Setd1a
Gene Detail

Symbol Name ID

Setd1a SET domain containing 1A MGI:2446244

Synonyms

KMT2F, MGC:55143, mKIAA0339

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:127776670-127800122 bp, + strand From VEGA annotation of GRCm38   23453 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:52251  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Setd1a

Human homologs

Human Homolog		SETD1A, SET domain containing 1A
NCBI Gene ID		9739
neXtProt AC		NX_O15047
Human Synonyms		KMT2F, Set1, Set1A
Human Chr (Location)		16p11.2; chr16:30968615-30995981 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	histone H3-K4 methylation, methylation
Component	histone methyltransferase complex, nucleus, ...
Function	histone methyltransferase activity (H3-K4 specific), methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (103)    Images (4)
Theiler Stages: 1, 2, 3, 4, 5, 22

Assay Type	Results
RNA in situ	94
RT-PCR	9

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017309 (Evidence)
Ensembl Gene Model	ENSMUSG00000042308 (Evidence)
Entrez Gene	233904 (Evidence)
DFCI	TC1580307
DoTS	DT.531195
Consensus CDS Project	CCDS40144.1
International Mouse Knockout Project Status	Setd1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017309	VEGA Gene Model | MGI Sequence Detail	23453	C57BL/6J
transcript	OTTMUST00000042031	VEGA | MGI Sequence Detail	6487	Not Applicable
polypeptide	OTTMUSP00000018899	VEGA | MGI Sequence Detail	1716	Not Applicable

All sequences(43) RefSeq(3) UniProt(7)

Polymorphisms

SNPs(66 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024657	COMPASS complex Set1 subunit, N-SET domain
InterPro	IPR015722	Histone-lysine N-methyltransferase
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR003616	Post-SET domain
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR001214	SET domain
Protein Ontology	PR:000014719	histone-lysine N-methyltransferase SETD1A

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)