Gpr161
Gene Detail

Symbol Name ID

Gpr161 G protein-coupled receptor 161 MGI:2685054

Synonyms

LOC240888, vl

Feature Type

protein coding gene

Genetic Map

Chromosome 1

72.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:165301863-165322930 bp, + strand From Ensembl annotation of GRCm38   21068 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Gpr161

Human homologs

Human Homolog		GPR161, G protein-coupled receptor 161
NCBI Gene ID		23432
neXtProt AC		NX_Q8N6U8
Human Synonyms		RE2
Human Chr (Location)		1q24.2; chr1:168048780-168106905 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	G-protein coupled receptor signaling pathway, multicellular organismal development, ...
Component	cell projection, cilium, ...
Function	G-protein coupled receptor activity, signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (28)    Tissues (24)    Images (14)
Theiler Stages: 12, 13, 15, 17, 19, 20, 22

Assay Type	Results
RNA in situ	22
RT-PCR	6

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(34) Primer pair(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000040836 (Evidence)
Entrez Gene	240888 (Evidence)
UniGene	329929
DFCI	TC1672813, TC1717764
DoTS	DT.101357168
NIA Mouse Gene Index	U166369
International Mouse Knockout Project Status	Gpr161

Sequences

Length	Strain/Species
genomic	ENSMUSG00000040836	Ensembl Gene Model | MGI Sequence Detail	21068	C57BL/6J
transcript	ENSMUST00000178700	Ensembl | MGI Sequence Detail	2903	Not Applicable
polypeptide	ENSMUSP00000136621	Ensembl | MGI Sequence Detail	557	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(146 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001517	G-protein coupled receptor 161

References

(Earliest) J:13464 Dickie MM, Vacuolated lens. Mouse News Lett. 1967;36:39-40
(Latest) J:193395 Mukhopadhyay S, et al., The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell. 2013 Jan 17;152(1-2):210-23
All references(33)

Other accession IDs

MGD-MRK-15400, MGI:98934