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Setd1a
Gene Detail
Symbol

Name
ID
Setd1a
SET domain containing 1A
MGI:2446244
Synonyms
KMT2F, MGC:55143, mKIAA0339
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:127776670-127800122 bp, + strand
From VEGA annotation of GRCm38

  23453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52251  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SETD1A
Gene Tree: Setd1a

Human
homologs
SETD1A, SET domain containing 1A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9739
neXtProt AC: NX_O15047

Human Synonyms: KMT2F, Set1, Set1A

Human Chr (Location): 16p11.2; chr16:30948505-30984664 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Animals homozygous for this allele were dead by E7.5
 
Interactions
Setd1a interacts with 178 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (99)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 5
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase setd1a    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017309 (Evidence)
Ensembl Gene Model ENSMUSG00000042308 (Evidence)
Entrez Gene 233904 (Evidence)
DFCI TC1580307
DoTS DT.531195
EC 2.1.1.43
Consensus CDS Project CCDS40144.1
International Mouse Phenotyping Consortium Status Setd1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017309 VEGA Gene Model | MGI Sequence Detail 23453 C57BL/6J ±  kb
transcript OTTMUST00000042031 VEGA | MGI Sequence Detail 6487 Not Applicable 
polypeptide OTTMUSP00000018899 VEGA | MGI Sequence Detail 1716 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(3) UniProt(7)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024657 COMPASS complex Set1 subunit, N-SET domain
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR003616 Post-SET domain
InterPro IPR000504 RNA recognition motif domain
InterPro IPR001214 SET domain
Protein Ontology PR:000014719 histone-lysine N-methyltransferase SETD1A
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:215367 Shao GB, et al., Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory