (Evidence)
Entrez Gene	327743 (Evidence)
Consensus CDS Project	CCDS48537.1
International Mouse Knockout Project Status	Wisp3

Sequences

Length	Strain/Species
genomic	327743	NCBI Gene Model | MGI Sequence Detail	12824	C57BL/6J
transcript	NM_001127376	RefSeq | MGI Sequence Detail	1418	Not Specified
polypeptide	D3Z5L9	UniProt | EBI | MGI Sequence Detail	354	Not Applicable

All sequences(8) RefSeq(3) UniProt(1)

Protein-related information

Resource	ID	Description
InterPro	IPR006208	Cystine knot
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR012395	IGFBP-related, CNN
InterPro	IPR000867	Insulin-like growth factor-binding protein, IGFBP
InterPro	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000017428	WNT1-inducible-signaling pathway protein 3

Graphical View of Protein Domain Structure

References

(Earliest) J:94500 Kutz WE, et al., WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan;25(1):414-21
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(21)

Other accession IDs

MGI:3641683