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Dsg4
Gene Detail
 Symbol
Name
ID
Dsg4
desmoglein 4
MGI:2661061
Synonyms CDHF13, lah
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:20436175-20471821 bp, + strand
From VEGA annotation of GRCm38

  35647 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Dsg4

Human
homologs
Human Homolog DSG4, desmoglein 4
NCBI Gene ID 147409
neXtProt AC  NX_Q86SJ6
Human Synonyms  CDGF13, CDHF13, HYPT6, LAH
Human Chr (Location)  18q12.1; chr18:31376777-31413917 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DSG4
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(3) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice carrying mutations at this locus exhibit abnormalities in hair growth, vibrissae growth, and a thickened epidermis.
 
Human Diseases Modeled Using Mouse Dsg4 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Dsg4 interacts with 100 markers (Mir10b, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anagen, BMP signaling pathway, ...
Component cell junction, desmosome, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (14)    Images (2)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 2
RT-PCR 13
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) Genomic(1) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000028141 (Evidence)
Ensembl Gene ModelENSMUSG00000001804 (Evidence)
Entrez Gene16769 (Evidence)
UniGene358619
DFCITC1594723
DoTSDT.101358244, DT.110770067
Consensus CDS ProjectCCDS29082.1
International Mouse Knockout Project StatusDsg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028141 VEGA Gene Model | MGI Sequence Detail 35647 C57BL/6J ±  kb
transcript OTTMUST00000069707 VEGA | MGI Sequence Detail 3478 Not Applicable 
polypeptide OTTMUSP00000035447 VEGA | MGI Sequence Detail 1041 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
InterPro IPR009123 Desmoglein
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006709 desmoglein-4
References (Earliest) J:33849 Montagutelli X, et al., Lanceolate hair (lah): a recessive mouse mutation with alopecia and abnormal hair. J Invest Dermatol. 1996 Jul;107(1):20-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16159, MGI:99398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory