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Gpr161 Gene Detail
Summary
  • Symbol
    Gpr161
  • Name
    G protein-coupled receptor 161
  • Synonyms
    LOC240888, vl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685054
    NCBI Gene: 240888
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:165123358-165154314 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 72.64 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685054
 protein coding gene Chr1:165108760-165154314 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016691
 protein coding gene Chr1:170777921-170808818 (+)
A/J MGP_AJ_G0016672
 protein coding gene Chr1:163810096-163841074 (+)
AKR/J MGP_AKRJ_G0016638
 protein coding gene Chr1:168755991-168796340 (+)
BALB/cJ MGP_BALBcJ_G0016633
 protein coding gene Chr1:164295935-164332236 (+)
C3H/HeJ MGP_C3HHeJ_G0016457
 protein coding gene Chr1:168987599-169018650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017094
 protein coding gene Chr1:176507772-176539892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014803
 protein coding gene Chr1:155704655-155744746 (+)
CAST/EiJ MGP_CASTEiJ_G0016037
 protein coding gene Chr1:168595529-168646692 (+)
CBA/J MGP_CBAJ_G0016432
 protein coding gene Chr1:182784808-182823985 (+)
DBA/2J MGP_DBA2J_G0016538
 protein coding gene Chr1:162695228-162733135 (+)
FVB/NJ MGP_FVBNJ_G0016536
 protein coding gene Chr1:161129073-161169895 (+)
LP/J MGP_LPJ_G0016609
 protein coding gene Chr1:171836931-171870556 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016561
 protein coding gene Chr1:190263826-190309356 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017130
 protein coding gene Chr1:168609105-168650603 (+)
PWK/PhJ MGP_PWKPhJ_G0015823
 protein coding gene Chr1:161900195-161935739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015610
 protein coding gene Chr1:167487780-167523778 (+)
WSB/EiJ MGP_WSBEiJ_G0016099
 protein coding gene Chr1:168769160-168810379 (+)



Homology
more
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR161, G protein-coupled receptor 161
  • Synonyms
    RE2
  • Links
    NCBI Gene ID: 23432
    neXtProt AC: NX_Q8N6U8
    UniProt: Q8N6U8

  • Chr Location
    1q24.2; chr1:168079542-168137667 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPR161 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    29
  • cDNA Data
    7
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040836 Ensembl Gene Model | MGI Sequence Detail 30957 C57BL/6J ±  kb
    transcript ENSMUST00000178700 Ensembl | MGI Sequence Detail 1827 Not Applicable  
    polypeptide ENSMUSP00000136621 Ensembl | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15400, MGI:98934
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 12
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:133308 Wilson DB, et al., Closure of the posterior neuropore in the vl mutant mouse. Anat Embryol (Berl). 1988;178(6):559-63
    • Latest
      J:343326 Kim SE, et al., Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development. Dis Model Mech. 2023 Nov 1;16(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory