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Mmp21 Gene Detail
Summary
  • Symbol
    Mmp21
  • Name
    matrix metallopeptidase 21
  • Synonyms
    b2b2458Clo, b2b873Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664387
    NCBI Gene: 214766
  • Gene Overview
    MyGene.info: MMP21
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:133674270-133680061 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 77.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664387
protein coding gene Chr7:133674270-133680061 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033122
protein coding gene Chr7:138431291-138437072 (-)
A/J MGP_AJ_G0033104
protein coding gene Chr7:134594804-134600547 (-)
AKR/J MGP_AKRJ_G0033036
protein coding gene Chr7:138196646-138202427 (-)
BALB/cJ MGP_BALBcJ_G0033105
protein coding gene Chr7:134304595-134310326 (-)
C3H/HeJ MGP_C3HHeJ_G0032819
protein coding gene Chr7:138034373-138040140 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033616
protein coding gene Chr7:143684396-143690151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030587
protein coding gene Chr7:135865633-135871215 (-)
CAST/EiJ MGP_CASTEiJ_G0032149
protein coding gene Chr7:129946053-129952018 (-)
CBA/J MGP_CBAJ_G0032792
protein coding gene Chr7:148544350-148550203 (-)
DBA/2J MGP_DBA2J_G0032944
protein coding gene Chr7:132609343-132616879 (-)
FVB/NJ MGP_FVBNJ_G0032897
protein coding gene Chr7:132450968-132456753 (-)
LP/J MGP_LPJ_G0033038
protein coding gene Chr7:139947857-139954486 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032929
protein coding gene Chr7:149439489-149445260 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033636
protein coding gene Chr7:137204340-137210091 (-)
PWK/PhJ MGP_PWKPhJ_G0031855
protein coding gene Chr7:125631483-125637545 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031701
protein coding gene Chr7:123976821-123982659 (-)
WSB/EiJ MGP_WSBEiJ_G0032260
protein coding gene Chr7:138084994-138090765 (-)



Homology
more
  • Human Ortholog
    MMP21, matrix metallopeptidase 21
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MMP21, matrix metallopeptidase 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTX7, MMP-21
  • Links
    NCBI Gene ID: 118856
    neXtProt AC: NX_Q8N119
    UniProt: Q8N119

  • Chr Location
    10q26.2; chr10:125766453-125775821 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mmp21 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    30 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit heterotaxia and congenital cardiovascular defects including d-loop transposition of the great arteries, tricupid valve atresia, and ventricular septal defect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214766 NCBI Gene Model | MGI Sequence Detail 5792 C57BL/6J ±  kb
    transcript NM_152944 RefSeq | MGI Sequence Detail 1858 BALB/c  
    polypeptide Q8K3F2 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 2
      cDNA 3
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5311342, MGI:5554540
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:83524 Marchenko GN, et al., The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein. Biochem J. 2003 Jun 1;372(Pt 2):503-15
    • Latest
      J:231940 Akawi N, et al., Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Nat Genet. 2015 Nov;47(11):1363-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory