Dsg4
Gene Detail

Symbol Name ID

Dsg4 desmoglein 4 MGI:2661061

Synonyms

CDHF13, lah

Feature Type

protein coding gene

Genetic Map

Chromosome 18

11.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:20436175-20471821 bp, + strand From VEGA annotation of GRCm38   35647 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:65341  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dsg4

Human homologs

Human Homolog		DSG4, desmoglein 4
NCBI Gene ID		147409
neXtProt AC		NX_Q86SJ6
Human Synonyms		CDGF13, CDHF13, LAH
Human Chr (Location)		18q12.1; chr18:28956740-28993880 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DSG4

Alleles and phenotypes

All alleles(8) : Targeted(3) Spontaneous(2) Chemically induced(3)
 

Mice carrying mutations at this locus exhibit abnormalities in hair growth, vibrissae growth, and a thickened epidermis.

 
Human Diseases Modeled Using Mouse Dsg4 (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	anagen, BMP signaling pathway, ...
Component	cell junction, desmosome, ...
Function	calcium ion binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (14)    Images (2)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	2
RT-PCR	13

External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) Genomic(1) Primer pair(1) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000028141 (Evidence)
Ensembl Gene Model	ENSMUSG00000001804 (Evidence)
Entrez Gene	16769 (Evidence)
UniGene	358619
DFCI	TC1594723
DoTS	DT.101358244, DT.110770067
Consensus CDS Project	CCDS29082.1
International Mouse Knockout Project Status	Dsg4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028141	VEGA Gene Model | MGI Sequence Detail	35647	C57BL/6J
transcript	OTTMUST00000069707	VEGA | MGI Sequence Detail	3478	Not Applicable
polypeptide	OTTMUSP00000035447	VEGA | MGI Sequence Detail	1041	Not Applicable

All sequences(22) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(108 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR015919	Cadherin-like
InterPro	IPR009123	Desmoglein
InterPro	IPR009122	Desmosomal cadherin
Protein Ontology	PR:000006709	desmoglein-4

References

(Earliest) J:33849 Montagutelli X, et al., Lanceolate hair (lah): a recessive mouse mutation with alopecia and abnormal hair. J Invest Dermatol. 1996 Jul;107(1):20-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Other accession IDs

MGD-MRK-16159, MGI:99398