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Wisp3 Gene Detail
Summary
  • Symbol
    Wisp3
  • Name
    WNT1 inducible signaling pathway protein 3
  • Synonyms
    CCN6, LOC327743
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685581
    NCBI Gene: 327743
Location & Maps
more
  • Sequence Map
    Chr10:39150971-39163794 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12824 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    WISP3, WNT1 inducible signaling pathway protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WISP3, WNT1 inducible signaling pathway protein 3
    Orthology source: HomoloGene
  • Synonyms
    CCN6, LIBC, PPAC, PPD, WISP-3
  • Links
    NCBI Gene ID: 8838
    neXtProt AC: NX_O95389

  • Chr Location
    6q21; chr6:112053516-112069686 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Wisp3 mouse models; 1 with human WISP3 associations

Human Disease Mouse Models
       Arthropathy, Progressive Pseudorheumatoid, of Childhood; PPAC   OMIM: 208230 View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    11 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Wisp3
  • Incidental Mutations
Homozygous null mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 327743 NCBI Gene Model | MGI Sequence Detail 12824 C57BL/6J ±  kb
transcript NM_001127376 RefSeq | MGI Sequence Detail 1418 Not Specified  
polypeptide D3Z5L9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017428 WNT1-inducible-signaling pathway protein 3
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR012395 IGFBP-related, CNN
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000884 Thrombospondin type-1 (TSP1) repeat
Molecular
Reagents
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  • All nucleic 3
    cDNA 1
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
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MGI:3641683
References
more
  • Summaries
    All 21
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:94500 Kutz WE, et al., WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Mol Cell Biol. 2005 Jan;25(1):414-21
  • Latest
    J:201718 Hann S, et al., A Wisp3 Cre-knockin allele produces efficient recombination in spermatocytes during early prophase of meiosis I. PLoS One. 2013;8(9):e75116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory