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Mmp21 Gene Detail
Summary
  • Symbol
    Mmp21
  • Name
    matrix metallopeptidase 21
  • Synonyms
    b2b2458Clo, b2b873Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664387
    NCBI Gene: 214766
  • Gene Overview
    MyGene.info: MMP21
Location & Maps
more
  • Sequence Map
    Chr7:133674270-133680061 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5792 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 77.24 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MMP21, matrix metallopeptidase 21
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MMP21, matrix metallopeptidase 21
    Orthology source: HomoloGene
  • Synonyms
    HTX7, MMP-21
  • Links
    NCBI Gene ID: 118856
    neXtProt AC: NX_Q8N119

  • Chr Location
    10q26.13; chr10:125764939-125785224 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MMP21 associations

Human Disease Mouse Models
       Heterotaxy, Visceral, 7, Autosomal; HTX7   OMIM: 616749
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    30 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    2
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation exhibit heterotaxia and congenital cardiovascular defects including d-loop transposition of the great arteries, tricupid valve atresia, and ventricular septal defect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027351 VEGA Gene Model | MGI Sequence Detail 5792 C57BL/6J ±  kb
transcript OTTMUST00000067639 VEGA | MGI Sequence Detail 1858 Not Applicable  
polypeptide OTTMUSP00000034058 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 5
    Genomic 1
    cDNA 3
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGI:5311342, MGI:5554540
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:83524 Marchenko GN, et al., The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein. Biochem J. 2003 Jun 1;372(Pt 2):503-15
  • Latest
    J:231940 Akawi N, et al., Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Nat Genet. 2015 Nov;47(11):1363-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory