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Frem2
Gene Detail
Symbol

Name
ID
Frem2
Fras1 related extracellular matrix protein 2
MGI:2444465
Synonyms
6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne
Feature Type
protein coding gene
Genetic Map
Chromosome 3
25.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:53513939-53657355 bp, - strand
From Ensembl annotation of GRCm38

  143417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FREM2
Gene Tree: Frem2

Human
homologs
FREM2, FRAS1 related extracellular matrix protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 341640
neXtProt AC: NX_Q5SZK8

Human Chr (Location): 13q13.3; chr13:38687036-38887131 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FREM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(3) Gene trapped(2) Radiation induced(1) Spontaneous(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Kidney development is severely affected and syndactyly is common. Phenotypes of homozygous mutants are indistinguishable from those of Fras1 homozygous mutant.
 
Human Diseases Modeled in Mice Using Frem2 (1)    Mutations Annotated to Human Diseases (5)    Phenotype Images(16)
Interactions
Frem2 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, cell communication, ...
Component basement membrane, extracellular exosome, ...
Function calcium ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (255)    Tissues (99)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 43
RNA in situ 176
RT-PCR 36
cDNA source data(55)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN frem2a, frem2b    NEW 
Molecular
reagents
All nucleic(57) cDNA(55) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000037016 (Evidence)
Entrez Gene 242022 (Evidence)
UniGene 38378
DFCI TC1582963, TC1590105, TC1659428, TC1678862
DoTS DT.101358511, DT.97388306, DT.99853356
NIA Mouse Gene Index U024049
Consensus CDS Project CCDS17348.1
International Mouse Phenotyping Consortium Status Frem2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037016 Ensembl Gene Model | MGI Sequence Detail 143417 C57BL/6J ±  kb
transcript ENSMUST00000091137 Ensembl | MGI Sequence Detail 12347 Not Applicable 
polypeptide ENSMUSP00000088670 Ensembl | MGI Sequence Detail 3160 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(1448 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1452)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000007657 FRAS1-related extracellular matrix protein 2
References
(Earliest) J:14847 Little CC, et al., The occurrence of two heritable types of abnormality among descendants of X-rayed mice. Am J Roentgenol. 1923;10:975-989
(Latest) J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2015 Jul 30;
All references(56)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-12734, MGI:1918727, MGI:3794301, MGI:5429775, MGI:97248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory