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Ccn6 Gene Detail
Summary
  • Symbol
    Ccn6
  • Name
    cellular communication network factor 6
  • Synonyms
    CCN6, LOC327743, Wisp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685581
    NCBI Gene: 327743
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr10:39150971-39163794 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 20.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685581
protein coding gene Chr10:39150970-39163794 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017150
protein coding gene Chr10:37641775-37655676 (-)
A/J MGP_AJ_G0017127
protein coding gene Chr10:36648029-36660776 (-)
AKR/J MGP_AKRJ_G0017087
protein coding gene Chr10:37150348-37163113 (-)
BALB/cJ MGP_BALBcJ_G0017090
protein coding gene Chr10:36674606-36687374 (-)
C3H/HeJ MGP_C3HHeJ_G0016910
protein coding gene Chr10:37471487-37484871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017548
protein coding gene Chr10:38806598-38820269 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015245
protein coding gene Chr10:34638952-34651449 (-)
CAST/EiJ MGP_CASTEiJ_G0016489
protein coding gene Chr10:37616400-37630820 (-)
CBA/J MGP_CBAJ_G0016884
protein coding gene Chr10:40604228-40618112 (-)
DBA/2J MGP_DBA2J_G0016989
protein coding gene Chr10:36169692-36182801 (-)
FVB/NJ MGP_FVBNJ_G0016984
protein coding gene Chr10:35671285-35684069 (-)
LP/J MGP_LPJ_G0017066
protein coding gene Chr10:37612672-37625449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017014
protein coding gene Chr10:41483670-41497647 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017584
protein coding gene Chr10:37137754-37151058 (-)
PWK/PhJ MGP_PWKPhJ_G0016270
protein coding gene Chr10:35991964-36005943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016054
protein coding gene Chr10:36912567-36929312 (-)
WSB/EiJ MGP_WSBEiJ_G0016552
protein coding gene Chr10:37412094-37424823 (-)



Homology
more
  • Human Ortholog
    CCN6, cellular communication network factor 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCN6, cellular communication network factor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LIBC, PPAC, PPD, WISP3, WISP-3
  • Links
    NCBI Gene ID: 8838
    neXtProt AC: NX_O95389
    UniProt: O95389

  • Chr Location
    6q21; chr6:112052813-112069686 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ccn6 mouse models; 1 with human CCN6 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 327743 NCBI Gene Model | MGI Sequence Detail 12824 C57BL/6J ±  kb
    transcript NM_001127376 RefSeq | MGI Sequence Detail 1418 Not Specified  
    polypeptide D3Z5L9 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000017428 WNT1-inducible-signaling pathway protein 3
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012395 IGFBP-related, CNN
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 1
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3641683
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:241259 Martin EE, et al., MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene. 2017 Apr 20;36(16):2275-2285

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory