Mmp21
Gene Detail

Symbol Name ID

Mmp21 matrix metallopeptidase 21 MGI:2664387

Synonyms

b2b873Clo

Feature Type

protein coding gene

Genetic Map

Chromosome 7

77.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:133674270-133680061 bp, - strand From VEGA annotation of GRCm38   5792 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp21

Human homologs

Human Homolog		MMP21, matrix metallopeptidase 21
NCBI Gene ID		118856
neXtProt AC		NX_Q8N119
Human Synonyms		MMP-21
Human Chr (Location)		10q26.13; chr10:127455022-127464390 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process, proteolysis
Component	extracellular matrix, extracellular region
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RT-PCR	6

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) Genomic(1) cDNA(3) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000027351 (Evidence)
Ensembl Gene Model	ENSMUSG00000030981 (Evidence)
Entrez Gene	214766 (Evidence)
UniGene	222952
DFCI	TC1593280
DoTS	DT.101351526, DT.111016131
NIA Mouse Gene Index	U029373
EC	3.4.24.-
Consensus CDS Project	CCDS21933.1
International Mouse Knockout Project Status	Mmp21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027351	VEGA Gene Model | MGI Sequence Detail	5792	C57BL/6J
transcript	OTTMUST00000067639	VEGA | MGI Sequence Detail	1858	Not Applicable
polypeptide	OTTMUSP00000034058	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR016293	Peptidase M10A, metazoans
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010481	matrix metalloproteinase-21

References

(Earliest) J:83524 Marchenko GN, et al., The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein. Biochem J. 2003 Jun 1;372(Pt 2):503-15
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)

Other accession IDs

MGI:5311342