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Frem2
Gene Detail
 Symbol
Name
ID
Frem2
Fras1 related extracellular matrix protein 2
MGI:2444465
Synonyms 6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne
Feature Type protein coding gene
Genetic Map
Chromosome 3
25.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:53513939-53657355 bp, - strand
From Ensembl annotation of GRCm38

  143417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Frem2

Human
homologs
Human Homolog FREM2, FRAS1 related extracellular matrix protein 2
NCBI Gene ID 341640
neXtProt AC  NX_Q5SZK8
Human Chr (Location)  13q13.3; chr13:38687036-38887131 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FREM2
Alleles
and
phenotypes
All alleles(8) : Chemically induced (ENU)(2) Gene trapped(2) Radiation induced(1) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Kidney development is severely affected and syndactyly is common. Phenotypes of homozygous mutants are indistinguishable from those of Fras1 homozygous mutant.
 
Human Diseases Modeled Using Mouse Frem2 (1)    Alleles Annotated to Human Diseases(5)    Phenotype Images(11)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, cell communication, ...
Component basement membrane, extracellular vesicular exosome, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (203)    Tissues (53)    Images (35)
Theiler Stages: 17, 20, 21, 22, 23, 24, 26
Assay TypeResults
Immunohistochemistry 25
RNA in situ 176
RT-PCR 2
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(56) cDNA(55) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000037016 (Evidence)
Entrez Gene242022 (Evidence)
UniGene38378
DFCITC1582963, TC1590105, TC1659428, TC1678862
DoTSDT.101358511, DT.97388306, DT.99853356
NIA Mouse Gene IndexU024049
Consensus CDS ProjectCCDS17348.1
International Mouse Knockout Project StatusFrem2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037016 Ensembl Gene Model | MGI Sequence Detail 143417 C57BL/6J ±  kb
transcript ENSMUST00000091137 Ensembl | MGI Sequence Detail 12347 Not Applicable 
polypeptide ENSMUSP00000088670 Ensembl | MGI Sequence Detail 3160 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(1448 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1452)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000007657 FRAS1-related extracellular matrix protein 2
References (Earliest) J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
(Latest) J:206208 Makrygiannis AK, et al., Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse. Histochem Cell Biol. 2013 Nov;140(5):595-601
All references(54)
Other
accession IDs
MGD-MRK-12734, MGI:1918727, MGI:3794301, MGI:5429775, MGI:97248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory