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Setd1a
Gene Detail
 Symbol
Name
ID
Setd1a
SET domain containing 1A
MGI:2446244
Synonyms KMT2F, MGC:55143, mKIAA0339
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:127776670-127800122 bp, + strand
From VEGA annotation of GRCm38

  23453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52251  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Setd1a

Human
homologs
Human Homolog SETD1A, SET domain containing 1A
NCBI Gene ID 9739
neXtProt AC  NX_O15047
Human Synonyms  KMT2F, Set1, Set1A
Human Chr (Location)  16p11.2; chr16:30957294-30984664 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for this allele were dead by E7.5
 
Interactions
Setd1a interacts with 178 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process histone H3-K4 methylation, methylation, ...
Component histone methyltransferase complex, nucleus, ...
Function histone methyltransferase activity (H3-K4 specific), methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (99)    Tissues (99)    Images (4)
Theiler Stages: 1, 2, 3, 5, 22
Assay TypeResults
RNA in situ 94
RT-PCR 5
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017309 (Evidence)
Ensembl Gene ModelENSMUSG00000042308 (Evidence)
Entrez Gene233904 (Evidence)
DFCITC1580307
DoTSDT.531195
Consensus CDS ProjectCCDS40144.1
International Mouse Knockout Project StatusSetd1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017309 VEGA Gene Model | MGI Sequence Detail 23453 C57BL/6J ±  kb
transcript OTTMUST00000042031 VEGA | MGI Sequence Detail 6487 Not Applicable 
polypeptide OTTMUSP00000018899 VEGA | MGI Sequence Detail 1716 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(3) UniProt(7)
Polymorphisms SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024657 COMPASS complex Set1 subunit, N-SET domain
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR003616 Post-SET domain
InterPro IPR000504 RNA recognition motif domain
InterPro IPR001214 SET domain
Protein Ontology PR:000014719 histone-lysine N-methyltransferase SETD1A
References (Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:208420 Bledau AS, et al., The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development. 2014 Mar;141(5):1022-35
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory