Frem2
Gene Detail

Symbol Name ID

Frem2 Fras1 related extracellular matrix protein 2 MGI:2444465

Synonyms

6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne

Feature Type

protein coding gene

Genetic Map

Chromosome 3

25.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:53513939-53657355 bp, - strand From Ensembl annotation of GRCm38   143417 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Frem2

Human homologs

Human Homolog		FREM2, FRAS1 related extracellular matrix protein 2
NCBI Gene ID		341640
neXtProt AC		NX_Q5SZK8
Human Chr (Location)		13q13.3; chr13:39261173-39461268 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FREM2

Alleles and phenotypes

All alleles(8) : Targeted(1) Gene trapped(2) Spontaneous(2) Chemically induced(2) Radiation induced(1)
 

Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Kidney development is severely affected and syndactyly is common. Phenotypes of homozygous mutants are indistinguishable from those of Fras1 homozygous mutant.

 
Human Diseases Modeled Using Mouse Frem2 (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(9)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell adhesion, cell communication, ...
Component	basement membrane, integral to membrane, ...
Function	calcium ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (203)    Tissues (53)    Images (35)
Theiler Stages: 17, 20, 21, 22, 23, 24, 26

Assay Type	Results
Immunohistochemistry	25
RNA in situ	176
RT-PCR	2

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) cDNA(55) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000037016 (Evidence)
Entrez Gene	242022 (Evidence)
UniGene	38378
DFCI	TC1582963, TC1590105, TC1659428, TC1678862
DoTS	DT.101358511, DT.97388306, DT.99853356
NIA Mouse Gene Index	U024049
Consensus CDS Project	CCDS17348.1
International Mouse Knockout Project Status	Frem2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000037016	Ensembl Gene Model | MGI Sequence Detail	143417	C57BL/6J
transcript	ENSMUST00000091137	Ensembl | MGI Sequence Detail	12347	Not Applicable
polypeptide	ENSMUSP00000088670	Ensembl | MGI Sequence Detail	3160	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1078 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR003644	Na-Ca exchanger/integrin-beta4
Protein Ontology	PR:000007657	FRAS1-related extracellular matrix protein 2

References

(Earliest) J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
(Latest) J:192553 Beck TF, et al., Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. Hum Mol Genet. 2013 Mar 1;22(5):1026-38
All references(51)

Other accession IDs

MGD-MRK-12734, MGI:1918727, MGI:3794301, MGI:5429775, MGI:97248