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Gpr161 Gene Detail
Summary
  • Symbol
    Gpr161
  • Name
    G protein-coupled receptor 161
  • Synonyms
    LOC240888, vl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685054
    NCBI Gene: 240888
  • Gene Overview
    MyGene.info: GPR161
Location & Maps
more
  • Sequence Map
    Chr1:165295789-165326745 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30957 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.64 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RE2
  • Links
    NCBI Gene ID: 23432
    neXtProt AC: NX_Q8N6U8

  • Chr Location
    1q24.2; chr1:168079542-168137667 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 17824
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPR161
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Gpr161
  • Incidental Mutations
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049888 VEGA Gene Model | MGI Sequence Detail 30957 C57BL/6J ±  kb
transcript OTTMUST00000127023 VEGA | MGI Sequence Detail 1827 Not Applicable  
polypeptide OTTMUSP00000068643 VEGA | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    428 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-15400, MGI:98934
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:13464 Dickie MM, Vacuolated lens. Mouse News Lett. 1967;36:39-40
  • Latest
    J:222442 Li BI, et al., The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015 Jun 1;402(1):17-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory