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Gpr161 Gene Detail
Summary
  • Symbol
    Gpr161
  • Name
    G protein-coupled receptor 161
  • Synonyms
    LOC240888, vl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685054
    NCBI Gene: 240888
  • Gene Overview
    MyGene.info: GPR161
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:165295789-165326745 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.64 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RE2
  • Links
    NCBI Gene ID: 23432
    neXtProt AC: NX_Q8N6U8
    UniProt: Q8N6U8

  • Chr Location
    1q24.2; chr1:168079542-168137667 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17824
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPR161
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049888 VEGA Gene Model | MGI Sequence Detail 30957 C57BL/6J ±  kb
    transcript OTTMUST00000127023 VEGA | MGI Sequence Detail 1827 Not Applicable  
    polypeptide OTTMUSP00000068643 VEGA | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      428 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15400, MGI:98934
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:133308 Wilson DB, et al., Closure of the posterior neuropore in the vl mutant mouse. Anat Embryol (Berl). 1988;178(6):559-63
    • Latest
      J:253972 Hwang SH, et al., The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner. Development. 2018 Jan 8;145(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory