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Mmp21
Gene Detail
 Symbol
Name
ID
Mmp21
matrix metallopeptidase 21
MGI:2664387
Synonyms b2b873Clo
Feature Type protein coding gene
Genetic Map
Chromosome 7
77.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:133674270-133680061 bp, - strand
From VEGA annotation of GRCm38

  5792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp21

Human
homologs
Human Homolog MMP21, matrix metallopeptidase 21
NCBI Gene ID 118856
neXtProt AC  NX_Q8N119
Human Synonyms  MMP-21
Human Chr (Location)  10q26.13; chr10:125766453-125775821 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation exhibit heterotaxia and congenital cardiovascular defects including d-loop transposition of the great arteries, tricupid valve atresia, and ventricular septal defect.
 
Phenotype Images(7)
Interactions
Mmp21 interacts with 80 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process hematopoietic progenitor cell differentiation, proteolysis
Component extracellular matrix, extracellular region
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 10, 18, 20, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
RT-PCR 6
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(3) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000027351 (Evidence)
Ensembl Gene ModelENSMUSG00000030981 (Evidence)
Entrez Gene214766 (Evidence)
UniGene222952
DFCITC1593280
DoTSDT.101351526, DT.111016131
NIA Mouse Gene IndexU029373
EC3.4.24.-
Consensus CDS ProjectCCDS21933.1
International Mouse Knockout Project StatusMmp21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027351 VEGA Gene Model | MGI Sequence Detail 5792 C57BL/6J ±  kb
transcript OTTMUST00000067639 VEGA | MGI Sequence Detail 1858 Not Applicable 
polypeptide OTTMUSP00000034058 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010481 matrix metalloproteinase-21
References (Earliest) J:83524 Marchenko GN, et al., The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein. Biochem J. 2003 Jun 1;372(Pt 2):503-15
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(26)
Other
accession IDs
MGI:5311342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory