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Gcn1l1 Gene Detail
Summary
  • Symbol
    Gcn1l1
  • Name
    GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
  • Synonyms
    G431004K08Rik, GCN1L, mKIAA0219
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444248
    NCBI Gene: 231659
  • Gene Overview
    MyGene.info: GCN1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115565254-115622654 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444248
protein coding gene Chr5:115565219-115622654 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029974
protein coding gene Chr5:118466564-118527952 (+)
A/J MGP_AJ_G0029938
protein coding gene Chr5:113743828-113801330 (+)
AKR/J MGP_AKRJ_G0029877
protein coding gene Chr5:117386980-117447332 (+)
BALB/cJ MGP_BALBcJ_G0029949
protein coding gene Chr5:115142841-115200107 (+)
C3H/HeJ MGP_C3HHeJ_G0029669
protein coding gene Chr5:117904084-117963447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030404
protein coding gene Chr5:123017935-123079632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027631
protein coding gene Chr5:108514717-108573234 (+)
CAST/EiJ MGP_CASTEiJ_G0029078
protein coding gene Chr5:116849682-116910601 (+)
CBA/J MGP_CBAJ_G0029637
protein coding gene Chr5:127750640-127809923 (+)
DBA/2J MGP_DBA2J_G0029787
protein coding gene Chr5:113829975-113887989 (+)
FVB/NJ MGP_FVBNJ_G0029743
protein coding gene Chr5:112648204-112708355 (+)
LP/J MGP_LPJ_G0029875
protein coding gene Chr5:119021644-119089897 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029774
protein coding gene Chr5:132050715-132109963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030445
protein coding gene Chr5:116864339-116924261 (+)
PWK/PhJ MGP_PWKPhJ_G0028791
protein coding gene Chr5:112476062-112536311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028629
protein coding gene Chr5:114409501-114471268 (+)
WSB/EiJ MGP_WSBEiJ_G0029153
protein coding gene Chr5:117464088-117522436 (+)



Homology
more
  • Human Ortholog
    GCN1, GCN1, eIF2 alpha kinase activator homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GCN1, GCN1, eIF2 alpha kinase activator homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCN1L, GCN1L1, PRIC295
  • Links
    NCBI Gene ID: 10985
    neXtProt AC: NX_Q92616
    UniProt: Q92616

  • Chr Location
    12q24.23; chr12:120127210-120194710 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5887
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GCN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041638 Ensembl Gene Model | MGI Sequence Detail 57401 C57BL/6J ±  kb
transcript ENSMUST00000064454 Ensembl | MGI Sequence Detail 8555 Not Applicable  
polypeptide ENSMUSP00000069432 Ensembl | MGI Sequence Detail 2671 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141013
References
more
  • Summaries
    All 40
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory