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Frem2 Gene Detail
Summary
  • Symbol
    Frem2
  • Name
    Fras1 related extracellular matrix protein 2
  • Synonyms
    6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444465
    NCBI Gene: 242022
  • Gene Overview
    MyGene.info: FREM2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:53513938-53657355 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 25.24 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1443 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444465
protein coding gene Chr3:53513938-53657355 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027208
protein coding gene Chr3:52113975-52264280 (-)
A/J MGP_AJ_G0027168
protein coding gene Chr3:50542889-50688822 (-)
AKR/J MGP_AKRJ_G0027137
protein coding gene Chr3:51567228-51716920 (-)
BALB/cJ MGP_BALBcJ_G0027180
protein coding gene Chr3:50409902-50553523 (-)
C3H/HeJ MGP_C3HHeJ_G0026923
protein coding gene Chr3:51795804-51946393 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027626
protein coding gene Chr3:54138565-54298022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024986
protein coding gene Chr3:47119581-47263359 (-)
CAST/EiJ MGP_CASTEiJ_G0026376
protein coding gene Chr3:51892548-52041338 (-)
CBA/J MGP_CBAJ_G0026900
protein coding gene Chr3:55848686-56018661 (-)
DBA/2J MGP_DBA2J_G0027034
protein coding gene Chr3:50125390-50269347 (-)
FVB/NJ MGP_FVBNJ_G0027002
protein coding gene Chr3:49102561-49248319 (-)
LP/J MGP_LPJ_G0027146
protein coding gene Chr3:52846250-53000245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027020
protein coding gene Chr3:59959231-60132987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027685
protein coding gene Chr3:51474864-51625895 (-)
PWK/PhJ MGP_PWKPhJ_G0026108
protein coding gene Chr3:49785435-49930625 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025921
protein coding gene Chr3:51193834-51350410 (-)
WSB/EiJ MGP_WSBEiJ_G0026450
protein coding gene Chr3:51587109-51734625 (-)



Homology
more
  • Human Ortholog
    FREM2, FRAS1 related extracellular matrix protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FREM2, FRAS1 related extracellular matrix protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRASRS2
  • Links
    NCBI Gene ID: 341640
    neXtProt AC: NX_Q5SZK8
    UniProt: Q5SZK8

  • Chr Location
    13q13.3; chr13:38687036-38887131 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18454
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FREM2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Frem2 mouse models

Human Disease Mouse Models
      
IDs
View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 7 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    16 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Kidney development is severely affected and syndactyly is common. Phenotypes of homozygous mutants are indistinguishable from those of Fras1 homozygous mutant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242022 NCBI Gene Model | MGI Sequence Detail 143418 C57BL/6J ±  kb
    transcript NM_172862 RefSeq | MGI Sequence Detail 12368 C57BL/6  
    polypeptide Q6NVD0 UniProt | EBI | MGI Sequence Detail 3160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 56
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-12734, MGI:1918727, MGI:3794301, MGI:5429775, MGI:97248
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 17
      Diseases 6
      Gene Ontology 11
      Phenotypes 35
    • Earliest
      J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
    • Latest
      J:262964 Jordan VK, et al., The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia. Hum Mol Genet. 2018 Jun 15;27(12):2064-2075

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory