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Setd1a Gene Detail
Summary
  • Symbol
    Setd1a
  • Name
    SET domain containing 1A
  • Synonyms
    KMT2F, MGC:55143, mKIAA0339
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446244
    NCBI Gene: 233904
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127776670-127800122 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446244
protein coding gene Chr7:127776104-127800122 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033053
protein coding gene Chr7:132149563-132173050 (+)
A/J MGP_AJ_G0033036
protein coding gene Chr7:128615883-128639402 (+)
AKR/J MGP_AKRJ_G0032968
protein coding gene Chr7:131942317-131966035 (+)
BALB/cJ MGP_BALBcJ_G0033037
protein coding gene Chr7:128270094-128293604 (+)
C3H/HeJ MGP_C3HHeJ_G0032751
protein coding gene Chr7:131844593-131868862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033546
protein coding gene Chr7:137300076-137324789 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030519
protein coding gene Chr7:129816233-129841515 (+)
CAST/EiJ MGP_CASTEiJ_G0032080
protein coding gene Chr7:123640264-123665509 (+)
CBA/J MGP_CBAJ_G0032724
protein coding gene Chr7:141949422-141972839 (+)
DBA/2J MGP_DBA2J_G0032876
protein coding gene Chr7:126596790-126621006 (+)
FVB/NJ MGP_FVBNJ_G0032829
protein coding gene Chr7:126452729-126476331 (+)
LP/J MGP_LPJ_G0032970
protein coding gene Chr7:133622353-133646651 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032861
protein coding gene Chr7:143033651-143057420 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033566
protein coding gene Chr7:130930957-130958381 (+)
PWK/PhJ MGP_PWKPhJ_G0031787
protein coding gene Chr7:119608569-119632831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031633
protein coding gene Chr7:117736949-117761604 (+)
WSB/EiJ MGP_WSBEiJ_G0032192
protein coding gene Chr7:131898485-131923262 (+)



Homology
more
  • Human Ortholog
    SETD1A, SET domain containing 1A, histone lysine methyltransferase
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SETD1A, SET domain containing 1A, histone lysine methyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KMT2F, Set1, Set1A
  • Links
    NCBI Gene ID: 9739
    neXtProt AC: NX_O15047
    UniProt: O15047

  • Chr Location
    16p11.2; chr16:30956618-30984664 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for this allele were dead by E7.5
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042308 Ensembl Gene Model | MGI Sequence Detail 23453 C57BL/6J ±  kb
    transcript ENSMUST00000047157 Ensembl | MGI Sequence Detail 5927 Not Applicable  
    polypeptide ENSMUSP00000037600 Ensembl | MGI Sequence Detail 1716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:52869 Kutsuwada K, et al., Cloning and characterization of 5'-flanking region of mouse non-selective cation channel 1. Biochim Biophys Acta. 1999 Jan 18;1444(1):92-100
    • Latest
      J:265029 Kim KY, et al., Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nat Commun. 2018 Jul 3;9(1):2583

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory